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Thienamycin

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Identification
Molecular formula
C11H12N2Na2O5S2
CAS number
59976-61-1
IUPAC name
disodium;6-[[2-carboxylato-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
State
State

At room temperature, Thienamycin is typically in a solid state, often distributed as a dry powder for laboratory or clinical use.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.20
Boiling point (Celsius)
496.10
Boiling point (Kelvin)
769.30
General information
Molecular weight
368.33g/mol
Molar mass
349.3900g/mol
Density
1.4400g/cm3
Appearence

Thienamycin typically appears as a white to off-white crystalline powder. It is commonly used in the form of its sodium salt derivatives for increased stability and solubility.

Comment on solubility

Solubility of Disodium 6-[[2-carboxylato-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

The solubility of the compound disodium 6-[[2-carboxylato-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate can be influenced by several factors:

  • Polarity: Given its multiple carboxylate groups, this compound exhibits polar characteristics, often leading to increased solubility in polar solvents such as water.
  • pH Levels: The solubility may vary significantly at different pH levels, as the ionization state of carboxylate groups can change.
  • Temperature: Like many organic compounds, solubility typically increases with temperature. Therefore, higher temperatures may enhance the solubility of this compound.

While this compound may demonstrate good solubility in aqueous environments, its specific solubility profile would require empirical testing to confirm quantitative values in various solvents.

In summary, the solubility of this compound is largely attributed to its polar functional groups and can be optimized by adjusting conditions such as pH and temperature.

Interesting facts

Interesting Facts about Disodium 6-[[2-carboxylato-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

This compound, known as disodium 6-[[2-carboxylato-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, is quite fascinating for several reasons:

  • Biological Significance: This compound exhibits properties that make it significant in the field of medicinal chemistry. Its structure suggests potential uses in drug formulation due to its unique bicyclic framework and functional groups.
  • Synthetic Relevance: The presence of thiene rings highlights its synthetic utility. Thienyl groups are often incorporated into organic molecules to enhance bioactivity and solubility.
  • Enzyme Interaction: Compounds with such structural complexity can play a role in enzyme inhibition or activation, potentially providing pathways for novel therapeutic agents.
  • Structure-Activity Relationships: The unique combination of thienyl and carboxylate groups may offer valuable insights when studying the structure-activity relationships (SAR) of similar compounds.

Furthermore, its intricate bicyclic structure, which includes a thia and azabicyclo unit, prompts exploration into its reactivity and stability under various conditions. The potential this compound holds for various pharmacological applications makes it an exciting subject of study in modern chemistry.

As a compound that bridges the gap between organic chemistry and medicinal applications, it illustrates the beauty of chemical diversity and the importance of understanding molecular interactions. With ongoing research in this area, scientists continue to uncover new uses and characteristics of such compounds that could one day lead to breakthrough therapies.

Synonyms
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[(2R)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-, disodiumsalt, (2S,5R,6R)-
disodium;6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
SCHEMBL4935403
disodium;(2S,5R,6R)-6-[(2-carboxylato-2-thiophen-3-ylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
AKOS025402077
AC-4338
PD055349
DB-070767
(2S,5R,6R)-6-[[(2R)-2-Carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
disodium 6-[2-carboxylato-2-(thiophen-3-yl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Sodium (2S,5R,6R)-6-(2-carboxylato-2-(thiophen-3-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate