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Cefuroxime axetil

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Identification
Molecular formula
C20H22N4O10S
CAS number
64544-07-6
IUPAC name
ethyl 1-[[2-methyl-1,1-dioxo-3-(2-pyridylcarbamoyl)-1lambda6,2-benzothiazin-4-yl]oxy]ethyl carbonate
State
State

At room temperature, cefuroxime axetil is a solid. The compound is typically handled as a powder in pharmaceutical preparations. It is stable under normal conditions of use and storage.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
512.55g/mol
Molar mass
512.5510g/mol
Density
1.4500g/cm3
Appearence

Cefuroxime axetil is typically seen as a white to off-white crystalline powder. It may be odorless or have a faint characteristic odor. Its appearance can vary slightly based on the physical form (e.g., crystalline or powder) in which it is presented.

Comment on solubility

Solubility of Ethyl 1-[[2-methyl-1,1-dioxo-3-(2-pyridylcarbamoyl)-1lambda6,2-benzothiazin-4-yl]oxy]ethyl Carbonate

The solubility of the compound ethyl 1-[[2-methyl-1,1-dioxo-3-(2-pyridylcarbamoyl)-1lambda6,2-benzothiazin-4-yl]oxy]ethyl carbonate (C20H22N4O10S) can be quite intriguing due to its complex structure. This compound features multiple functional groups that can influence its solubility in different solvents:

  • Polarity: The presence of polar functional groups, such as the carbamoyl and carbonate moieties, suggests that the compound may exhibit moderate to high solubility in polar solvents like water and methanol.
  • Hydrophobic interactions: The benzothiazine component could impart a degree of hydrophobicity, which may lead to decreased solubility in strictly polar environments.
  • pH-dependent solubility: Solubility may also vary significantly with pH changes due to the potential protonation of nitrogen atoms in the pyridyl group, affecting its overall solubility profile.
  • The role of temperature: As with many organic compounds, solubility may increase with temperature, allowing for better incorporation into various solvents at elevated temperatures.

In summary, the solubility of this compound is likely to be influenced by a variety of factors, including its functional groups and the characteristics of the solvent. Understanding these aspects is essential for effectively utilizing this compound in applications and further research.

Interesting facts

Interesting Facts about Ethyl 1-[[2-Methyl-1,1-Dioxo-3-(2-Pyridylcarbamoyl)-1λ6,2-Benzothiazin-4-yl]Oxy]Ethyl Carbonate

This fascinating compound, ethyl 1-[[2-methyl-1,1-dioxo-3-(2-pyridylcarbamoyl)-1λ6,2-benzothiazin-4-yl]oxy]ethyl carbonate, belongs to a class of compounds known for their diverse applications in medicinal chemistry and bioactivity. Here are some intriguing points to consider:

  • Active Champions: The presence of the pyridyl group suggests potential activity against various biological targets, making it a candidate for drug development.
  • Structural Complexity: The incorporation of dioxo and benzothiazin moieties illustrates the intricate nature of its structure, which often correlates with unique chemical properties.
  • Pharmaceutical Potential: Compounds with similar scaffolds are often evaluated for their effectiveness as anti-cancer agents and antibacterial drugs.
  • Connecting Carbonates: The ethyl carbonate moiety not only enhances solubility and stability but may also influence the compound's pharmacokinetics, which is the study of how a substance is absorbed, distributed, metabolized, and excreted in the body.
  • In-depth Research: Studies have shown that derivatives of benzothiazine can exhibit remarkable activities, prompting ongoing scientific research to unlock their full potential.

A quote from renowned chemist Marie Curie resonates here: “Nothing in life is to be feared, it is only to be understood.” Engaging in the study of complex compounds like this one fuels our understanding of chemistry and its potential to revolutionize medicine.

In essence, the ethyl 1-[[2-methyl-1,1-dioxo-3-(2-pyridylcarbamoyl)-1λ6,2-benzothiazin-4-yl]oxy]ethyl carbonate exemplifies the beauty of synthetic chemistry, where intricate molecular designs can lead to groundbreaking discoveries in the pharmaceutical realm.

