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Disodium cromoglicate

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Identification
Molecular formula
C23H14Na2O11
CAS number
15826-37-6
IUPAC name
disodium;5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate
State
State

At room temperature, disodium cromoglicate is typically in a solid state. It is usually handled as a powder, owing to its stability and form at ambient conditions.

Melting point (Celsius)
249.00
Melting point (Kelvin)
522.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
512.34g/mol
Molar mass
512.3380g/mol
Density
0.5000g/cm3
Appearence

Disodium cromoglicate appears as a white to off-white crystalline powder. It is known for its very fine consistency and is typically odorless.

Comment on solubility

Solubility Characteristics

The compound disodium 5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate, known for its complex structure, presents intriguing solubility properties. Understanding its solubility is crucial for its applications, particularly in biochemical and pharmaceutical contexts.

Key Factors Influencing Solubility:

  • Ionic Nature: As a disodium salt, the presence of sodium ions enhances solubility in polar solvents, particularly water.
  • Functional Groups: The carboxylate groups (–COO-) contribute to increased aqueous solubility due to their ability to interact with water through hydrogen bonding.
  • Structural Complexity: The chromene framework offers unique interactions that may alter solubility properties under different pH conditions.
  • Temperature Effects: Solubility can be temperature dependent, with increased temperatures generally promoting greater dissolution of the compound.

In summary, this compound is likely to be soluble in water due to its ionic interactions and polar functional groups, but careful consideration of pH and temperature is necessary to fully understand its solubility behavior. The complexity of its structure also suggests that solubility may vary across different solvents and concentrations.

Interesting facts

Interesting Facts about Disodium 5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate

Disodium 5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate is a fascinating compound in the world of organic chemistry, particularly due to its unique structural features and potential applications. Here are some intriguing aspects of this compound:

  • Chemical Structure: This compound is characterized by its chromene backbone, which is known for its role in numerous biological activities. The presence of different functional groups, such as carboxylates and hydroxy groups, enhances its versatility.
  • Biological Activity: Compounds with chromene derivatives are often studied for their pharmacological properties. They are associated with activities such as anti-inflammatory, antioxidant, and antitumor effects, making them of great interest in medicinal chemistry.
  • Solubility Potential: The incorporation of disodium ions suggests improved solubility in aqueous solutions, which can facilitate the compound's bioavailability and efficacy in biological systems.
  • Research Applications: The synthesis of such complex compounds can lead to advancements in chemical research, particularly in the development of new therapeutic agents. The intricate nature of its structure allows scientists to explore modification for tailored applications.
  • Environmentally Friendly Features: The use of carboxylate ions indicates a potentially lower environmental impact, as carboxylate groups can enhance biodegradability compared to more persistent groups.

In summary, disodium 5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate stands out for its unique chemical architecture and potential therapeutic applications. As stated by noted chemist John M. C. Hodge: "The beauty of nature's chemistry lies in the complexity and potential of every molecule." Each study of such compounds can pave the way for groundbreaking discoveries in drug design and environmental chemistry.

