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Flavokawain A

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Identification
Molecular formula
C18H13ClO6
CAS number
26683-63-6
IUPAC name
ethyl 3-(4-chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate
State
State

At room temperature, Flavokawain A is typically in a solid state. It is non-volatile and stable under normal conditions, which makes it suitable for various applications.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
368.75g/mol
Molar mass
368.7900g/mol
Density
1.4100g/cm3
Appearence

Flavokawain A generally appears as a yellow crystalline solid. Its appearance can be described as fine powder, crystal, or small aggregates of such crystals. Typically, the solid is homogeneous and displays a consistent yellow hue throughout.

Comment on solubility

Solubility of Ethyl 3-(4-chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate

The solubility of the compound ethyl 3-(4-chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate, with the chemical formula C18H13ClO6, can be characterized by several factors:

  • Polarity: The presence of hydroxyl (-OH) groups within the structure generally enhances solubility in polar solvents such as water. However, the overall non-polar character due to the chromene and chlorophenyl components can diminish this effect.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvents may facilitate dissolution. The dihydroxy groups can interact with water molecules, which may lead to increased solubility under certain conditions.
  • Solvent Interactions: The ability to dissolve in common organic solvents like ethanol, methanol, or acetone is likely due to the compound's hydrophobic regions interacting with these solvents.

In summary, the solubility of this compound may vary depending on the solvent used and the temperature conditions. Its unique structural features create a complex balance between hydrophilic and hydrophobic properties, making it essential to examine solubility empirically for accurate assessments. Further studies utilizing solubility tests in different solvents could provide more insights into its solubility behavior.

Interesting facts

Interesting Facts About Ethyl 3-(4-Chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate

Ethyl 3-(4-chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate is a fascinating compound that belongs to the chromene class of compounds, known for their diverse biological activities and applications in medicinal chemistry. Here are some intriguing aspects:

  • Complex Structure: This compound features a chromene backbone, which is a bicyclic structure that can be found in many natural products and synthetic biologically active compounds.
  • Pharmacological Potential: Chromene derivatives, including this compound, have been studied for their potential therapeutic effects, particularly in the fields of anti-inflammatory, antioxidant, and anticancer research.
  • Substituent Influence: The presence of the 4-chlorophenyl group significantly influences the compound's biological activity, as halogens often enhance lipophilicity, altering membrane permeability and bioactivity.
  • Natural Products: Compounds like this one may have analogues in natural products, especially from plants, where chromenes play a role in defensive and regulatory mechanisms.
  • Research Applications: Synthetic variations of this compound continue to attract chemists' interest, paving the way for the development of more potent analogues for therapeutic uses.

 

As chemists continue to explore the properties of ethyl 3-(4-chlorophenyl)-4,5-dihydroxy-7-oxo-chromene-2-carboxylate, it serves as a notable example of how synthetic organic chemistry can bridge the gap between chemical structure and biological function. One researcher aptly noted, "The study of chromenes offers a glimpse into the synergy of nature and chemistry, where diverse structures lead to exciting possibilities in drug discovery."