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Carbamazepine

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Identification
Molecular formula
C15H12N2O
CAS number
298-46-4
IUPAC name
ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate
State
State

At room temperature, carbamazepine is in a solid state. It takes the form of a crystalline powder that remains stable under standard conditions.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
607.00
Boiling point (Kelvin)
880.15
General information
Molecular weight
236.27g/mol
Molar mass
236.2680g/mol
Density
1.2900g/cm3
Appearence

Carbamazepine appears as a white or off-white crystalline powder. It is noted for its slightly bitter taste and lack of odor. The compound is not very soluble in water but is soluble in numerous organic solvents, such as ethanol and propylene glycol.

Comment on solubility

Solubility of Ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate

The solubility of ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate is influenced by various factors, most notably its chemical structure and functional groups. This compound contains both hydrophobic and hydrophilic characteristics, leading to intricate solubility behavior:

  • Solvent Type: The solubility is generally better in polar solvents, such as water and alcohols, due to its potential ability to form hydrogen bonds.
  • Temperature Dependency: Increased temperature often enhances solubility for many organic compounds, including ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate.
  • pH Influence: The solubility can be affected by the pH of the solution, which could alter the ionization of functional groups within the molecule.
  • Concentration Effects: High concentrations may lead to reduced solubility, as the solute may exceed its solubility limit, resulting in precipitation.

As a general observation, compounds like ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate often exhibit:

  1. Higher solubility in organic solvents compared to aqueous solutions.
  2. Temperature-dependent behavior, where elevated temperatures typically promote better solubility.

Understanding the solubility of this compound is essential, particularly for pharmaceutical applications, where the availability of the drug can significantly impact its effectiveness in therapeutic settings. Proper solubility assessment is a critical step in formulation development and can dictate the success of the compound's application.

Interesting facts

Interesting Facts about Ethyl N-[10-(3-Morpholinopropanoyl)phenothiazin-2-yl]carbamate

Ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate is a fascinating compound that has garnered interest in the field of medicinal chemistry. Here are some intriguing details about this compound:

  • Pharmaceutical Relevance: It belongs to the class of phenothiazine derivatives, which are known for their diverse pharmacological properties, especially in antipsychotic and antiemetic treatments.
  • Molecular Complexity: The presence of the morpholine group adds to the molecular complexity of this compound, potentially influencing its interactions at the receptor level.
  • Action Mechanism: Compounds in this class often exhibit their effects by blocking dopamine receptors in the brain, which is essential for their therapeutic effects.
  • Hybrid Structure: The combination of phenothiazine and morpholine moieties in its structure signifies a strategic design aiming to enhance efficacy while minimizing side effects.
  • Versatile Applications: Beyond psychiatric treatments, there is research exploring the potential uses of this compound in tackling other conditions, such as certain types of cancer and infections.

As a scientist or chemistry student, it's exciting to delve into the nuances of such compounds. As the great chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." With compounds like ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate, one can certainly explore numerous avenues in drug discovery and development!

Synonyms
MORICIZINE
Moracizine
31883-05-3
Moracizina
Moracizinum
Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate
2GT1D0TMX1
EN-313 FREE BASE
CHEBI:6997
ethyl N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate
Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester
DTXSID4023335
Moracizin
ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate
CARBAMIC ACID, [10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-, ETHYL ESTER
[10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester
ethyl N-(10-(3-(morpholin-4-yl)propanoyl)-10H-phenothiazin-2-yl)carbamate
(10-(3-Morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl)-carbamic acid ethyl ester
N-(10-(3-(morpholin-4-yl)propanoyl)-10H-phenothiazin-2-yl)ethoxycarboximidic acid
N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}ethoxycarboximidic acid
RefChem:819399
DTXCID803335
C01BG01
EN313
250-854-5
Moricizine [USAN]
Moracizinum [INN-Latin]
Moracizina [INN-Spanish]
EN-313
C22H25N3O4S
ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
Moracizine (INN)
Moracizine [INN]
Moricizine (USAN)
EN 313
ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate
Ethyl (10-(3-morpholinopropanoyl)-10H-phenothiazin-2-yl)carbamate
G 214
NCGC00016809-01
NCGC00016809-07
EINECS 250-854-5
UNII-2GT1D0TMX1
Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester
Ethyl (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamate
MFCD00336543
MORICIZINE [MI]
Prestwick0_001051
Prestwick1_001051
Prestwick2_001051
Prestwick3_001051
MORICIZINE [VANDF]
MORACIZINE [MART.]
TimTec1_000772
CHEMBL1075
MORACIZINE [WHO-DD]
Oprea1_682904
Oprea1_701257
SCHEMBL16794
BSPBio_001002
CBDivE_008814
MLS001201823
BIDD:GT0499
SPBio_002931
BPBio1_001104
GTPL7244
orb1706953
SCHEMBL29599149
HMS1536D02
HMS2852B19
BCP14374
ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate
HY-B0615
STK370502
AKOS001487682
ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate
DB00680
Carbamic acid,[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-,ethyl ester
NCGC00016809-02
NCGC00016809-03
NCGC00016809-04
NCGC00074074-03
SMR000059585
ST012322
CAS-31883-05-3
DB-048124
AB00514710
NS00029189
C07743
D05077
AB00514710-13
883M053
EN300-18530976
Q904071
BRD-K21548250-003-03-5
BRD-K21548250-003-19-1
Ethyl 10-(beta-Morpholinopropionyl)phenothiazine-2-carbamate
[10-[3-(4-morpholinyl)-1-oxopropyl]-10h-phenothiazin-2-yl]-, ethyl ester
ethoxy-N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carboxamide