Perphenazine | Solubility of Things

Identification

Molecular formula

C₂₁H₂₆ClN₃OS

CAS number

58-39-9

IUPAC name

ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate

State

Perphenazine is generally found as a solid at room temperature, usually dispensed in tablet form for medication purposes.

Melting point (Celsius)

92.50

Melting point (Kelvin)

365.65

Boiling point (Celsius)

513.20

Boiling point (Kelvin)

786.35

General information

Molecular weight

403.97g/mol

Molar mass

403.0530g/mol

Density

1.3510g/cm³

Appearence

Perphenazine is a pale yellow crystalline powder that may appear off-white. It is typically stored in its hydrochloride form for medical use, appearing as a white or slightly creamy powder.

Comment on solubility

Solubility of Ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate

The solubility of the compound ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate is influenced by various factors, including its molecular structure and the presence of functional groups. Here are some critical points regarding its solubility:

Polarity: The presence of both polar and nonpolar components in the molecule can lead to a moderate degree of solubility in different solvents. Polar solvents, like water, may support limited solubility due to the hydrophobic characteristics of the phenothiazine moiety.
Solvent Compatibility: This compound is more likely to dissolve in polar organic solvents such as ethanol or acetone rather than in nonpolar solvents, owing to its hybrid nature.
Hydrophobic Effects: The bulky cyclohexanecarboxylate structure enhances its hydrophobic character, often resulting in lower solubility in aqueous solutions.

In summary, while ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate may exhibit some solubility in polar organic solvents, it is generally expected to have low solubility in water due to its hydrophobic functionalities. Thus, it’s essential to consider the solvent system when evaluating its solubility for practical applications.

Interesting facts

Interesting Facts about Ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate

Ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate is a fascinating compound that belongs to a class of organic molecules known for their diverse applications, particularly in medicinal chemistry. Here are some intriguing aspects to consider:

Pharmacological Significance: This compound is a derivative of phenothiazine, a structure that has been widely explored in the development of antipsychotic medications. It showcases the potential for various therapeutic effects, making it a noteworthy candidate for further research.
Structural Features: The compound comprises a cyclohexanecarboxylate moiety, which contributes to its bulk and influences its pharmacokinetic properties. The presence of multiple aromatic rings enhances its ability to interact with biological targets.
Synthesis Potential: The complex structure provides a rich field for synthetic chemists. Its synthesis can help develop new techniques and methodologies in organic chemistry, paving the way for new compounds with enhanced efficacy and reduced side effects.
Drug Design: The ability to modify the ethyl and phenyl groups allows scientists to tailor the compound for specific receptors, making it an exciting subject for drug discovery and design. Such modifications can lead to compounds with improved selectivity and activity.
Versatility: Beyond its medicinal properties, compounds like ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate can find applications in the fields of agriculture and materials science, especially if further functionalization is achieved.

In summary, ethyl 4-(3-phenothiazin-10-ylpropyl)-1-phenyl-cyclohexanecarboxylate is a compound with a unique structure and significant potential in various scientific realms. As research progresses, it may unveil new applications and broaden our understanding of phenothiazine derivatives.