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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
ethyl 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-phenyl-piperidine-4-carboxylate
State
State

At room temperature, Loperamide is in a solid state. It is stable under ordinary conditions and does not volatilize easily.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
457.40
Boiling point (Kelvin)
730.55
General information
Molecular weight
477.59g/mol
Molar mass
477.5850g/mol
Density
1.2200g/cm3
Appearence

Loperamide is typically a white or slightly off-white powder. It is crystalline in nature and its solid form is not colored, allowing it to appear white under normal circumstances. The texture is consistent with other crystalline powders, and it may exhibit a mild, characteristic odor.

Comment on solubility

Solubility of Ethyl 1-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl]-4-phenyl-piperidine-4-carboxylate

The solubility of the compound ethyl 1-[3-(5,6-dihydrobenzob[1]benzazepin-11-yl)propyl]-4-phenyl-piperidine-4-carboxylate can be described as follows:

  • Solvent Compatibility: This compound is expected to show varying solubility depending on the solvent used. It is typically more soluble in organic solvents such as ethanol and methanol, and less soluble in polar solvents like water.
  • Molecular Structure Influence: The presence of ester functional groups, along with the bulky aromatic rings, can significantly affect its solubility properties.
  • Temperature Factor: Like many compounds, its solubility may increase with temperature, providing higher solubility in heated solvents compared to ambient conditions.
  • PH Sensitivity: The solubility might also be influenced by the pH of the solution, particularly due to the carboxylate group, which can ionize in more alkaline conditions to enhance solubility.

Due to the complex nature of its structure, predicting the exact solubility can be challenging. It’s essential to conduct empirical testing to fully understand the solubility characteristics of this compound in various environments.

Interesting facts

Interesting Facts about Ethyl 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-phenyl-piperidine-4-carboxylate

This intriguing compound, often associated with advancements in medicinal chemistry, showcases the complexity and creativity found in the design of pharmaceutical agents.

Key Features:

  • Complex Structure: The compound includes a piperidine backbone, which is essential in many psychoactive and therapeutic drugs, indicating potential biological activity.
  • Potential Therapeutic Uses: Due to its unique structure, researchers are investigating its usage in neuropharmacology, particularly for conditions such as depression and anxiety disorders.
  • Intriguing Substituents: The presence of a 5,6-dihydrobenzo[b][1]benzazepin moiety suggests interesting interactions within the central nervous system, opening pathways for innovative drug design.
  • Chirality Considerations: The compound may possess chiral centers, which implies that the enantiomers could exhibit different biological activities, a critical concept in pharmacodynamics.
  • Research and Development: As a subject of ongoing research, this compound reflects the dynamic nature of synthetic organic chemistry, where new methodologies in synthesis and characterization lead to enhanced understanding and new compounds of interest.

Quote: "The most exciting aspect of medicinal chemistry is the possibility of discovering new compounds that can provide therapeutic benefits not previously envisioned."

In summary, Ethyl 1-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-4-phenyl-piperidine-4-carboxylate is not just a compound; it's a representation of the heights that modern chemistry aspires to reach in addressing health challenges through innovative thinking and research endeavors.