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Midazolam

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Identification
Molecular formula
C18H13N5O3
CAS number
59467-70-8
IUPAC name
ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
State
State

Midazolam at room temperature is a solid. It is usually found in its hydrochloride salt form which is more stable for medicinal usage. In this form, it is also soluble in water which makes it suitable for injection purposes.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
362.78g/mol
Molar mass
362.7780g/mol
Density
1.3000g/cm3
Appearence

At room temperature, midazolam appears as a white to yellow crystalline powder. It is generally prepared in its hydrochloride salt form when used in pharmaceutical formulations. The powder is odorless and has a bitter taste. When in solution, it is typically clear and colorless.

Comment on solubility

Solubility of Ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (C18H13N5O3)

The solubility of ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate is an intriguing topic, as it is influenced by multiple factors, including polarity and structure. As a compound with a complex aromatic system, it may exhibit several characteristics:

  • Polarity: Its azido and carboxylate functional groups can impact the overall polarity, potentially increasing solubility in polar solvents.
  • Solvent Interactions: The presence of smaller moieties in the structure (like ethyl) could facilitate solubility in organic solvents, while the larger imidazole and benzodiazepine frameworks might prefer hydrophobic environments.
  • Temperature Dependency: Solubility is often temperature-dependent. Higher temperatures can enhance solubility due to increased molecular motion.
  • pH Influence: The ionization of the carboxylate group may also affect its solubility in aqueous solutions, where changes in pH can lead to variations in solubility behavior.

In general, one could expect that:

  1. **Higher solubility in organic solvents** like ethanol or dimethyl sulfoxide (DMSO).
  2. **Moderate solubility in water**, particularly in buffered solutions that can stabilize the ionized form.

In summary, understanding the solubility of this compound opens up a pathway to explore its potential applications and behavior in different mediums, making it a fascinating subject for further research.

Interesting facts

Interesting Facts about Ethyl 8-Azido-5-Methyl-6-Oxo-4H-Imidazo[1,5-a][1,4]Benzodiazepine-3-Carboxylate

Ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate is a fascinating compound that belongs to the benzodiazepine family. Its unique structure and functional groups introduce both intriguing pharmaceutical potential and various application opportunities in chemical biology. Here are some remarkable aspects of this compound:

  • Potential Therapeutic Use: Compounds within the benzodiazepine class often exhibit properties such as anxiolytic, hypnotic, and anticonvulsant capabilities. The incorporation of an azido group may enhance these effects or provide new properties for therapeutic exploration.
  • Bioorthogonal Chemistry: The azido group is a valuable functional unit in bioorthogonal reactions, allowing for selective labeling and tracking of biomolecules in living systems, which is a key aspect of modern biochemistry.
  • Structural Diversity: The presence of an imidazole ring contributes to the compound's structural diversity, which can lead to variations in biological activity and mechanisms of action compared to other benzodiazepines.
  • Research Potential: Given its intricate structure, ongoing research may reveal novel uses in fields ranging from medicinal chemistry to materials science, making this compound a subject of interest for interdisciplinary collaboration.
  • Pharmacokinetics and Dynamics: Studying how this compound interacts with biological systems can yield insights into absorption, distribution, metabolism, and excretion (ADME) properties, critical for understanding its efficacy and safety.

Overall, ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate exemplifies the rich complexity and potential of chemical compounds. As scientists continue to explore its implications, we may uncover new pathways for innovation in medicine and beyond.

Synonyms
91917-65-6
Ro 15-4513
Ro15-4513
RO-154513
Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
Ro-15-4513
ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
S5XGL82O5Y
Ro 154513
DTXSID80238763
4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
ethyl 12-azido-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate
Ethyl 8-azido-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate
UNII-S5XGL82O5Y
Azidomazenil
ethyl 12-azido-8-methyl-9-oxo-2,4,8-triazatricyclo(8.4.0.0^(2,6))tetradeca-1(10),3,5,11,13-pentaene-5-carboxylate
[3H]Ro154513
CHEMBL6597
GTPL4296
GTPL4365
SCHEMBL15009603
BDBM26267
CHEBI:93452
DTXCID30161254
HMS3268D11
HMS3413A05
HMS3677A05
HMS3752C17
RDA91765
MFCD00078598
PDSP1_001777
PDSP2_001760
AKOS024456901
[3H]Ro15-4513
Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
NCGC00092292-01
Ro15-4513?
4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, (Z,E,E,E,E)-
8-azido-5,6-dihydro-5-methyl-6-oxo-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
DA-77499
MS-24865
RO154513
HY-103476
CS-0027980
G12275
Q7339199
BRD-K82823076-001-01-8
BRD-K82823076-001-02-6
Ethyl8azido5,6dihydro5methyl6oxo4Himidazo1,4benzodiazepine3carboxylate
4HImidazo(1,5a)(1,4)benzodiazepine3carboxylic acid, 8azido5,6dihydro5methyl6oxo, ethyl ester
Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate