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Meperidine

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Identification
Molecular formula
C15H21NO2
CAS number
57-42-1
IUPAC name
ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate
State
State

At room temperature, Meperidine is typically found as a solid. Its crystalline form varies from one preparation to another; however, due care is necessary to handle it, as it is a compound often used in medical settings with specific dosing requirements.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
362.70
Boiling point (Kelvin)
635.85
General information
Molecular weight
247.33g/mol
Molar mass
247.3330g/mol
Density
1.0740g/cm3
Appearence

Meperidine is a white crystalline substance with a bitter taste. It may exist in different forms, such as a hydrochloride salt, which influences its appearance. It is typically odorless and is available in different forms like tablets, syrups, or as an injectable solution when used in medical applications.

Comment on solubility

Solubility of Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate

Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate (C15H21NO2) exhibits notable solubility characteristics that are influenced by its molecular structure. Here are some key points regarding its solubility:

  • Polarity: The presence of the carboxylate group contributes to the compound's polarity, which can enhance its solubility in polar solvents such as water.
  • Solvent Compatibility: It is generally more soluble in organic solvents like methanol and ethanol, owing to its ethyl group and aromatic ring that promote favorable interactions.
  • Temperature Dependence: As with many organic compounds, solubility can increase with temperature, allowing for better dissolution in various solvents as conditions change.

In practical applications, the solubility of this compound might be a crucial factor for its usability in different formulations, particularly in pharmaceuticals. Scientists often state that "a compound's solubility is a significant determinant of its bioavailability." Thus, understanding its solubility properties can provide significant insights into its functional behavior in biological systems.

In conclusion, while ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate may not be universally soluble in all environments, its amphiphilic nature allows for versatile interactions, making it an interesting subject of study in various chemical contexts.

Interesting facts

Interesting Facts about Ethyl 1-Methyl-4-Phenyl-Piperidine-4-Carboxylate

Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate, often referred to in shorthand as EMPP, belongs to a class of compounds that have garnered significant interest in medicinal chemistry. Here are some compelling points about this intriguing chemical compound:

  • Pharmacological Potential: EMPP has been studied for its potential applications in the treatment of various neurological conditions, displaying properties that could be beneficial for conditions such as Parkinson's Disease and depression.
  • Molecular Structure: The unique structure of EMPP, featuring both a piperidine ring and a carboxylate group, imparts specific steric and electronic characteristics that influence its biological activity.
  • Synthesis Pathways: Researchers have developed various synthetic pathways for EMPP, which not only optimize yield but also minimize environmental impact. This focus on green chemistry reflects a broader trend towards sustainable chemical practices.
  • Research Applications: Beyond its medicinal properties, EMPP serves as a key intermediate in the synthesis of other compounds, making it a valuable tool in organic synthesis and pharmaceutical research.
  • Regulatory Status: Ongoing studies of EMPP are essential to ensuring its safety and efficacy, which is paramount in the context of drug development and approval processes. The compound's profile must undergo rigorous testing before potential therapeutic use.

Overall, ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate embodies the intersection of organic chemistry and pharmacology, representing both the challenges and opportunities present in the quest for new medicinal compounds.

Synonyms
meperidine
Pethidine
Isonipecaine
Meperidol
Pethanol
Pethidineter
Demerol
Pethidin
Phetidine
Nemerol
Pipersal
57-42-1
Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
Petydyna
Petidina
Pethidinum
Ethyl 1-methyl-4-phenylisonipecotate
Renaudin
Demarol
Pethidine DBL
4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester
Methyl phenylpiperidine carbonic acid ethyl ester
Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester
N-Methyl-4-phenyl-4-carbethoxypiperidine
Pethidinum [INN-Latin]
Petidina [INN-Spanish]
1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester
HSDB 3116
1-Methyl-4-phenylisonipecotic acid, ethyl ester
meperidina
IDS-NP-001
EINECS 200-329-1
Pethidine (INN)
1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester
UNII-9E338QE28F
CHEBI:6754
9E338QE28F
1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester
CHEMBL607
DTXSID9023253
1-methyl-4-phenylisonipecotic acid ethyl ester
Pethidine [INN]
Meperidine-d5
Petydyna [Polish]
Isonipecain
Piperosal
Pethidinum (INN-Latin)
Petidina (INN-Spanish)
1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester
Pethidine DBL (TN)
Pethidine [INN:BAN]
Mepridine
DEA No. 9230
1-Methyl-4-phenyl-piperidin-4-carbon-saeure-aethylester [German]
Pethidinum (Latin)
Lidol (Salt/Mix)
Lydol (Salt/Mix)
Dolsin (Salt/Mix)
Dolaren (Salt/Mix)
Dolosal (Salt/Mix)
53484-75-6
Dispadol (Salt/Mix)
Dolantin (Salt/Mix)
Petantin (Salt/Mix)
Operidine (Salt/Mix)
Piridosal (Salt/Mix)
4-Carbethoxy-1-methyl-4-phenylpiperidine
Centralgin (Salt/Mix)
Dolcontral (Salt/Mix)
MEPERIDINE [MI]
MEPERIDINE [HSDB]
MEPERIDINE [VANDF]
PETHIDINE [WHO-DD]
SCHEMBL25431
DivK1c_000983
DTXCID403253
GTPL7221
KBio1_000983
N02AB02
NINDS_000983
YIsonipecotic acid, 1-methyl-4-phenyl-, ethyl ester (8CI)
BDBM50026752
DB00454
IDI1_000983
DB-053051
NS00009544
C07128
D08343
Pethidine (Meperidine) 0.1 mg/ml in Methanol
Pethidine (Meperidine) 1.0 mg/ml in Methanol
Q55434
4-Ethoxycarbonyl-1-methyl-4-phenyl-piperidinium
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate
L000908
SR-01000944492
SR-01000944492-1
1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester(Meperidine)
200-329-1