Synonyms
ampiroxicam
99464-64-9
Flucam
CP 65703
Ampiroxicamum
CP-65703
Ampiroxicamum [Latin]
0PV32JZB1J
Ampiroxicam [INN:BAN:JAN]
NSC-759807
Flucam (TN)
BRN 5184713
DTXSID6046474
CHEBI:31210
AMPIROXICAM [MI]
AMPIROXICAM [INN]
AMPIROXICAM [JAN]
ethyl 1-{[2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2h-1,2-benzothiazin-4-yl]oxy}ethyl carbonate
AMPIROXICAM [MART.]
AMPIROXICAM [WHO-DD]
CP-65,703
Carbonic acid, ethyl 1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl ester, S,S-dioxide
DTXCID4026474
NSC 759807
Ampiroxicamum (Latin)
NCGC00164605-01
AMPIROXICAM (MART.)
(+-)-4-(1-Hydroxyethoxy)-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide ethyl carbonate (ester), 1,1-dioxide
ethyl (1-((2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-benzo[e][1,2]thiazin-4-yl)oxy)ethyl) carbonate
Nacyl
(+/-)-4-(1-HYDROXYETHOXY)-2-METHYL-N-2-PYRIDYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE ETHYL CARBONATE (ESTER), 1,1-DIOXIDE
carbonic acid ethyl 1-({2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl}oxy)ethyl ester S,S-dioxide
CAS-99464-64-9
UNII-0PV32JZB1J
carbonic acid ethyl 1-((2-methyl-3-((2-pyridinylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl ester S,S-dioxide
Carbonic acid ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester;CP 65703;Flucam
Ethyl (1RS)-1-((2-methyl-1,1-dioxido-3-((pyridin-2-ylamino)carbonyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl carbonate
Ethyl (1RS)-1-({2-methyl-1,1-dioxido-3-[(pyridin-2-ylamino)carbonyl]-2H-1,2-benzothiazin-4-yl}oxy)ethyl carbonate
ethyl 1-((2-methyl-1,1-dioxido-3-(pyridin-2-ylcarbamoyl)-2H-1,2-benzothiazin-4-yl)oxy)ethyl carbonate
Ampiroxicam (Standard)
Ampiroxicam (JP18/INN)
SCHEMBL49363
MLS001424306
Ampiroxicam - Bio-X trade mark
CHEMBL1566249
SCHEMBL21357883
Ampiroxicam, >=98% (HPLC)
HMS2052J03
HMS2090I13
HMS2232L11
HMS3372K07
HMS3394J03
HMS3652M15
HMS3715N12
HMS3885A18
Pharmakon1600-01504830
BCP13545
Tox21_112227
HY-17484R
NSC759807
s4011
AKOS015900478
Tox21_112227_1
CCG-101155
CCG-213956
FA17891
NC00405
NCGC00164605-02
AC-18891
AC-32693
AS-56304
BA164172
ethyl 1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1lambda6,2-benzothiazin-4-yl]oxy]ethyl carbonate
HY-17484
SMR000469285
DB-057785
NS00123293
SW219542-1
C77384
D01397
AB00698363-05
AB00698363_06
AB00698363_07
SR-01000763537
Q3614672
SR-01000763537-3
BRD-A39172021-001-06-1
BRD-A39172021-001-09-5
BRD-A39172021-001-10-3
BRD-A39172021-001-11-1
BRD-A39172021-001-13-7
methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylate
807-877-6
ETHYL 1-([2-METHYL-1,1-DIOXIDO-3-[(2-PYRIDINYLAMINO)CARBONYL]-2H-1,2-BENZOTHIAZIN-4-YL]OXY)ETHYL CARBONATE
ethyl 1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1$l^{6,2-benzothiazin-4-yl]oxy]ethyl carbonate