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Ethyl 8-fluoro-3-oxo-octanoate

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Identification
Molecular formula
C10H17FO3
CAS number
1030-45-5
IUPAC name
ethyl 8-fluoro-3-oxo-octanoate
State
State

At room temperature, ethyl 8-fluoro-3-oxo-octanoate is usually in the liquid state. It is not volatile and remains stable as a liquid under normal conditions.

Melting point (Celsius)
-50.00
Melting point (Kelvin)
223.15
Boiling point (Celsius)
256.50
Boiling point (Kelvin)
529.65
General information
Molecular weight
204.24g/mol
Molar mass
204.2430g/mol
Density
1.0284g/cm3
Appearence

Ethyl 8-fluoro-3-oxo-octanoate is typically a colorless to pale yellow liquid. It is clear and can have a slightly oily appearance. The compound does not possess any immediate visible particulate matter, assuming it is in pure form.

Comment on solubility

Solubility of Ethyl 8-Fluoro-3-Oxo-Octanoate

Ethyl 8-fluoro-3-oxo-octanoate, with the chemical formula C13H21F1O3, exhibits interesting solubility characteristics influenced by both its functional groups and overall structure.

In Water

This compound is generally considered to have low solubility in water due to:

  • The presence of the hydrophobic octanoate chain, which resists interaction with water.
  • The size and branching of the molecule, which can hinder effective hydrogen bonding with water molecules.

As a result, it might be classified as a poorly soluble compound in aqueous environments.

In Organic Solvents

However, ethyl 8-fluoro-3-oxo-octanoate displays greater solubility in many organic solvents, specifically:

  • Ether
  • Chloroform
  • Ethyl acetate
  • Benzene

This increased solubility can be attributed to the molecule's ability to engage in Van der Waals interactions and dipole-dipole interactions with organic solvent molecules.

Conclusion

In summary, while ethyl 8-fluoro-3-oxo-octanoate is less soluble in water, it finds considerable solubility in organic solvents, making it suitable for various applications in organic chemistry and synthesis.

Interesting facts

Interesting Facts about Ethyl 8-Fluoro-3-oxo-octanoate

Ethyl 8-fluoro-3-oxo-octanoate is a fascinating compound in the realm of organic chemistry, particularly recognized for its diverse applications and unique properties. Here are some compelling facts:

  • Fluorine Influence: The presence of the F atom significantly enhances the chemical and biological characteristics of this compound. Fluorine can affect the compound's reactivity and stability, making it of interest in pharmaceuticals.
  • Versatile Synthesis: Ethyl 8-fluoro-3-oxo-octanoate can be synthesized through various methods, often involving the acylation of ethyl octanoate. This versatility allows chemists to explore different pathways and optimize yield.
  • Biological Applications: The structural framework of this compound suggests potential applications in drug development. Compounds similar to ethyl 8-fluoro-3-oxo-octanoate are studied for their biological activity, including anti-inflammatory and antimicrobial effects.
  • Incorporation in Research: Scientists are investigating this compound and its derivatives for their role in various chemical reactions, particularly as intermediates in the synthesis of more complex molecules.
  • Contribution to Flavor Chemistry: Compounds containing ester groups are often evaluated within the realm of flavor chemistry, contributing to the sensory profiles of various products. The unique attributes of ethyl 8-fluoro-3-oxo-octanoate might offer intriguing flavor characteristics.

As a compound that beautifully bridges different aspects of organic chemistry and applied sciences, ethyl 8-fluoro-3-oxo-octanoate exemplifies how subtle changes in molecular structure can lead to profound implications in both research and industrial applications. It opens the door to exciting developments in chemical synthesis and pharmaceutical research.

Synonyms
Ethyl 8-fluoro-3-oxooctanoate
333-56-2
BRN 1775525
Ethyl omega-fluoro-3-oxooctanoate
8-Fluoro-3-oxo-octanoic acid ethyl ester
OCTANOIC ACID, 8-FLUORO-3-OXO-, ETHYL ESTER
DTXSID30186922
4-03-00-01611 (Beilstein Handbook Reference)
8-Fluoro-3-oxooctanoic acid ethyl ester
SCHEMBL3104038
DTXCID70109413