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Fentanyl

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Identification
Molecular formula
C28H36N2O5
CAS number
437-38-7
IUPAC name
ethyl 1-(2-morpholino-2-phenyl-ethyl)-4-phenyl-piperidin-1-ium-4-carboxylate;4-hydroxy-4-oxo-but-2-enoate
State
State

At room temperature, fentanyl is a solid. It displays a crystalline powder form and is highly potent even in small quantities. It needs to be handled under controlled conditions to prevent accidental exposure.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.15
General information
Molecular weight
528.63g/mol
Molar mass
528.6320g/mol
Density
1.2300g/cm3
Appearence

Ethyl 1-(2-morpholino-2-phenyl-ethyl)-4-phenyl-piperidin-1-ium-4-carboxylate;4-hydroxy-4-oxo-but-2-enoate is typically found as a white to off-white solid powder. It is known for its high potency and is highly soluble in organic solvents.

Comment on solubility

Solubility of Ethyl 1-(2-morpholino-2-phenyl-ethyl)-4-phenyl-piperidin-1-ium-4-carboxylate; 4-hydroxy-4-oxo-but-2-enoate

The solubility of this complex compound can be influenced by a variety of factors due to its intricate structure. Generally, compounds with a polar character tend to have better solubility in polar solvents like water, whereas nonpolar compounds are more soluble in nonpolar solvents such as organic solvents. For this particular compound, several aspects come into play:

  • Ionization State: The presence of the piperidin-ium moiety suggests that this compound may exist in a charged state, which typically enhances solubility in water.
  • Hydrophilic Groups: The carboxylate group can interact favorably with water molecules, making hydration more feasible.
  • Hydrophobic Groups: The inclusion of phenyl and morpholino groups might introduce hydrophobic interactions that could decrease solubility in polar solvents.

Overall, one might expect that while some components promote solubility in aqueous solutions, others may potentially limit it due to their hydrophobic character. Therefore, the solubility of this compound could best be described as moderate in water, but it may exhibit enhanced solubility in organic solvents like ethanol or DMSO.

In conclusion, the solubility characteristics of ethyl 1-(2-morpholino-2-phenyl-ethyl)-4-phenyl-piperidin-1-ium-4-carboxylate; 4-hydroxy-4-oxo-but-2-enoate depend upon a delicate balance of the polarity and hydrophobic interactions, making it a subject of interest for further solubility studies.

Interesting facts

Exploring Ethyl 1-(2-Morpholino-2-phenyl-ethyl)-4-phenyl-piperidin-1-ium-4-carboxylate; 4-Hydroxy-4-Oxo-But-2-Enoate

This interesting compound, known for its complex structure and diverse functionalities, falls into the realm of medicinal chemistry. Here are some engaging insights that highlight its intriguing characteristics:

  • Pharmaceutical Potential: This compound contains a piperidine ring, which is a common motif in numerous pharmaceuticals. It has been associated with activities such as analgesia and anti-inflammatory responses.
  • Morpholino Group: The presence of a morpholino moiety suggests potential applications in drug design, particularly in enhancing bioavailability and modulating receptor interactions.
  • Diverse Reactivity: The carboxylate functionality is known for its involvement in numerous chemical transformations. This can open up pathways for synthesizing various derivatives or conjugates with improved properties.
  • Influence of Aromatic Systems: The dual presence of phenyl groups contributes to the electronic properties of the compound. These aromatic systems can participate in stacking interactions with biological macromolecules, influencing the binding affinity and overall activity.

Many scientists are drawn to compounds such as this due to their rich potential for investigation. As research continues, the exploration of its mechanisms and interactions could yield valuable insights in the fields of pharmacology and organic synthesis.

As noted by one researcher, "It is the intricate dance of these functional groups that may lead us to the next breakthrough in therapeutic development."