Skip to main content

Methylphenidate Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C14H20ClNO2
CAS number
298-59-9
IUPAC name
ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate;hydrochloride
State
State

At room temperature, methylphenidate hydrochloride is typically found in a solid state due to its crystalline powder form.

Melting point (Celsius)
224.00
Melting point (Kelvin)
497.15
Boiling point (Celsius)
136.00
Boiling point (Kelvin)
409.15
General information
Molecular weight
269.77g/mol
Molar mass
269.7700g/mol
Density
1.1000g/cm3
Appearence

Appearance: Methylphenidate hydrochloride typically appears as a white to off-white crystalline powder. It is known for its bitter taste.

Comment on solubility

Solubility of Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate; Hydrochloride

Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate; hydrochloride, identified by its chemical formula C14H20ClNO2, exhibits unique solubility characteristics that are crucial for its applications.

Key Points about Solubility:

  • Water Solubility: This compound is generally soluble in water due to the presence of the hydrochloride group, which enhances its ionic nature.
  • Solubility in Organic Solvents: It also shows considerable solubility in organic solvents such as ethanol and methanol, making it versatile for various formulations.
  • Temperature Effects: The solubility may increase with temperature, which is an important consideration in applications requiring concentration adjustments.
  • pH Dependence: Being a hydrochloride salt, its solubility can be affected by pH changes in the solution, often leading to better solubility in more acidic conditions.

In summary, the solubility profile of ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate; hydrochloride is notably influenced by its ionic nature, organic compatibility, and environmental conditions such as temperature and pH. Understanding these solubility aspects is essential for effective utilization in pharmaceutical and chemical applications.

Interesting facts

Interesting Facts about Ethyl 1-Methyl-4-Phenyl-Piperidine-4-Carboxylate Hydrochloride

This compound, ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate hydrochloride, is a fascinating member of the piperidine family, notable for its structural properties and potential applications in pharmacology. Here are some intriguing aspects of this compound:

  • Structural Diversity: The presence of both piperidine and phenyl groups provides this compound with a unique structural complexity, which can influence its chemical behavior and interactions significantly.
  • Pharmacological Interest: Compounds derived from piperidine have been the subject of extensive research due to their potential use in medicinal chemistry, particularly in the development of analgesics and anti-addiction therapies.
  • Biological Activity: Ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate hydrochloride may exhibit interesting biological activities, such as interactions with various neurotransmitter receptors, which could play a role in its effects on the central nervous system.
  • Synthesis Pathways: The synthesis of this compound can offer insights into the methodologies used in organic chemistry, leveraging reactions involving amines, esters, and substitutions to achieve the desired molecular structure.

Researchers have remarked, “The complexity of chemical compounds like this one often correlates with their biological efficacy and specificity.” This highlights the ongoing quest in medicinal chemistry to design compounds tailored for specific therapeutic targets.

As scientists explore the potential of ethyl 1-methyl-4-phenyl-piperidine-4-carboxylate hydrochloride, its multi-functional nature may lead to the discovery of new applications beyond the initial expectations, reinforcing the ever-evolving landscape of organic and medicinal chemistry.

