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Lidocaine

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Identification
Molecular formula
C14H22N2O2
CAS number
137-58-6
IUPAC name
ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate
State
State
Lidocaine is a solid at room temperature and can also be formulated into various solutions.
Melting point (Celsius)
66.00
Melting point (Kelvin)
339.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
234.34g/mol
Molar mass
234.3060g/mol
Density
1.0260g/cm3
Appearence

Lidocaine is usually a white or off-white solid powder. It is often provided in crystalline form for medical and laboratory use. In its pure form, this compound may appear as a colorless liquid as well when used in certain formulations. Lidocaine is typically odorless, or may have a very mild, characteristic odor.

Comment on solubility

Solubility of Ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate

Ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate, with the chemical formula C14H22N2O2, exhibits interesting solubility characteristics that are influenced by its molecular structure. Understanding the solubility of this compound not only aids in its practical applications but also provides insights into its chemical behavior. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydrophilic (polar) and hydrophobic (nonpolar) regions in the molecule contributes to its behavior in various solvents.
  • Water Solubility: It is expected to have low to moderate solubility in water due to the relatively large hydrophobic aromatic ring, counteracted slightly by the polar functional groups.
  • Organic Solvents: Ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate is likely to be more soluble in organic solvents such as ethanol, methanol, and acetone, where its hydrophobic regions can better interact with the solvent molecules.
  • Temperature Effect: Solubility can also be influenced by temperature; as temperature increases, solubility in organic solvents may improve.
  • “Like dissolves like”: This classic principle of solubility underscores how structures similar to the solvent promote solubility.

In summary, while ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate may not be highly soluble in water, its greater affinity for organic solvents opens up a range of possibilities for its use in chemical formulations and applications.

Interesting facts

Interesting Facts about Ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate

Ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate is a fascinating organic compound that belongs to the category of benzoate esters. Here are some intriguing aspects of this compound that highlight its significance in the world of chemistry:

  • Pharmaceutical Potential: The structure of this compound indicates potential pharmacological applications. Many compounds with similar structures are researched for their roles as drug candidates, particularly in areas related to analgesics and anti-inflammatory agents.
  • Functional Groups: The presence of an ester functional group provides this compound with unique chemical reactivity and properties. The benzoate component offers fascinating insights into how esters can be derived from aromatic acids.
  • Piperidine Influence: The inclusion of the piperidyl group is significant because piperidine derivatives are known for their versatility in medicinal chemistry, often contributing to the *biological activity* of a compound.
  • Versatile Synthesis: The synthesis of benzoate derivatives can often be achieved through various pathways, including esterification and acylation processes. Such versatility enables chemists to tailor compounds for specific applications.
  • Research Focus: As research continues in fields such as *medicinal chemistry* and *drug design*, compounds like ethyl 4-[[2-(1-piperidyl)acetyl]amino]benzoate are extensively studied for potential *bioactivity* and therapeutic benefits.

The exploration of compounds like this one opens doors to numerous possibilities in drug discovery, molecular pharmacology, and understanding how chemical structures relate to their functions in biological systems. Further research may reveal even more about its *unique applications* and *mechanistic insights* in pharmacology.

Synonyms
Ethyl piperidinoacetylaminobenzoate
41653-21-8
Sulcaine
ethyl 4-[(2-piperidin-1-ylacetyl)amino]benzoate
p-(Piperidinoacetamide)benzoic acid ethyl ester
Ethyl piperidinoacetylaminobenzoate [JAN]
DTXSID4048850
6M452G7O1F
NCGC00181909-01
Ethyl 4-(2-(piperidin-1-yl)acetamido)benzoate
Sulcain
Ethyl piperidinoacetylaminobenzoate (JAN)
Nichicaine
SA-7
Ethyl piperidylacetylaminobenzoate
Nichicaine (TN)
Sulcain (TN)
EPAB
Ethyl p-(piperidinoacetylamino)benzoate
BRN 1292603
EPAB [WHO-DD]
p-(2-Piperidinoacetamido)benzoic acid ethyl ester
MLS004774005
SCHEMBL510837
UNII-6M452G7O1F
CHEMBL2106245
DTXCID7028776
CHEBI:31576
QLGIFPJNYPWBMQ-UHFFFAOYSA-N
BENZOIC ACID, p-(2-PIPERIDINOACETAMIDO)-, ETHYL ESTER
ethyl p-piperidinoacetylaminobenzoate
Tox21_113334
AKOS001667375
Ethyl p-(2-piperidinoacetamido)benzoate
85404-18-8
SMR002529508
CAS-41653-21-8
EU-0013416
D01519
SBI-0142879.0001
5-20-03-00024 (Beilstein Handbook Reference)
ETHYL P-PIPERIDINOACETYLAMINOBENZOATE [MART.]
Q27265136
Z46157680