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Terbinafine

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Identification
Molecular formula
C13H13F3NO2
CAS number
91161-71-6
IUPAC name
ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate
State
State

At room temperature, terbinafine is typically in a solid state as a crystalline powder.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
528.60
Boiling point (Kelvin)
801.80
General information
Molecular weight
311.40g/mol
Molar mass
311.4030g/mol
Density
1.2060g/cm3
Appearence

Terbinafine appears as a white to off-white crystalline powder. It is generally devoid of odor and is known for its solubility in methanol, ethanol, and acetone but is very slightly soluble in water.

Comment on solubility

Solubility of Ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate

The solubility characteristics of ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate can be quite intriguing. This compound, known for its unique structure, offers various insights into its solubility behavior in different solvents.

Key Points of Solubility

  • Polar vs. Non-Polar Solvents: Given the presence of the trifluoromethyl group, which is quite electronegative, and the carbamate functionalities, this compound is expected to exhibit greater solubility in polar solvents such as water and ethanol compared to non-polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds through the carbamate group may enhance its solubility in polar protic solvents.
  • Influence of Fluorine: The electronegative fluorine atoms often affect the compound's overall polarity, potentially making it more soluble in specific organic solvents.

In conclusion, the solubility of ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate is influenced by its unique structure and functional groups, which dictate its compatibility with various solvents. Further studies can provide deeper insights into its solubility dynamics across different environments.

Interesting facts

Interesting Facts about Ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate

Ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate, commonly referred to in the literature as a derivative of carbamate, reveals a fascinating realm of synthetic chemistry that holds various implications in both academic and practical applications.

Key Features:

  • Synthetic Versatility: This compound is synthesized through an elegant method involving various reaction pathways, showcasing the versatility of carbamate functionalities.
  • Potent Bioactivity: Compounds like this one can exhibit substantial *biological activity*, often utilized in the design of pharmaceuticals or agrochemicals.
  • Fluorinated Characteristics: The presence of the trifluoromethyl group not only influences the compound’s *lipophilicity* but also its ability to interact with biological systems, making it a candidate for deeper research into *antimicrobial and anti-inflammatory* properties.

Research Applications:

Due to its unique structure, researchers are particularly interested in this compound for several reasons:

  • It serves as a valuable building block in organic synthesis.
  • The introduction of the trifluoromethyl group has implications in modifying reactivity and stability.
  • Studies suggest that fluorinated compounds may enhance *pharmacokinetic properties*, making them more efficient in biological settings.

Quote by a Chemistry Scholar:

As one researcher noted, “The incorporation of fluorine into organic molecules has revolutionized the way we understand reactivity and stability in medicinal chemistry.”

In summary, ethyl N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]carbamate stands at the crossroads of innovation and application, subsequently offering a wealth of opportunities for scientists to explore its potential further. The amalgamation of its functional groups fosters an exciting area of study for those engrossed in the world of synthetic organic chemistry.

Synonyms
N-(alpha-Methyl-3-trifluoromethylphenethyl)carbamic acid ethyl ester
BRN 2147265
27891-33-4
CARBAMIC ACID, N-(alpha-METHYL-m-TRIFLUOROMETHYLPHENETHYL)-, ETHYL ESTER
Carbamic acid, (1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)-, ethyl ester
RefChem:332671
DTXSID60950572
BAXFKXBEBIPHLF-UHFFFAOYSA-N
Ethyl hydrogen {1-[3-(trifluoromethyl)phenyl]propan-2-yl}carbonimidate