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Ketamine

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Identification
Molecular formula
C15H24ClNO2
CAS number
6740-88-1
IUPAC name
ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate
State
State

At room temperature, ketamine is generally encountered as a solid in its hydrochloride salt form. When distributed for intravenous applications or other uses, it may be dissolved in water or saline, appearing as a clear liquid.

Melting point (Celsius)
94.00
Melting point (Kelvin)
367.00
Boiling point (Celsius)
411.00
Boiling point (Kelvin)
684.00
General information
Molecular weight
323.45g/mol
Molar mass
323.4520g/mol
Density
1.0450g/cm3
Appearence

Ketamine is typically a white crystalline powder or a colorless, slightly viscous liquid. In its powdered form, it is often used in medical settings or as an illicit drug. It may appear in various colors when in solution, depending on the preparation and intended use.

Comment on solubility

Solubility of Ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate

The solubility of ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate in various solvents can be a critical factor influencing its applications in chemical synthesis and pharmaceuticals. Generally, the solubility of this compound can be evaluated based on the following considerations:

  • Nonpolar Solvents: The aromatic and aliphatic components of the molecule suggest increased solubility in nonpolar solvents such as hexane and benzene.
  • Polar Solvents: Limited solubility may occur in polar solvents like water due to the overall hydrophobic character; however, some solubility can be anticipated if any polar functional groups are present.
  • Temperature Dependency: Solubility often increases with temperature. Hence, assessing the solubility at higher temperatures could yield more favorable results for potential applications.
  • pH Influence: The solubility may also be affected by the pH of the solution, especially if the diethylamino group can become protonated, altering its interaction with solvents.

In summary, while the solubility of ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate in water is expected to be quite low, an increase in solubility is likely with nonpolar organic solvents and under elevated temperatures. Understanding the solubility profile is essential for optimizing its usage in various chemical processes.

Interesting facts

Interesting Facts about Ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate

The compound known as ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate is a fascinating example of a piperidine derivative, which belongs to a class of compounds that are often studied for their potential medicinal properties. Here are some interesting aspects of this compound:

  • Structure and Activity: The complexity of its structure, featuring a piperidine ring and multiple substituents, contributes to its unique chemical behavior and biological activity. This compound is often investigated for its potential in various pharmacological applications.
  • Pharmacological Potential: Due to its structural components, it has been suggested that ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate may exhibit interesting interactions with neurotransmitter systems. This has led to explorations into its efficacy as a potential drug for conditions such as pain, anxiety, or mood disorders.
  • Synthesis Challenges: The synthesis of such complex molecules is often challenging and requires advanced synthetic techniques. Chemists may employ various strategies such as multi-step synthesis, regioselective reactions, and protection-deprotection steps to achieve the desired product.
  • Role in Research: Compounds like this serve as important tools in biochemical research, allowing scientists to better understand receptor binding mechanisms and the pharmacokinetics of drug delivery systems.
  • Future Directions: Continued research may unveil more about the compound’s therapeutic potential, and ongoing investigations could refine its efficacy and safety profile for clinical use.

In conclusion, ethyl 1-[2-(diethylamino)-2-phenyl-ethyl]-4-phenyl-piperidine-4-carboxylate represents a rich area of study in both organic chemistry and pharmacology. As researchers delve deeper into its characteristics, the potential applications of this compound might expand significantly.