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Ethyl carbamate phenothiazine hydrochloride

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Identification
Molecular formula
C22H24ClN3O4S
IUPAC name
ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate;hydrochloride
State
State

This compound is typically in a solid state at room temperature. It is stable under normal conditions of use and storage. It may exist in the form of a crystalline powder.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
345.00
Boiling point (Kelvin)
618.15
General information
Molecular weight
456.98g/mol
Molar mass
456.9750g/mol
Density
1.3200g/cm3
Appearence

Ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate;hydrochloride typically appears as an off-white or pale yellow solid powder. Its appearance may be slightly crystalline depending on the conditions such as purity and method of preparation.

Comment on solubility

Solubility of Ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate; hydrochloride

The solubility of ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate; hydrochloride is an important consideration in its application and effectiveness. Here are some key points regarding its solubility:

  • Water Solubility: As a hydrochloride salt, this compound is likely to have improved solubility in water compared to its parent base form. Hydrochloride salts generally enhance the solubility of organic compounds due to the presence of charged species.
  • Organic Solvents: The solubility in organic solvents such as ethanol, methanol, or DMSO may also be significant due to the presence of hydrophobic phenothiazine moiety and the morpholino group.
  • pH Sensitivity: The solubility can be affected by the pH of the solution. For instance, increasing acidity may enhance solubility due to the protonation of basic groups within the structure.
  • Temperature Dependency: Like many compounds, solubility may increase with higher temperatures, which may facilitate its dissolution in various solvents.
  • Crystallization: The salt form might also exhibit distinct crystallization behavior, which can influence its solubility characteristics.

Overall, the solubility trait of ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate; hydrochloride is crucial in determining its bioavailability and therapeutic efficacy. Understanding its solubility profile can significantly impact formulation strategies.

Interesting facts

Interesting Facts about Ethyl N-[10-(3-Morpholinopropanoyl)phenothiazin-2-yl]carbamate Hydrochloride

Ethyl N-[10-(3-Morpholinopropanoyl)phenothiazin-2-yl]carbamate hydrochloride is a fascinating compound primarily explored for its potential therapeutic applications. Here are some notable insights:

  • Pharmaceutical Relevance: This compound is related to the class of drugs known as phenothiazines, which are widely used as antipsychotic and antiemetic agents. Their structure allows them to interact effectively with neurotransmitter pathways in the brain, particularly influencing dopamine receptors.
  • Morpholine Moiety: The presence of a morpholine group in the structure contributes significantly to its pharmacological properties. Morpholine derivatives have been known to exhibit various biological activities, including antimicrobial and anti-inflammatory effects.
  • Targeted Therapeutics: The design of this compound suggests that it may be useful in targeted therapies. The unique phenothiazine core combined with a propanoyl morpholine group opens avenues for research into specific receptor interactions, potentially enhancing therapeutic efficacy while minimizing side effects.
  • Synthetic Interest: The synthesis of such compounds presents an interesting challenge for chemists. Understanding the reaction pathways and optimizing yields is crucial for pharmaceutical applications, making it a significant topic of study in organic chemistry.
  • Research Potential: Ongoing studies investigate the compound's mechanism of action and its effects on various types of mental health disorders. This research could lead to the development of novel treatments that are more effective and have fewer adverse reactions.

In summary, ethyl N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamate hydrochloride offers a rich landscape for exploration in pharmaceutical chemistry, blending the therapeutic potential of phenothiazines with innovative structural modifications. As pharmaceutical science continues to evolve, compounds like this one underpin the advancement of new treatment strategies.

Synonyms
MORICIZINE HYDROCHLORIDE
29560-58-5
Moracizine hydrochloride
Ethmozine
Moricizine HCl
Ethmozin
Etmozin
71OK3Z1ESP
DTXSID1047786
Moricizine hydrochloride (USP)
Moricizine hydrochloride [USP]
DTXCID1027766
CHEBI:60937
Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate hydrochloride
Ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate hydrochloride
RefChem:56790
Hydrochloride, Moricizine
Carbamic Acid,(10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, Ethyl Ester, Monohydrochloride
Ethmosine
Moricizine (Hydrochloride)
ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydrochloride
MLS000830274
EN 313; Ethmosine; Ethmozin
EN 313
moracizine HCl
SMR000036736
Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate, hydrochloride
Carbamic acid, (10-(3-(4-morpholinyl)-l-oxopropyl)-10H-phenothiazin-2yl)-, ethyl ester, hydrochloride
CAS-29560-58-5
NCGC00016809-01
NCGC00016809-07
UNII-71OK3Z1ESP
Ethmozine (TN)
Opera_ID_267
Cambridge id 5229972
Ethyl ether of 10-(beta-morpholylpropionyl)phenthiazinecarbamino acid hydrochloride
SCHEMBL41358
SCHEMBL41359
(10-(3-(4-Morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamic acid, ethyl ester, monohydrochloride
MLS000080120
REGID_for_CID_34632
orb1687100
CHEMBL1200334
HY-B0615A
HMS1571C04
Tox21_110622
MORICIZINE HYDROCHLORIDE [MI]
AKOS030506898
Tox21_110622_1
CCG-221051
MORACIZINE HYDROCHLORIDE [MART.]
MORICIZINE HYDROCHLORIDE [VANDF]
Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester, hydrochloride
MORACIZINE HYDROCHLORIDE [WHO-DD]
MORICIZINE HYDROCHLORIDE [USP-RS]
NCGC00180924-01
Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester, monohydrochloride
DB-047605
CS-0013699
E-313
E-350
MORICIZINE HYDROCHLORIDE [ORANGE BOOK]
D02087
MORICIZINE HYDROCHLORIDE [USP IMPURITY]
SR-01000614327
SR-01000614327-4
Q27130132
ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;hydron;chloride
Carbamic acid, N-(10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester, hydrochloride (1:1)