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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate
State
State

At room temperature, Lidocaine is typically in a solid state when pure, but it is often used in solution form for medical applications.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is typically found as a white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of Ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate

Ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate, a complex organic compound, exhibits unique solubility characteristics that are influenced by its functional groups and molecular structure. When considering the solubility of this compound, several factors come into play:

  • Polarity: The presence of a diethylamino group contributes to a degree of polarity, which could enhance solubility in polar solvents such as water, albeit to a limited extent.
  • Non-polar Characteristics: The ethyl and phenyl groups introduce non-polar characteristics, suggesting that this compound may also show good solubility in non-polar organic solvents like chloroform or ethanol.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the carbamoyl functional group may facilitate solubility in solvents that can act as hydrogen bond donors or acceptors.

In practical terms, it is often observed that:

  1. This compound may be sparingly soluble in water.
  2. It is likely to be soluble or miscible in various organic solvents.
  3. Temperature could significantly affect solubility; increasing temperature often enhances solubility in many solvents.

In conclusion, the solubility of ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate can be considered a balanced interplay of its polar and non-polar attributes, emphasizing the importance of solvent choice in practical applications. Understanding these solubility dynamics is essential for its effective utilization in laboratory and industrial settings.

Interesting facts

Interesting Facts about Ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate

Ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate is a fascinating compound within the field of organic chemistry, known for its distinctive structure and potential applications. Here are some engaging facts to consider:

  • Pharmacological Interest: This compound has garnered attention in medicinal chemistry due to its potential as a drug candidate. Its unique functional groups may contribute to biological activity, making it an intriguing subject for pharmaceutical research.
  • Synthetic Chemistry: The synthesis of ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate often involves intricate organic transformations. Chemists employ strategic pathways, utilizing various reagents and catalysts to achieve the desired molecular structure.
  • Structure-Activity Relationship (SAR): Researchers often investigate how modifications to the molecular structure impact biological efficacy. The presence of the diethylamino moiety can influence the compound’s properties, such as solubility and receptor binding affinity, highlighting the importance of SAR studies in drug development.
  • Potential Applications: Beyond pharmaceuticals, there is growing interest in the use of compounds with similar structures in fields like agrochemicals, where they may serve as herbicides or insecticides, showcasing their versatility.

As scientists continue to unveil the complexities of compounds like ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenyl-butanoate, they open doors to new discoveries that could lead to innovative solutions in medicine, agriculture, and beyond. The ongoing research in this area underscores the significance of organic compounds in contributing to advancements in various scientific domains.

Synonyms
Fenalamide
4551-59-1
Fenalamida
Femamide
ethyl 2-[2-(diethylamino)ethylcarbamoyl]-2-phenylbutanoate
Spasmamide
Fenalamide (USAN)
9D63492A3N
Ethyl N-(2-(diethylamino)ethyl)-2-ethyl-2-phenylmalonamate
FENALAMIDE [USAN]
Phemamide; SH 30858; Sch 5706; Spasmamide
Fenalamidum
Fenalamide [USAN:INN]
Fenalamidum [INN-Latin]
Fenalamida [INN-Spanish]
Sch 5706
EINECS 224-917-2
BRN 3992093
Ethyl N-[2-(diethylamino)ethyl]-2-ethyl-2-phenylmalonamate
Fenalamid
SH 30858
UNII-9D63492A3N
FENALAMIDE [MI]
FENALAMIDE [INN]
Phenylaethylmalonsaeure-aethylester-diaethylaminoaethyl-amid [German]
N-(2-(Diethylamino)ethyl)-2-ethyl-2-phenylmalonamic acid ethyl ester
FENALAMIDE [MART.]
Benzeneacetic acid, alpha-(((2-(diethylamino)ethyl)amino)carbonyl)-alpha-ethyl-, ethyl ester
FENALAMIDE [WHO-DD]
SCHEMBL24656
CHEMBL2106562
Ethyl N-(2-diethylaminoethyl)-2-phenyl-2-ethylmalonate
DTXSID60863416
Phenylaethylmalonsaeure-aethylester-diaethylaminoaethyl-amid
CHEBI:135421
MALONAMIC ACID, N-(2-(DIETHYLAMINO)ETHYL)-2-ETHYL-2-PHENYL-, ETHYL ESTER
NS00047948
D04138
Q27272382
ethyl N-(2-diethylaminoethyl) 2-phenyl-2-ethylmalonamate
Ethyl 2-{[2-(diethylamino)ethyl]carbamoyl}-2-phenylbutanoate
BENZENEACETIC ACID, .ALPHA.-(((2-(DIETHYLAMINO)ETHYL)AMINO)CARBONYL)-.ALPHA.-ETHYL-, ETHYL ESTER