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Ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate

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Identification
Molecular formula
C18H17N3O3
CAS number
144282-55-7
IUPAC name
ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate
State
State

At room temperature, ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate exists in a solid state. Like many aromatic carbamates, it displays stability and low volatility in this form.

Melting point (Celsius)
213.50
Melting point (Kelvin)
486.65
Boiling point (Celsius)
605.40
Boiling point (Kelvin)
878.55
General information
Molecular weight
350.37g/mol
Molar mass
350.3710g/mol
Density
1.2800g/cm3
Appearence

Ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate typically appears as a crystalline solid. This compound can have various hues, often depending on the purity and specific conditions of isolation or synthesis.

Comment on solubility

Solubility of Ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate

The solubility of ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate can exhibit some interesting characteristics due to its structural complexity. As with many organic compounds, the solubility in various solvents can vary significantly:

  • Polar solvents: Compounds like water and methanol tend to solvate polar functional groups effectively. Depending on the presence of polar or ionizable groups in ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate, its solubility in polar solvents may be higher.
  • Non-polar solvents: In contrast, non-polar solvents such as hexane or toluene may show reduced solubility due to the hydrophobic parts of the molecular structure dominating interactions.
  • Temperature effects: The solubility of this compound may increase with temperature, as higher temperatures often allow compounds to dissolve more readily due to increased molecular motion.

Moreover, it is essential to note that the pH of the solvent can also influence the solubility by affecting the ionization of functional groups present in the compound:

  • In acidic conditions, the protonation of basic sites may occur, potentially enhancing solubility.
  • In alkaline conditions, deprotonation can facilitate solubility as well.

In summary, the solubility of ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate is dependent on a variety of factors including solvent polarity, temperature, and pH. Always consider performing solubility tests in various conditions to obtain accurate data!

Interesting facts

Interesting Facts about Ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate

Ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate is a fascinating compound that has garnered interest in the realm of medicinal chemistry. Below are some intriguing aspects of this compound:

  • Pharmacological Potential: This compound falls within a class known for potential therapeutic applications, particularly in the field of anti-cancer and anti-inflammatory drug development. Its structure suggests it could interact with cellular pathways involved in these diseases.
  • Quinazoline Derivative: Quinazoline, a moiety present in this compound, has a rich history in medicinal chemistry. Compounds containing quinazoline often exhibit a variety of biological activities including antimicrobial, anti-inflammatory, and anti-cancer effects.
  • Structure-Activity Relationship (SAR): Understanding how changes in molecular structure impact the biological activity of compounds like ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate is essential. This can lead to design strategies for more potent drugs.
  • Research Interest: Recent studies have focused on the pharmacodynamics and pharmacokinetics of compounds like this, looking to uncover how they can be effectively utilized in therapeutic settings. The research is promising and continues to grow.
  • Industrial Applications: Beyond pharmaceuticals, compounds with similar structures could find applications in agrochemicals or as biocides, showcasing the versatility of this chemical family.

In conclusion, ethyl N-[2-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]carbamate exemplifies the intricate link between chemical structure and biological activity. As research progresses, we might see this compound playing a vital role in future therapeutic developments.