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Pyrimethamine

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Identification
Molecular formula
C12H34N4O2
CAS number
58-14-0
IUPAC name
ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate
State
State

At room temperature, pyrimethamine is generally in a solid state. It should be stored in a properly closed container to maintain its integrity and prevent moisture ingress.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
248.71g/mol
Molar mass
0.0000g/mol
Density
1.3000g/cm3
Appearence

Pyrimethamine typically appears as an off-white to yellow crystalline powder. It is relatively stable and has a fine particulate texture. The coloration might vary slightly due to different conditions of storage and age.

Comment on solubility

Solubility of Ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate

Ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate, often referred to simply as this lengthy compound name, presents a fascinating study in solubility characteristics due to its complex structure. The solubility of such organic compounds is influenced by various factors that can determine their behavior in solvents.

Key Solubility Considerations:

  • Solvent Polarity: The ability of this compound to dissolve is greatly affected by the polarity of the solvent. Polar solvents like water may not effectively dissolve this compound, while non-polar solvents like hexane could show better compatibility.
  • Functional Groups: The presence of numerous amino groups (-NH2) can indicate potential for hydrogen bonding, which may improve solubility in polar solvents. However, steric hindrance and large non-polar regions can counteract this effect.
  • Temperature: Increasing temperature typically enhances solubility for many organic compounds. Therefore, higher temperatures may improve the solubility of ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate in various solvents.

While definitive solubility data may vary, it is important to note that the structural complexity of this compound can lead to variability in solubility outcomes depending on the solvent system and conditions utilized in testing.

In summary, understanding the solubility characteristics of ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate opens up avenues for practical applications, making it crucial for scientists to explore tailored solvent systems in order to optimize dissolution.

Interesting facts

Interesting Facts about Ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate

Ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate is a fascinating compound notable for its complex structure and potential applications in medicinal chemistry. Here are some intriguing insights:

  • Versatile Applications: This compound may exhibit properties that can be beneficial in the development of pharmaceutical agents, particularly in targeting cancer therapy and antimicrobial treatments.
  • Chemical Diversity: The presence of multiple functional groups, such as amino and azobenzene moieties, enhances the compound's reactivity and opens pathways to create numerous derivatives for further studies.
  • Structure-Activity Relationship (SAR): By examining the structure of this compound, researchers can investigate how the activity changes with variations in substituents. This is crucial in drug design and optimization.
  • Research Potential: Scientists are increasingly interested in azobenzene compounds because of their ability to undergo reversible photoisomerization, which can be harnessed in smart materials and therapeutic tools.
  • Biological Mechanisms: Understanding the mechanism by which this compound interacts with biological systems could lead to interdisciplinary advancements between chemistry, biology, and medicine.

In summation, ethyl 4-[2,4-diamino-6-(3-anilinopropylamino)pyrimidin-5-yl]azobenzoate represents a vibrant intersection of chemistry and potential therapeutic solutions. The collaborative efforts between chemists and biologists could pave the way for innovative breakthroughs that challenge the limits of current treatment methodologies.

Synonyms
Benzoic acid, 4-((2,4-diamino-6-(3-anilino)propylamino)pyrimidin-5-yl)azo-, ethyl ester
7313-47-5
2,4,6-Triamino-5-(4-carbethoxyphenylazo)-6-N-(3-anilino)propylpyrimidine
4-((2,4-Diamino-6-(3-anilino)propylamino)pyrimidin-5-yl)azobenzoic acid ethyl ester