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Ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate

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Identification
Molecular formula
C20H29NO3
CAS number
96839-55-9
IUPAC name
ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate
State
State

At room temperature, ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate is in a solid state. It is typically stored in a cool, dry place to maintain its stability and prevent decomposition.

Melting point (Celsius)
72.60
Melting point (Kelvin)
345.75
Boiling point (Celsius)
360.20
Boiling point (Kelvin)
633.35
General information
Molecular weight
331.45g/mol
Molar mass
331.4540g/mol
Density
1.1745g/cm3
Appearence

Ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate is a crystalline solid. It typically appears as a white or off-white powder at room temperature. The appearance may vary slightly depending on the purity and specific handling conditions of the compound.

Comment on solubility

Solubility of Ethyl 4-Phenyl-1-(3-Tetrahydrofuran-2-Ylpropyl)piperidine-4-Carboxylate

Understanding the solubility of ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate is pivotal for its applications in pharmaceutical and chemical processes. The solubility characteristics of a compound greatly influence its behavior in biological systems and formulations. Here are some key points to consider:

  • Polarity: The presence of multiple functional groups in the structure, including a carboxylate moiety, suggests that the compound may exhibit some level of polarity, potentially increasing its solubility in polar solvents like water.
  • Nonpolar Interactions: The ethyl and phenyl groups can enhance solubility in nonpolar solvents such as hexane or ether, indicating a dual affinity for both polar and nonpolar environments.
  • Temperature Influence: As with many organic compounds, solubility may increase with temperature. This is particularly relevant when considering solutions for experimental or industrial use.
  • Solvent Choice: For optimal solubility, solvents should be chosen based on their ability to solvate the polar and nonpolar regions of the compound effectively.

In conclusion, while precise solubility data for ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate may vary based on experimental conditions, understanding its polarity and functional groups can provide valuable insights into its behavior in various solvents. As noted, "the solubility of a compound is a key determinant in its reactivity and applicability."

Interesting facts

Interesting Facts About Ethyl 4-Phenyl-1-(3-Tetrahydrofuran-2-Ylpropyl)piperidine-4-Carboxylate

Ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate is a fascinating compound within the realm of organic chemistry. Below are some intriguing details regarding its structure and potential applications:

  • Structural Complexity: This compound features a piperidine ring, which is a six-membered ring containing a nitrogen atom. The presence of both ethyl and phenyl groups introduces remarkable diversity in its chemical properties.
  • Tetrahydrofuran Influence: The inclusion of a tetrahydrofuran moiety lends unique characteristics to the compound, notably in terms of its stereochemistry and reactivity. This segment not only contributes to the overall structure but may also influence biological activity.
  • Potential Biological Activity: Compounds like this one are of great interest in medicinal chemistry due to their potential effects on the central nervous system. Research is ongoing to investigate their role as anxiolytics or analgesics.
  • Synthesis Challenges: The synthesis of such complex compounds typically involves multiple steps, requiring sophisticated techniques in organic synthesis. Understanding the synthesis pathway can provide insight into how structural modifications lead to varied pharmacological properties.
  • Applications in Drug Design: The structural features of ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate may inspire the design of new pharmaceuticals. Its shape and functional groups can interact with biological targets in specific ways, making it a candidate for further exploration in drug development.

As a compound that bridges the gap between structural chemistry and pharmacology, ethyl 4-phenyl-1-(3-tetrahydrofuran-2-ylpropyl)piperidine-4-carboxylate serves as a potent example of how organic compounds pave the way for advancements in medicine and therapeutic interventions.

Synonyms
TA 98
BRN 0439755
2260-45-9
4-Phenyl-1-(3-(tetrahydro-2-furyl)propyl)isonipecotic acid ethyl ester
4-Piperidinecarboxylic acid, 4-phenyl-1-(3-(tetrahydro-2-furanyl)propyl)-, ethyl ester
ISONIPECOTIC ACID, 4-PHENYL-1-(3-(TETRAHYDRO-2-FURYL)PROPYL)-, ETHYL ESTER
5-22-02-00494 (beilstein handbook reference)
ethyl 1-[3-(oxolan-2-yl)propyl]-4-phenylpiperidine-4-carboxylate
DTXSID30945258