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Tafenoquine

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Identification
Molecular formula
C24H28N2O5
CAS number
106635-80-7
IUPAC name
ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] carbonate
State
State

At room temperature, tafenoquine is in a solid state. The compound is stable under normal conditions but must be handled in accordance with proper safety procedures to prevent inhalation or ingestion.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.15
Boiling point (Celsius)
433.70
Boiling point (Kelvin)
706.85
General information
Molecular weight
463.59g/mol
Molar mass
463.5860g/mol
Density
1.2800g/cm3
Appearence

Tafenoquine is a solid compound that appears as a white to slightly off-white crystalline powder. It is practically insoluble in water, freely soluble in acetone, and very slightly soluble in methanol. Its crystalline nature and slight off-white coloration can be characteristic for many quinoline derivatives.

Comment on solubility

Solubility of Ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] Carbonate

Ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] carbonate, with the chemical formula C24H28N2O5, presents an intriguing profile when it comes to solubility. This compound exhibits characteristics that can significantly influence its dissolution in various solvents.

Key Factors Influencing Solubility:

  • Polarity: The presence of multiple functional groups, including the carbonate moiety, suggests partial polarity which may enhance its solubility in polar solvents.
  • Hydrogen Bonding: Ability to form hydrogen bonds can lead to increased solvation in appropriate solvents, particularly in alcohols or water.
  • Molecular Size: Given its larger structural framework, solubility may diminish in non-polar solvents, tending to maintain preference for polar or semi-polar environments.

In practical applications, the solubility of this compound can be summarized as:

  1. Likely soluble in: Alcohols, dimethyl sulfoxide (DMSO), and potentially aqueous environments with suitable pH.
  2. Poorly soluble in: Non-polar solvents such as hexane or cyclohexane.
  3. Consideration: Temperature may also play a critical role, with increased thermal conditions potentially enhancing solubility.

In conclusion, understanding the solubility dynamics of ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] carbonate not only aids in practical applications but also paves the way for further research into its interactions and effectiveness in various chemical environments.

Interesting facts

Interesting Facts about Ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] Carbonate

This intriguing compound, ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] carbonate, exhibits several noteworthy characteristics that fascinate both chemists and students alike. It serves as a quintessential example of how structural complexity can lead to diverse biological activities. Here are some interesting aspects surrounding this compound:

  • Pharmacological Potential: The presence of quinoline and quinuclidine structures suggests potential implications in pharmaceuticals, particularly in medicinal chemistry, where they might be explored for their therapeutic properties.
  • Quinoline Derivatives: Many compounds containing quinoline motifs are known for their antibacterial, antifungal, and anti-inflammatory properties, which could make this compound a candidate for further investigations.
  • Versatile Functional Groups: The carbonate group is integral in organic synthesis and drug development, acting as a versatile link in creating more complex molecules. Its reactivity can potentially lead to various derivatives that could enhance biological efficacy.
  • Research Applications: Owing to its unique structure, researchers could exploit this compound to develop novel materials or even as a catalyst in organic reactions.
  • Green Chemistry: The combined presence of functional groups in this compound opens avenues for green chemistry applications, where it can potentially be used in sustainable processes due to its organic nature.

In summary, the compound ethyl [(6-methoxy-4-quinolyl)-(5-vinylquinuclidin-2-yl)methyl] carbonate is not only a fascinating subject due to its structural intricacies but also because of the potential horizons it opens in pharmacology and organic chemistry. As stated by a renowned chemist, "Innovation in chemistry often arises from the most unexpected combinations of atoms."

This compelling compound exemplifies that innovation and its vast possibilities.

Synonyms
QUININE ETHYL CARBONATE
[(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methyl] ethyl carbonate
Aecachinium; Euquinin; Euquinine
NCGC00095256-01
Oprea1_642176
CHEMBL1398476
DTXSID50859126
HMS1662L01
CCG-241375
NCGC00095256-02
Ethyl 6'-methoxycinchonan-9-yl carbonate