Synonyms
CROMOLYN SODIUM
15826-37-6
Sodium cromoglycate
Disodium cromoglycate
sodium cromoglicate
Sodium cromolyn
Gastrocrom
Cromolyn disodium salt
Cromoptic
Crolom
Cromoglycate disodium
Natrii cromoglicas
Natrium cromoglicat
Cromoglicate Sodium
Lomusol
Rynacrom
Astilyn
Disodium cromolyn
FPL 670
DSCG
FPL.670
CHEBI:128458
Q2WXR1I0PK
FPL670
DTXSID7044554
NSC-109500
Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan
Disodium 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylate)
4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt)
DTXCID5024554
Acid, Cromoglicic
Acid, Cromoglycic
Cromoglycate, Sodium
NSC109500
Cromoglycate, Disodium
Clariteyes
Aerocrom
Allercrom
Catacrom
Cromogen
Cromolux
Cromosol
Cusilyn
Glycavent
Vivicrom
Vividrin
Aspire
Murine
Cromosol optha
Opticrom aq
Resiston one
Rynacrom co
Rynacrom allergy
Brol-eze
Eye-crom
Hay-crom
Viz-on
Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-carboxylate]
Cromogen e-breathe
Steri-neb cromogen
Gppe syncroner inha
Intal 5
Resiston treatment pack
Dominion pharma hayfever
Cromolyn Sodium Inhalation
Cromolyn Sodium Inhalation Solution
Cromolyn Sodium Oral Solution (Concentrate)
Disodium 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylate)
239-926-7
5,5'-((2-Hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylic Acid), Disodium Salt
Cromolyn sodium salt
Nasalcrom
Opticrom
Intal
Chromolyn sodium
cromolyn disodium
Cromolyn (sodium)
Aararre
FPL-670
Frenasma
Lomudas
Nebulasma
Nasmil
Cromolyn disodium salt hydrate
Cromo asma aerosol
Dinatrium cromoglicicum
MFCD00057744
Cromoglicic acid;Duracroman
4H-1-Benzopyran-2-carboxylicacid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, sodium salt (1:2)
Disodium Cromoglycate;FPL-670
Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate)
Gastrofrenal
Lomuda
Intal nebulizer
CAS-15826-37-6
sodium 5,5'-((2-hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylate)
C23H14Na2O11
Cromolyn sodium [USAN]
Inostral (Anti-asthmatic)
Natrium cromoglicat [German]
CCRIS 3194
NCGC00021142-02
EINECS 239-926-7
UNII-Q2WXR1I0PK
Sodium cromoglicate [JAN]
NSC 109500
Cromolyn sodium [USAN:USP]
Cromlyn Sodio
Cromoglicinsaeure, dinatriumsalz
Cromolina Sodica
Cromolyn Na
Cromolyne sodique
Cromoglycinic acid
Gastrocrom (TN)
Prestwick_996
cromoglicato de sodio
Intal (TN)
Cromolyn sodium (USP)
CHEMBL74
Epitope ID:122681
Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [German]
SCHEMBL7500
5,5'-((2-Hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylic acid) disodium salt
Cromoglycate,Cromoglycic acid
Sodium cromoglicate (JP18)
disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
SPECTRUM1500210
orb1309197
CROMOLYN SODIUM [VANDF]
SCHEMBL29381782
SCHEMBL29382339
HMS502K19
CROMOLYN SODIUM [USP-RS]
VLARUOGDXDTHEH-UHFFFAOYSA-L
HMS1570D05
HMS1920A18
HMS2089N09
HMS2091I06
HMS2097D05
HMS3714D05
BCP12933
CROMOLYN DISODIUM SALT [MI]
SODIUM CROMOGLICATE [MART.]
Tox21_110863
Tox21_302003
CCG-40261
CROMOGLICATE SODIUM [WHO-DD]
s1911
SODIUM CROMOGLICATE [WHO-IP]
CROMOLYN SODIUM [ORANGE BOOK]
AKOS015895760
AKOS015913923
AKOS016339565
Tox21_110863_1
CROMOLYN SODIUM [USP MONOGRAPH]
FC20587
KS-5299
NCGC00017083-01
NCGC00017083-02
NCGC00017083-03
NCGC00022858-08
NCGC00094633-01
NCGC00094633-02
NCGC00255950-01
4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, disodium salt
AC-18734
NATRII CROMOGLICAS [WHO-IP LATIN]
SODIUM CROMOGLICATE [EP MONOGRAPH]
C2521
NS00078183
ST50999688
A10703
D00526
Q10261779
disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate)
sodium 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylate)
4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt
5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylic Acid) Disodium Salt
5-[3-(2-carboxy-4-oxochromen-5-yloxy)-2-hydroxypropoxy]-4-oxochromene-2-carbox ylic acid, sodium salt, sodium salt
Cromolyn sodium;Sodium cromoglycate 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium; DSCG
disodium 5-[3-(2-carboxylato-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylate
disodium 5-{3-[(2-carboxylato-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylate
disodium;5-[3-(2-carboxylato-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylate
Sodium salt of 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid