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Ethyl 4-phenylpiperidine-4-carboxylate

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Identification
Molecular formula
C14H19NO2
CAS number
1202-34-2
IUPAC name
ethyl 4-phenylpiperidine-4-carboxylate
State
State

At room temperature, ethyl 4-phenylpiperidine-4-carboxylate is typically in a solid state. It forms well-defined crystals and remains stable when not exposed to moisture or extreme environmental conditions.

Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
300.50
Boiling point (Kelvin)
573.65
General information
Molecular weight
233.31g/mol
Molar mass
233.3110g/mol
Density
1.0910g/cm3
Appearence

Ethyl 4-phenylpiperidine-4-carboxylate typically appears as a white to off-white crystalline powder. It is not known to have any characteristic odor, making its detection straightforward through visual and textural means in most laboratory contexts.

Comment on solubility

Solubility of Ethyl 4-phenylpiperidine-4-carboxylate

Ethyl 4-phenylpiperidine-4-carboxylate, a compound appreciated in the field of organic chemistry, demonstrates specific solubility characteristics that are essential for its application. When assessing its solubility, consider the following key points:

  • Polar vs. Non-polar Solvents: This compound generally exhibits limited solubility in water due to its non-polar phenyl ring, yet it is soluble in organic solvents such as ethanol, chloroform, and acetone.
  • Temperature Effects: Solubility can be influenced by temperature; increasing the temperature often enhances solubility in non-polar solvents, making it easier to dissolve the compound in high-temperature reactions.
  • pH Considerations: Modifying the pH of the solution may affect ionization states and, consequently, the solubility—alkaline conditions can improve solubility for certain piperidine derivatives.
  • Concentration: High concentrations of ethyl 4-phenylpiperidine-4-carboxylate can lead to precipitation, underscoring the importance of controlling dosage for optimal solubility.

In summary, while ethyl 4-phenylpiperidine-4-carboxylate may not be readily soluble in water, understanding its interactions with various solvents and conditions can significantly enhance its use in chemical applications. Remember, "the key to solubility is knowing your solvent!"

Interesting facts

Ethyl 4-phenylpiperidine-4-carboxylate: An Insight into the Compound

Ethyl 4-phenylpiperidine-4-carboxylate is a fascinating compound that holds significance in various fields of research, particularly in medicinal chemistry and pharmacology. This compound is known for its potential applications and unique structural attributes.

Key Features

  • Pharmacological Interest: Ethyl 4-phenylpiperidine-4-carboxylate is often studied for its effects on the central nervous system, making it a subject of exploration in the development of analgesics and other therapeutic agents.
  • Synthetic Versatility: The compound's structure allows for various synthetic pathways, which can lead to the discovery of novel derivatives. This versatility is key for chemists aiming to customize properties for specific applications.
  • Structural Components: It features a piperidine ring, which is a common motif in many biologically active compounds. The addition of a phenyl group enhances its hydrophobic characteristics, potentially influencing the compound's interaction with biological macromolecules.

Applications and Research Directions

This compound exemplifies how small changes in chemical structure can lead to significant biological effects. Current research is focusing on:

  • The exploration of its analgesic properties.
  • Its potential as a template for designing new psychiatric medications.
  • Understanding its mechanism of action within the nervous system.

As chemists and researchers continue to investigate the myriad possibilities of ethyl 4-phenylpiperidine-4-carboxylate, it underscores the importance of chemical compounds in developing therapeutic strategies and contributing to the advancement of health sciences. As one researcher aptly put it, *"Every compound tells a story, and this one is just beginning to unfold."*

Synonyms
Ethyl 4-phenylpiperidine-4-carboxylate
Normeperidine
Norpethidine
77-17-8
Nordolsin
4-Piperidinecarboxylic acid, 4-phenyl-, ethyl ester
JG096PMW2N
IDS-NP-003
DTXSID50227806
NSC-23821
PETHIDINE-INTERMEDIATE-B, ETHYL-4-PHENYLPIPERIDINE-4-CARBOXYLATE
RefChem:166645
DTXCID60150297
201-008-9
4-Carbethoxy-4-phenylpiperidine
Ethyl 4-phenylisonipecotate
4-Phenyl-4-carbethoxypiperidine
4-(Ethoxycarbonyl)-4-phenylpiperidine
4-Phenylpiperidine-4-carboxylic acid ethyl ester
Isonipecotic acid, 4-phenyl-, ethyl ester
CHEMBL1052
PETHIDINE INTERMEDIATE B
Ethyl 4-phenyl-4-piperidinecarboxylate
Ethyl-4-phenylpiperidine-4-carboxylate
4-Phenyl-piperidine-4-carboxylic acid ethyl ester
UNII-JG096PMW2N
EINECS 201-008-9
N-DESMETHYLMEPERIDINE
Pethidine - Intermediate-B
Norpethidine (Normeperidine)
SCHEMBL341796
SCHEMBL6869543
DEA No. 9233
4-phenyl-4-carboethoxy-piperidine
4-ethoxycarbonyl-4-phenylpiperidine
BDBM50071692
SBB012986
STK689062
AKOS005601310
NCGC00160433-01
AS-37791
Ethyl 4-phenyl-4-piperidinecarboxylate #
ST087418
DB-075255
NS00010413
C22685
Norpethidine (Normeperidine) 0.1 mg/ml in Methanol
Q7053200
Isonipecotic acid, 4-phenyl-, ethyl ester (6CI,7CI,8CI)