Synonyms
MEPERIDINE HYDROCHLORIDE
Pethidine hydrochloride
50-13-5
Chlorbycyclen
Antiduol
Centralgin
Dispadol
Dolantal
Dolantin
Dolargan
Dolcontral
Dolestine
Dolaren
Dolosal
Algil
Dolin
Lidol
Meperidine Hcl
Antidurol
Doloneurine
Petantin
Piridosal
Dolenal
Dolenol
Mepadin
Petidin
Demerol hydrochloride
Pethidine chloride
Chlorbicyclene
Dolopethin
Pantalgine
Sauteralgyl
Spasmodolin
Endolat
Mephedine
Operidine
Spasmedal
Petantin hydrochloride
Meperitab
Synelaudine
Isonipecaine hydrochloride
Lydol
Alodan (gerot)
NIH 10522
Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride
(+-)-Pethidine hydrochloride
Clopedin
Dolantina
Doloblok
Meperdol
Opystan
Petholan
Petisel
Cluyer
G-Pethidine
Pethidine HCl
Petidin Dak
Ethyl 1-methyl-4-phenylisonipecotate hydrochloride
Ethyl-1-methyl-4-phenylisonipecotate hydrochloride
Meperidine hydrochloride cii
EINECS 200-013-3
1-Methyl-4-carbethoxy-4-phenylpiperidine hydrochloride
N-Methyl-4-phenyl-4-carbethoxypiperidine hydrochloride
WY 554
1-Methyl-4-phenyl-4-carboethoxypiperidine hydrochloride
NSC 400479
NSC-400479
UNII-N8E7F7Q170
1-Methyl-4-phenylisonipecotic acid ethyl ester hydrochloride
Ethyl 1-methyl-4-phenylpiperidyl-4-carboxylate hydrochloride
Pethidini hydrochloridum
N8E7F7Q170
4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride
S 140
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate;hydrochloride
Meperidine hydrochloride preservative free
Pethidine hydrochloride [JAN]
Mefedina
CHEBI:31984
DTXSID30950620
Meperidine hydrochloride [USAN:USP]
NSC400479
50-13-5 (HCl)
Dolsin
MEPERGAN COMPONENT MEPERIDINE HYDROCHLORIDE
Meperidine-d5 Hydrochloride
Meperidine.HCl (Pethidine.HCl)
4-(ethoxycarbonyl)-1-methyl-4-phenylpiperidinium chloride
Chlorbicyclene [French]
Meperidine hydrochloride (USAN:USP)
PETHIDINE HYDROCHLORIDE (MART.)
PETHIDINE HYDROCHLORIDE [MART.]
MEPERIDINE HYDROCHLORIDE CII (USP-RS)
MEPERIDINE HYDROCHLORIDE CII [USP-RS]
PETHIDINE HYDROCHLORIDE (EP IMPURITY)
PETHIDINE HYDROCHLORIDE [EP IMPURITY]
Pethidine Hydrochloride (1mg/ml in Methanol)
PETHIDINE HYDROCHLORIDE (EP MONOGRAPH)
PETHIDINE HYDROCHLORIDE [EP MONOGRAPH]
MEPERIDINE HYDROCHLORIDE (USP MONOGRAPH)
MEPERIDINE HYDROCHLORIDE [USP MONOGRAPH]
Dolantol
Meperidin
Demerol (TN)
Dolantin hydrochloride
55989-09-8
Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate,hydrochloride
CHEMBL1701
SCHEMBL41046
Meperidine hydrochloride (USP)
Pethidine hydrochloride (JP18)
DTXCID701378770
FDC18005
Isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride
MEPERIDINE HYDROCHLORIDE [MI]
MFCD00058210
1-Methyl-4-phenylpiperidine-4-carboxylic acid ethyl ester hydrochloride
WLN: T6NTJ A1 DVO2 DR &GH
FM25061
MEPERIDINE HYDROCHLORIDE [USAN]
MEPERIDINE HYDROCHLORIDE [VANDF]
PETHIDINE HYDROCHLORIDE [WHO-DD]
PETHIDINE HYDROCHLORIDE [WHO-IP]
DB-051733
Isonipecotic acid, ethyl ester, hydrochloride
NS00078332
MEPERIDINE HYDROCHLORIDE [ORANGE BOOK]
D01383
PETHIDINI HYDROCHLORIDUM [WHO-IP LATIN]
Pethidine Hydrochloride (Meperidine Hydrochloride)
MEPERIDINE HYDROCHLORIDE COMPONENT OF MEPERGAN
Q27284706
Piperidine, N-methyl-4-phenyl-4-carbethoxy-, hydrochloride
Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate monohydrochloride
Meperidine.HCl (Pethidine.HCl), 1mg/ml in Methanol (as free base)
1-Methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride
Dolvanolendolatethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride
Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate hydrochloride (1: 1)
1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester hydrochloride (1:1)
Meperidine hydrochloride, United States Pharmacopeia (USP) Reference Standard
1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester hydrochloride;1-Methyl-4-phenyl-isonipecotic acid ethyl ester hydrochlorid e;(+/-)-Pethidine hydrochloride
200-013-3