Skip to main content

Dexamethasone sodium phosphate

ADVERTISEMENT
Identification
Molecular formula
C22H28FNa2O8P
CAS number
55203-24-2
IUPAC name
disodium;[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate
State
State

At room temperature, dexamethasone sodium phosphate is typically found as a solid in pharmaceutical settings, usually prepared in the form of tablets or as a component in injectable solutions.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
539.10
Boiling point (Kelvin)
812.30
General information
Molecular weight
516.41g/mol
Molar mass
516.4140g/mol
Density
1.4660g/cm3
Appearence

Dexamethasone sodium phosphate is a white or slightly yellow crystalline powder. It is odorless and is hygroscopic, meaning it readily absorbs moisture from the environment.

Comment on solubility

Solubility of Disodium [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate

The solubility of disodium [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate can be influenced by various factors. Here are some key points to consider:

  • Solvent Polarity: Solubility is highly dependent on the polarity of the solvent. Polar solvents like water can solvate ionic compounds effectively, while non-polar solvents might not dissolve ionic entities well.
  • pH Levels: This compound may exhibit different solubility behaviors at varying pH levels due to the potential dissociation of phosphate groups.
  • Temperature Effects: Generally, increasing temperature can enhance the solubility of many solid compounds; however, it is important to confirm this experimentally for specific substances.
  • Presence of Other Ions: The solubility may also be affected by the presence of other ions in solution, which can lead to formation of more or less soluble complexes.

Considering these factors, it is essential to explore the solubility of this compound under specific conditions to understand its behavior in various environments. As with many phosphates, solubility might vary significantly and necessitate experimentation to characterize fully.

Interesting facts

Exploring Disodium [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] Phosphate

Disodium [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate is a fascinating compound with several noteworthy aspects, especially in the realm of biochemistry and pharmacology. Here are some points that highlight its significance:

  • Key Role in Biological Processes: This compound functions as a phosphate ester, which plays a critical role in various biochemical processes including energy transfer, signaling pathways, and metabolic reactions.
  • Steroidal Influence: Notably, the structure of this compound suggests it is derived from steroid-like frameworks, contributing to its potential biological activity, including hormone-like effects.
  • Research Applications: Researchers are particularly interested in this compound for its potential therapeutic applications in fields such as oncology and endocrinology.
  • Complex Structure: The intricate stereochemistry expressed in the compound's formula points to the complexity of interactions it may have within biological systems.
  • Phosphate Groups: The disodium phosphate component is crucial as phosphate groups are often involved in cellular signaling (e.g., phosphorylation), impacting protein function and enzymatic activity.

In summary, disodium [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate stands out for its sophisticated structure and essential functions in biochemistry. Its capabilities as a precursor in drug design and its potential to illuminate pathways in human health make it an exciting topic for further exploration. As with any compound of this complexity, understanding its properties continues to be a pursuit of great value within the scientific community.

Synonyms
METHYLPREDNISOLONE SODIUM PHOSPHATE
Medrol Stabisol
5015-36-1
UNII-6089CVN95V
Methylprednisolone Sodium Phosphate [USAN]
U-12,019E
6089CVN95V
EINECS 225-694-4
U-12019E
DTXSID30198222
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)
Methylprednisolone sodium phosphate (USAN)
Methylprednisolone 21-phosphate disodium salt
METHYLPREDNISOLONE SODIUM PHOSPHATE [WHO-DD]
PREGNA-1,4-DIENE-3,20-DIONE, 11,17-DIHYDROXY-6-METHYL-21-(PHOSPHONOOXY)-, DISODIUM SALT (6.ALPHA.,11.BETA.)-
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-6-methyl-21-(phosphonooxy)-, disodium salt (6alpha,11beta)-
DTXCID60120713
11.BETA.,17,21-TRIHYDROXY-6.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-(DISODIUM PHOSPHATE)
225-694-4
disodium;[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
U 12,019E
SCHEMBL1237362
CHEMBL3989785
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-6-methyl-21-(phosphonooxy)-, disodium salt, (6alpha,11beta)-
D05001
Q27263193