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Cidofovir

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Identification
Molecular formula
C8H14N3O2P
CAS number
113852-37-2
IUPAC name
ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate
State
State

Solid at room temperature.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.20
Boiling point (Celsius)
187.50
Boiling point (Kelvin)
460.60
General information
Molecular weight
501.50g/mol
Molar mass
279.2130g/mol
Density
1.1807g/cm3
Appearence

Cidofovir is a white crystalline powder. It is typically odorless.

Comment on solubility

Solubility of Ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate

The solubility of the compound ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate is influenced by several factors, primarily due to its molecular structure which includes both hydrophobic and hydrophilic regions. Understanding its solubility can be approached by considering the following key points:

  • Polarity: The presence of the carboxylate group may contribute to some polar characteristics, enhancing solubility in polar solvents, but the bulky diphenyl and phenyl groups dominate, likely leading to lower solubility in water.
  • Solvent Compatibility: It is expected to exhibit better solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and chloroform, where the hydrophobic regions can more easily interact with the solvent molecules.
  • Crystallization: The low solubility could also imply challenges in crystallization for purification purposes; potential methods may include gradient evaporation or the use of co-solvents.

As a general guideline, “like dissolves like” applies here. Hence, for practical applications, ensuring the use of compatible solvents is crucial for effective dissolution of this compound. Before experimental work, conducting preliminary solubility tests in various solvents would be advisable to optimize conditions for reactions or formulations involving this compound.

Interesting facts

Interesting Facts about Ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate

Ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate is a fascinating compound that belongs to the class of piperidine derivatives. These derivatives are often studied for their unique properties and potential applications in various fields.

Chemical Structure and Functionality

This compound features an intricate structure that contributes to its biological activity and versatility. Several interesting aspects include:

  • Piperidine Ring: The piperidine ring is known for its robustness in organic synthesis and is frequently encountered in pharmaceutical compounds.
  • Diphenyl Group: The presence of a diphenyl group can enhance the compound's stability and influence its interaction with biological targets.
  • Keto Functionality: The 2-oxo group adds to the reactivity of the compound, making it a candidate for forming various derivatives in chemical reactions.

Biological Importance

Compounds similar to ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate are often studied for their potential pharmacological applications. Some notable points include:

  • Psychoactive Properties: Piperidine derivatives are associated with various activities, including analgesic effects and potential use in treating neurological disorders.
  • Research Interest: The compound may serve as a lead structure for the synthesis of new therapeutic agents targeting specific diseases.

Synthesis and Applications

The synthesis of this compound is of particular interest to organic chemists, as it involves:

  • Multi-step Reactions: The synthesis requires careful manipulation of various functional groups, showcasing classic organic synthesis techniques.
  • Potential Uses: Its variations can be utilized in medicinal chemistry, particularly in drug development.

In conclusion, ethyl 1-(2-oxo-3,3-diphenyl-propyl)-4-phenyl-piperidine-4-carboxylate is a compound rich in structural complexity and potential applications, making it a noteworthy subject of study in the field of chemistry.