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Clemastine Fumarate

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Identification
Molecular formula
C21H26ClNO3
CAS number
15686-51-8
IUPAC name
ethyl 1-[2-(2-hydroxy-2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)ethyl]-4-phenyl-piperidin-1-ium-4-carboxylate;chloride
State
State

At room temperature, Clemastine fumarate is a solid. It appears as a crystalline powder and is typically stored in a dry place to prevent moisture absorption.

Melting point (Celsius)
222.50
Melting point (Kelvin)
495.65
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
510.07g/mol
Molar mass
510.0720g/mol
Density
1.1225g/cm3
Appearence

Clemastine fumarate is a white to off-white crystalline powder. It is odorless and has a bitter taste. The compound is typically used in its fumarate salt form to enhance its solubility in water. Clemastine fumarate is often administered in tablet or liquid form for medical uses.

Comment on solubility

Solubility of Ethyl 1-[2-(2-hydroxy-2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)ethyl]-4-phenyl-piperidin-1-ium-4-carboxylate;chloride

The solubility of this compound is influenced by several factors, primarily due to its complex structure. Here are key aspects to consider:

  • Polarity: The presence of the ionic piperidinium group contributes to the overall polarity of the molecule, potentially enhancing its solubility in polar solvents, such as water.
  • Hydrogen Bonding: The hydroxyl group in the structure may facilitate hydrogen bonding, further improving its solubility in aqueous environments.
  • Organic Solvents: Conversely, the aromatic phenyl and tricyclic structures can increase solubility in nonpolar organic solvents, such as chloroform or ether, due to the hydrophobic interactions.
  • Temperature Effects: Like many compounds, solubility is likely to increase with temperature, making it essential to consider environmental conditions when evaluating solubility.

In summary, this compound demonstrates varying solubility characteristics based on its unique structural features, making it soluble in both polar and nonpolar solvents to varying extents. Understanding these solubility properties is crucial for applications in chemical synthesis and formulation.

Interesting facts

Interesting Facts about Ethyl 1-[2-(2-hydroxy-2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)ethyl]-4-phenyl-piperidin-1-ium-4-carboxylate; Chloride

This compound, a complex quaternary ammonium salt, exhibits intriguing structural features and potential applications that pique the interest of researchers in various fields. Here are some fascinating aspects to consider:

  • Structural Diversity: The presence of a tricyclic structure contributes to the compound's unique three-dimensional conformation. This diversity in structure often leads to varying biological activities.
  • Pharmacological Potential: Compounds like this are often studied for their potential therapeutic effects. The combination of a piperidine ring with phenyl groups is a characteristic feature of many biologically active molecules, including pharmaceuticals.
  • Ionization and Solubility: As a quaternary ammonium compound, it is likely to have interesting solubility characteristics that may affect its interaction with biological systems. The charged nature of the molecule can significantly influence its absorption and distribution in living organisms.
  • Source of Inspiration: According to the renowned chemist Linus Pauling, “Chemistry is the science of substances, their structure, properties, and reactions.” This compound embodies the essence of chemistry by demonstrating how intricate structures can lead to diverse properties and reactions.
  • Research Opportunities: The complexity of this compound presents various research avenues in organic synthesis, drug development, and material science, contributing to the ongoing exploration of chemical compounds in modern science.

In conclusion, the compound ethyl 1-[2-(2-hydroxy-2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)ethyl]-4-phenyl-piperidin-1-ium-4-carboxylate; chloride exemplifies how intricate chemistry can lead to exciting possibilities in science and industry.

Synonyms
15991-27-2
Isonipecotic acid, 1-(2-(10,11-dihydro-5-hydroxy-5H-dibenzo(a,d)cyclohepten-5-yl)ethyl)-4-phenyl-, ethyl ester, hydrochloride