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Cyclophosphamide

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Identification
Molecular formula
C7H15Cl2N2O2PNa2
CAS number
6055-19-2
IUPAC name
disodium;[2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate
State
State

At room temperature, this compound is typically found in a solid form, usually as a white to off-white crystalline powder. Being a solid at room temperature, it is handled as a powder until dissolved for its end application.

Melting point (Celsius)
48.00
Melting point (Kelvin)
321.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
332.09g/mol
Molar mass
279.1220g/mol
Density
1.3000g/cm3
Appearence

Disodium phosphate-coordinated cyclophosphamide typically appears as a white to off-white solid, often provided in powder or crystalline form. It is known for being highly soluble in water, which is useful for its application in solutions for medical use.

Comment on solubility

Solubility of Disodium [2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate

The solubility of complex compounds like disodium [2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate can vary significantly based on several factors:

  • Polarity: This compound has polar phosphate groups, which generally enhance solubility in polar solvents such as water.
  • Hydrophobic Structure: The presence of chlorinated and hydrocarbon segments may lead to lower solubility in non-polar solvents.
  • pH Influence: Solubility can be affected by pH levels, as altering the pH can change the ionization of the phosphate group.
  • Temperature Dependence: Higher temperatures often increase solubility for many salts, making temperature a crucial factor.

Based on these attributes, it is often observed that:

  • This compound is expected to be more soluble in aqueous solutions due to its ionic nature.
  • However, solubility in organic solvents may be limited, often necessitating the use of co-solvents to achieve desired concentrations.

To summarize, while the disodium component may promote solubility in water, the overall structural complexity suggests a nuanced solubility profile, primarily dictated by environmental conditions and solvent choice.

Interesting facts

Interesting Facts about Disodium [2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] Phosphate

This complex compound boasts a fascinating structure and notable applications in various fields. Here are some interesting insights:

  • Pharmaceutical Relevance: Disodium phosphates are often utilized in the pharmaceutical industry, acting as key intermediates in the synthesis of biologically active compounds and drug formulations.
  • Complex Structure: The compound’s intricate arrangement highlights the synthesis challenges chemists face, particularly with the octahydrocyclopenta[a]phenanthrene core, which exhibits unique stereochemistry.
  • Biological Activity: The presence of the dichloro and hydroxy groups within its structure presents potential for significant biological action, making it an interesting subject for medicinal chemists.
  • Versatile Applications: Beyond pharmaceuticals, disodium phosphates are often employed in agricultural chemistry and biotechnology, enabling the development of innovative solutions to modern challenges.
  • Research Potential: As scientists uncover more about its properties, this compound may pave the way for advancements in drug delivery systems and targeted therapies.

In summary, disodium [2-[(9R,16R,17R)-9,11-dichloro-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] phosphate is not just a chemical entity but a gateway to a multitude of scientific endeavors. As noted by many researchers, _“the complexity of these structures often mirrors the complexity of their potential applications.”_ Discovering more about such compounds can be immensely rewarding for scientists and students alike.

Synonyms
1VYB1RE3LZ
16alpha-Methyldichlorisone phosphate disodium
16a-Methyl-dichlorisone-21-phosphate disodium
NSC-90615
UNII-1VYB1RE3LZ
14635-53-1
Pregna-1,4-diene-3,20-dione, 9,11beta-dichloro-17,21-dihydroxy-16alpha-methyl-, 21-(dihydrogen phosphate), disodium salt