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Cocaine

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Identification
Molecular formula
C17H21NO4
CAS number
50-36-2
IUPAC name
ethyl 4-phenyl-1-(5-tetrahydrofuran-2-ylpentyl)piperidine-4-carboxylate
State
State

At room temperature, cocaine is typically found as a solid in its hydrochloride salt form. In its base form, known as 'crack', it appears as small crystalline or rock-like masses.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.00
Boiling point (Celsius)
187.00
Boiling point (Kelvin)
460.00
General information
Molecular weight
303.35g/mol
Molar mass
303.3530g/mol
Density
1.0220g/cm3
Appearence

Cocaine typically appears as a white, crystalline powder. It is often used illicitly and may be mixed with other substances, altering its appearance somewhat. The pure compound, however, maintains its powdery, white crystalline form.

Comment on solubility

Solubility of Ethyl 4-phenyl-1-(5-tetrahydrofuran-2-ylpentyl)piperidine-4-carboxylate

The solubility of ethyl 4-phenyl-1-(5-tetrahydrofuran-2-ylpentyl)piperidine-4-carboxylate is a nuanced aspect that can greatly influence its application in various chemical processes. As a complex organic molecule, its solubility is determined by several factors, including:

  • Polarity: The presence of polar groups can enhance solubility in polar solvents like water.
  • Hydrogen Bonding: Capable of forming hydrogen bonds, this compound may exhibit better solubility in solvents that can donate hydrogen bonds.
  • Molecular Structure: The bulky aromatic and aliphatic structures may limit solubility in some media.
  • Temperature: Increasing temperature may improve solubility for many organic compounds.

When considering solubility, it is critical to remember that:

  1. Solvent Interaction: The compound's compatibility with specific solvents should be assessed, as it may greatly differ between hydrocarbon and polar solvents.
  2. Concentration and pH: Variability in pH can affect ionization and, consequently, solubility.

In conclusion, while the solubility of ethyl 4-phenyl-1-(5-tetrahydrofuran-2-ylpentyl)piperidine-4-carboxylate may not be straightforward, understanding these factors can provide valuable insights for applications in pharmaceuticals, materials science, and chemical synthesis. Always consult detailed solubility charts or perform empirical tests for accurate assessments.

Interesting facts

Interesting Facts about Ethyl 4-Phenyl-1-(5-Tetrahydrofuran-2-Ylpentyl)piperidine-4-Carboxylate

Ethyl 4-phenyl-1-(5-tetrahydrofuran-2-ylpentyl)piperidine-4-carboxylate is an intriguing compound that belongs to the class of piperidine derivatives, known for their diverse biological activities and potential therapeutic applications. Here are some fascinating aspects worth noting:

  • Structural Complexity: This compound exemplifies structural complexity due to its piperidine core combined with a phenyl group and a tetrahydrofuran moiety. This unique structure contributes to its potential interactions with biological targets.
  • Pharmacological Potential: Compounds featuring piperidine rings are often studied for their neuropharmacological properties. They can function as analgesics, antidepressants, or even as agents in the treatment of various neurodegenerative diseases.
  • Intriguing Substituents: The presence of a tetrahydrofuran ring adds rigidity and may enhance the binding affinity to certain receptors within the central nervous system. This modification can lead to improved pharmacological profiles.
  • Research Initiatives: Current research initiatives aim to explore the dynamics of how such compounds bind to neurotransmitter receptors and their potential roles in modulating mood and cognition.
  • Natural and Synthetic Sources: While certain piperidine derivatives are found in nature, many are synthesized in laboratories, allowing chemists to tailor their properties for specific applications.

This compound stands as a testament to the continual exploration in medicinal chemistry, where new compounds are persistently synthesized and investigated for their therapeutic potential. The pursuit of understanding the nuances of such compounds not only advances scientific knowledge but also holds promise for future drug development.

Synonyms
TA 108
BRN 0445043
3542-78-7
4-Phenyl-1-(5-(tetrahydro-2-furyl)pentyl)isonipecotic acid ethyl ester
ISONIPECOTIC ACID, 4-PHENYL-1-(5-(TETRAHYDRO-2-FURYL)PENTYL)-, ETHYL ESTER
5-22-02-00494 (beilstein handbook reference)
ethyl 1-[5-(oxolan-2-yl)pentyl]-4-phenylpiperidine-4-carboxylate
DTXSID10956822