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Ethylparaben

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Identification
Molecular formula
C9H10O3
CAS number
120-47-8
IUPAC name
ethyl 4-hydroxybenzoate
State
State

At room temperature, Ethylparaben is solid. It is stable under normal temperatures and pressures.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
297.00
Boiling point (Kelvin)
570.15
General information
Molecular weight
166.17g/mol
Molar mass
166.1730g/mol
Density
1.1690g/cm3
Appearence

Ethylparaben is a white, crystalline powder or colorless crystals. It can also appear as a fine, white or almost white powder. It is known to have a faint characteristic odor.

Comment on solubility

Solubility of Ethyl 4-Hydroxybenzoate

Ethyl 4-hydroxybenzoate, known for its applications in the pharmaceutical and cosmetic industries, exhibits interesting solubility characteristics:

  • Solubility in Water: Ethyl 4-hydroxybenzoate is only slightly soluble in water, a trait attributed to its hydrophobic ethyl group, which limits its interactions with polar water molecules.
  • Solubility in Organic Solvents: This compound shows greater solubility in organic solvents such as ethanol, methanol, and acetone. This behavior is primarily due to the compatibility of ethyl 4-hydroxybenzoate with non-polar or less polar solvents.
  • Factors Affecting Solubility: The solubility can be influenced by:
    • Temperature: Increased temperature may enhance solubility in both water and organic solvents.
    • pH: As a weak acid, the solubility can change with pH variations, affecting its ionization state and, consequently, its solubility profile.

In summary, while ethyl 4-hydroxybenzoate has limited solubility in water, its solubility in organic solvents makes it a versatile compound in various formulations. Understanding these solubility characteristics is key when working with this compound in practical applications.

Interesting facts

Interesting Facts about Ethyl 4-Hydroxybenzoate

Ethyl 4-hydroxybenzoate, often referred to as ethylparaben, is an intriguing compound that belongs to the paraben family. These compounds are widely used as preservatives in food, cosmetics, and pharmaceuticals. Here are some fascinating insights about ethyl 4-hydroxybenzoate:

  • Natural Occurrence: Ethyl 4-hydroxybenzoate can be found in a variety of natural sources, including certain fruits and vegetables, which highlights its role in nature.
  • Antimicrobial Properties: One of the key features of this compound is its ability to inhibit the growth of bacteria and fungi, making it a valuable ingredient in products that require a long shelf life.
  • Chemical Structure: The compound consists of an ethyl group attached to the 4-position of a hydroxybenzoate structure. This unique architecture contributes to its functionality as a preservative.
  • Safety and Regulation: Ethylparaben has been deemed safe for use in cosmetic and food products by several regulatory agencies, including the FDA and the European Food Safety Authority (EFSA), as long as it's used within established guidelines.
  • Alternative Uses: Beyond preservation, ethyl 4-hydroxybenzoate is sometimes employed in the formulation of aroma compounds due to its subtle fruity scent.

With its proven efficacy and safety profile, ethyl 4-hydroxybenzoate plays a crucial role in various industries, demonstrating the importance of synthetic compounds in our daily lives. As students and scientists, understanding such compounds allows for advancements in product formulations that can benefit society at large.

Synonyms
Ethylparaben
ETHYL 4-HYDROXYBENZOATE
120-47-8
Ethyl paraben
Ethyl p-hydroxybenzoate
Tegosept E
Ethyl parahydroxybenzoate
Mycocten
4-Hydroxybenzoic acid ethyl ester
Ethyl parasept
Aseptoform E
Nipagin A
Easeptol
Ethyl p-oxybenzoate
Ethyl butex
p-Hydroxybenzoic acid ethyl ester
Napagin A
Nipazin A
Solbrol A
Sobrol A
Benzoic acid, 4-hydroxy-, ethyl ester
p-Carbethoxyphenol
Ethyl-p-hydroxybenzoate
Mekkings E
Aseptin A
Bonomold OE
9001-05-2
Ethyl-4-hydroxybenzoate
Ethyl para-hydroxybenzoate
p-Oxybenzoesaeureaethylester
4-Hydroxy-benzoic acid ethyl ester
4-Carbethoxyphenol
NSC 23514
p-Hydroxybenzoate ethyl ester
Ethylparaben [NF]
Benzoic acid, p-hydroxy-, ethyl ester
E214
4-Hydroxybenzoic acid, ethyl ester
Ins no.214
4-(Ethoxycarbonyl)phenol
Para-hydroxybenzoic acid ethyl ester
Ethylester kyseliny p-hydroxybenzoove
MFCD00002353
NSC-23514
Ins-214
Ester etylowykwasu p-hydroksybenzoesowego
Ethyl parahydroxybenzoate e214
DTXSID9022528
E-214
4-hydroxybenzoic acid-ethyl ester
Ethylparaben (NF)
14255EXE39
NCGC00160654-01
ethyl-paraben
Carbethoxyphenol
WLN: QR DVO2
DTXCID002528
Caswell No. 447
p-Hydroxybenzoic acid, ethyl ester
4-Hydroxybenzoic acid-ethyl ester 1000 microg/mL in Acetonitrile
CAS-120-47-8
HSDB 938
EINECS 204-399-4
p-Oxybenzoesaeureaethylester [German]
EPA Pesticide Chemical Code 061202
BRN 1101972
Ethyl chemosept
AI3-30960
Aseptine a
Nipagina A
Ethylester kyseliny p-hydroxybenzoove [Czech]
UNII-14255EXE39
Ester etylowykwasu p-hydroksybenzoesowego [Polish]
Ethylis hydroxybenzoas
Ethylparaben (Standard)
Ethyl 4-hydroxy-benzoate
ETHYLPARABEN [II]
ETHYLPARABEN [MI]
Ethyl 4-hydroxyl-benzoate
Ethylparaben, INN, USAN
bmse010255
EC 204-399-4
ETHYLPARABEN [HSDB]
p-Hydroxybenzoic ethyl ester
SCHEMBL28368
4-10-00-00367 (Beilstein Handbook Reference)
BIDD:ER0023
CHEMBL15841
ETHYLPARABEN [USP-RS]
Ethyl parahydroxybenzoate (TN)
ethyl 4-hydroxybenzenecarboxylate
CHEBI:31575
HY-B0934R
NSC8510
Ethyl parahydroxybenzoate (JP17)
HMS2091E17
Parahydroxybenzoic acid ethyl ester
Pharmakon1600-01400151
4-hydroxy benzoic acid ethyl ester
HY-B0934
NSC-8510
NSC23514
Tox21_111961
Tox21_300335
BBL012166
BDBM50428380
NSC755851
s4525
STK070911
ETHYL HYDROXYBENZOATE [MART.]
AKOS000120512
ETHYL HYDROXYBENZOATE [WHO-DD]
ETHYL HYDROXYBENZOATE [WHO-IP]
Tox21_111961_1
CCG-213682
CS-4403
DB13628
ETHYL PARAHYDROXYBENZOATE [JAN]
FE23063
NSC-755851
NCGC00160654-02
NCGC00160654-03
NCGC00160654-04
NCGC00160654-06
NCGC00254462-01
AC-11586
AC-34532
AS-11988
DA-73229
NCI60_041866
SBI-0206674.P002
ETHYL ESTER OF P-HYDROXYBENZOIC ACID
E0884
ETHYLIS HYDROXYBENZOAS [WHO-IP LATIN]
H0211
NS00008316
EN300-16106
D01647
Ethyl 4-hydroxybenzoate, ReagentPlus(R), 99%
ETHYL PARAHYDROXYBENZOATE [EP IMPURITY]
ETHYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
W18471
AB00375765_03
AE-646/31213037
Q229976
SR-05000001552
SR-05000001552-1
BRD-K02464583-001-01-4
BRD-K02464583-001-02-2
Ethyl 4-hydroxybenzoate, SAJ first grade, >=99.0%
PROPYL HYDROXYBENZOATE IMPURITY C [EP IMPURITY]
Z53833636
Ethyl 4-hydroxybenzoate, Vetec(TM) reagent grade, 99%
Ethylparaben, certified reference material, TraceCERT(R)
F0728-0009
4-Hydroxybenzoic acid ethyl ester;4-(Ethoxycarbonyl)phenol
METHYL PARAHYDROXYBENZOATE IMPURITY B [EP IMPURITY]
Ethylparaben, United States Pharmacopeia (USP) Reference Standard
Ethyl parahydroxybenzoate, European Pharmacopoeia (EP) Reference Standard
Ethylparaben, Pharmaceutical Secondary Standard; Certified Reference Material
InChI=1/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H
E4B