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sodium cefazolin

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Identification
Molecular formula
C14H13N8Na2O4S3
CAS number
27164-46-1
IUPAC name
disodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-phenyl-2-(sulfonatoamino)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
State
State

At room temperature, sodium cefazolin is a solid. It is typically supplied as a lyophilized powder for injection.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
476.48g/mol
Molar mass
476.4810g/mol
Density
1.2800g/cm3
Appearence

Sodium cefazolin generally appears as a white to off-white crystalline powder. It may be hygroscopic and is often used as a sterile powder for injection after reconstitution.

Comment on solubility

Solubility of Disodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-phenyl-2-(sulfonatoamino)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

The solubility of disodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-phenyl-2-(sulfonatoamino)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate can be quite nuanced owing to its complex structure and multiple functional groups. Understanding its solubility is crucial for various applications, including pharmaceutical development and environmental chemistry. Here are some key points regarding its solubility:

  • Polarity: The presence of sulfonato and carboxyl functional groups typically increases polarity, suggesting enhanced solubility in polar solvents such as water.
  • Hydrogen Bonding: The compound can engage in hydrogen bonding, which can significantly influence solubility characteristics.
  • Electrolytic Behavior: As a disodium salt, it is expected to dissociate in solution, enhancing its solubility in aqueous environments.
  • Specific pH Dependence: The solubility may vary with pH due to the ionization of the carboxyl and sulfonate groups, making it more soluble under certain acidic or basic conditions.
  • Complex Formation: This compound's Solubility could be influenced by interactions with other ions in solution, forming complexes that may either enhance or reduce solubility.

In summary, the solubility of disodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-phenyl-2-(sulfonatoamino)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate is likely favorable in polar solvents, particularly water, but specific conditions and interactions will play a significant role in its actual solubility behavior.

Interesting facts

Interesting Facts about Disodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-phenyl-2-(sulfonatoamino)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

This compound is a fascinating example of a complex chemical structure that illustrates the intricate world of medicinal chemistry. Known for its unique bicyclic framework, it serves various roles in biological systems and therapeutic applications.

Key Features:

  • Structural Diversity: The compound features a bicyclic structure that includes a thia (sulfur-containing) ring, which contributes to its unique properties and biological activity.
  • Pharmacological Significance: This compound has garnered attention for its potential applications in drug development, particularly due to its ability to interact with specific biological targets.
  • Sulfonamido Group: The presence of the sulfonatoamino group greatly enhances the molecule's solubility and bioavailability, making it a focus of research in the development of pharmaceuticals.
  • Chirality: The stereochemical configuration of the compound adds another layer of complexity, indicating how subtle changes in structure can drastically affect biological activity and interaction with receptors.

This compound represents a melding of structure and function, demonstrating the principles of stereochemistry and molecular design in drug discovery. As emphasized by many chemists, "The beauty of chemistry often lies in its complexity." It serves as a reminder of the remarkable innovation happening in the field, where such intricate compounds can lead to breakthroughs in healthcare and pharmaceuticals.

Research continues to unveil the vast potential of compounds like this, highlighting the importance of understanding their unique characteristics and behaviors in biological environments. As we delve deeper into the realms of chemistry, the implications of these findings pave the way for new therapeutic strategies.