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Loratadine

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Identification
Molecular formula
C22H23ClN2O2
CAS number
79794-75-5
IUPAC name
ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate
State
State

At room temperature, loratadine is typically in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
443.80
Boiling point (Kelvin)
716.95
General information
Molecular weight
382.89g/mol
Molar mass
382.4660g/mol
Density
1.1200g/cm3
Appearence

Loratadine is a white to off-white crystalline powder. It is practically insoluble in water, but freely soluble in ethanol, methanol, and acetone.

Comment on solubility

Solubility of Ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate

The solubility of ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate can be influenced by various factors due to its complex structure. Understanding its solubility characteristics is crucial in various applications, especially in pharmaceutical formulations. Here are some key points to consider:

  • Polar vs Non-Polar Solvents: This compound may exhibit differing solubility in polar and non-polar solvents due to the presence of both hydrophobic and hydrophilic regions in its structure.
  • Temperature Dependence: Like many organic compounds, its solubility can increase with temperature, making heat an important factor in dissolution.
  • pH Levels: As a piperidine derivative, it may also show changes in solubility with varying pH levels, which could affect its ionization state.
  • Hydrogen Bonding: The presence of nitrogen atoms may allow for hydrogen bonding with solvent molecules, enhancing its solubility in certain environments.

In summary, while ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate may have limited solubility in pure water, it could be more soluble in organic solvents like ethanol or DMSO. Its complex molecular structure provides a fascinating challenge in predicting and optimizing its solubility for various applications.

Interesting facts

Interesting Facts about Ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate

This intriguing compound is an example of a complex organic molecule that showcases the fascinating interplay between chemical structure and biological activity. Here are some captivating insights:

  • Pharmaceutical Significance: Compounds like this one are often studied for their potential therapeutic applications, particularly in the realm of neuroscience and psychopharmacology. They may interact with various neurotransmitter systems, which can lead to significant implications in treating disorders such as depression and anxiety.
  • Structural Diversity: The structure of this compound features a unique arrangement of piperidine and piperazine rings, which are known for their role in increasing the lipophilicity of drugs. The incorporation of methyl and phenyl groups can enhance binding affinity to receptors, improving the overall efficacy of the compound.
  • Mechanism of Action: Although specific details about the mechanism of action are often complex and require extensive research, molecules with similar architectures are frequently studied for their ability to modulate neurotransmitter levels, leading to diverse pharmacological effects.
  • Synthetic Pathways: The preparation of such multi-substituted compounds demands meticulous synthetic strategies. Researchers often utilize multi-step synthesis techniques, which involve intricate reactions and purification processes to yield high-purity products.
  • Research Potential: Ongoing studies aim to uncover the full spectrum of biological activities associated with this compound. As noted by chemists, “The modification of substituents can lead to a plethora of derivatives with varying pharmacological profiles.” This highlights the importance of structural variations in drug discovery.

In summary, ethyl 1-[2-(4-methylpiperazin-1-yl)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate stands as a prime example of how intricate chemical design can pave the way for groundbreaking research and potential therapeutic advancements.

Synonyms
AKOS005065562