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Loperamide hydrochloride

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Identification
Molecular formula
C29H33ClN2O5
CAS number
34552-83-5
IUPAC name
ethyl 1-(3-oxobutyl)-4-phenyl-piperidin-1-ium-4-carboxylate;chloride
State
State

At room temperature, Loperamide hydrochloride is in a solid state. It remains stable under normal conditions but must be stored in a dry place to avoid degradation.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
513.55g/mol
Molar mass
513.5450g/mol
Density
1.1000g/cm3
Appearence

The compound typically appears as a white or off-white crystalline powder. It is odorless and has a bitter taste. The powder may clump or become compacted over time if exposed to humidity.

Comment on solubility

Solubility of Ethyl 1-(3-oxobutyl)-4-phenyl-piperidin-1-ium-4-carboxylate;chloride

The solubility of ethyl 1-(3-oxobutyl)-4-phenyl-piperidin-1-ium-4-carboxylate;chloride can be influenced by several factors:

  • Polarity: This compound exhibits both polar and nonpolar characteristics due to the presence of the piperidin-1-ium group and the phenyl ring, affecting its interaction with solvents.
  • Solvent Type: It is likely to be soluble in polar solvents like water or alcohols but may show limited solubility in nonpolar organic solvents.
  • Temperature: As with most compounds, increasing the temperature tends to enhance solubility, making it more conducive for dissolution in various media.
  • pH Influence: The ionic nature of the compound might necessitate a specific pH for optimal solubility, as cationic species can be more soluble in certain pH conditions.

Overall, while the CH3 ethyl group tends to favor solubility in organic solvents, the CH4 carboxylate and chloride functionalities can enhance water solubility. Thus, evaluating the solubility characteristics of this compound in various solvents would provide more precise insights into its behavior in both laboratory and industrial environments.

Interesting facts

Interesting Facts about Ethyl 1-(3-oxobutyl)-4-phenyl-piperidin-1-ium-4-carboxylate; Chloride

Ethyl 1-(3-oxobutyl)-4-phenyl-piperidin-1-ium-4-carboxylate; chloride is a fascinating compound with numerous implications in both medicinal and chemical research. Here are some intriguing aspects:

  • Structural Complexity: This compound features a piperidinium core, which is typically associated with various pharmacologically active compounds. The presence of both ethyl and oxobutyl groups contributes to its structural diversity.
  • Potential Biological Activity: Compounds like this one may exhibit interesting biological properties. Researchers often investigate similar piperidinium derivatives for their potential use as analgesics or in the treatment of neurodegenerative diseases.
  • Quaternary Ammonium Nature: As a quaternary ammonium compound, its ionized form plays a critical role in interactions with biological membranes, potentially affecting its biological activity.
  • Research Applications: The synthesis and modification of compounds with piperidin-1-ium structures can lead to valuable insights into drug design and development. Scientists often use such compounds to explore structure-activity relationships.
  • Emerging Interests: With the rise in popularity of synthetic methods in organic chemistry, there is a growing interest in creating novel derivatives of complex compounds like this one to explore new therapeutic avenues.

This compound exemplifies the interplay between complex organic chemistry and potential real-world applications, making it a significant topic of study for chemists and pharmacologists alike.

Synonyms
16036-86-5
1-(3-Oxobutyl)-4-phenylisonipecotic acid ethyl ester hydrochloride
VUFB2809
ISONIPECOTIC ACID, 1-(3-OXOBUTYL)-4-PHENYL-, ETHYL ESTER, HYDROCHLORIDE