Skip to main content

Thiotepa

ADVERTISEMENT
Identification
Molecular formula
C6H12N3O2P
CAS number
52-24-4
IUPAC name
ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate
State
State

Thiotepa is a solid at room temperature, usually available as a crystalline powder.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
348.42g/mol
Molar mass
189.2010g/mol
Density
1.1400g/cm3
Appearence

Thiotepa appears as a colorless crystalline powder with a slight odor. It is typically very stable and sensitive to moisture upon exposure in air.

Comment on solubility

Solubility of Ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate

The solubility of ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate is a fascinating topic to consider, particularly due to its unique structural characteristics. This compound is characterized by its dual aziridine units, which can influence its interaction with solvents. Here are some key points regarding its solubility:

  • Polarity: The presence of phosphoryl and carbamate groups generally increases polarity, making the compound more soluble in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in water, as such interactions facilitate the dissolution process.
  • Solvent Compatibility: Ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate may demonstrate varying solubility in different organic solvents such as ethanol, methanol, or acetonitrile, depending on their polarity.
  • Temperature Effects: As with many compounds, solubility can be affected by temperature; typically, solubility increases with temperature.

In conclusion, while specific solubility data for ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate may be limited, its structure suggests a potential for good solubility in polar solvents, making it a compound of interest in various chemical applications.

Interesting facts

Interesting Facts about Ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate

Ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate is a fascinating compound that combines elements of organic chemistry with significant application potential. Here are some key insights:

  • Structure and Functionality: This compound features a complex structure that includes aziridine rings. The presence of these rings can influence its reactivity and potential interactions in biological systems.
  • Phosphoryl Group: The phosphoryl (PO4) group is noteworthy due to its role in biochemistry, particularly in energy transfer and storage, as seen in compounds like ATP.
  • Carbamate Moiety: The carbamate part of the molecule is often associated with insecticide and herbicide activity, making this compound of interest in agrochemical research.
  • Potential Applications: Given its unique structure, there is interest in exploring this compound for uses in:
    • Pesticide development
    • Medicinal chemistry
    • Material science for polymer synthesis
  • Importance of Aziridine: The aziridine rings impart significant strain and reactivity, making this compound a candidate for further study in cycloaddition reactions and other synthetic applications.

Overall, ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate serves as an excellent example of the intricate relationships between structure, reactivity, and potential application in multiple fields of chemistry. As research continues in this area, compounds like this may pave the way for innovations in both agricultural and medicinal chemistry!

Synonyms
METUREDEPA
1661-29-6
Turloc
Dimethylurethimine
AB 132
AB-132
ethyl N-bis(2,2-dimethylaziridin-1-yl)phosphorylcarbamate
Bis(2,2-dimethylaziridinyl)phosphinylurethane
NSC-51325
NSC51325
Ethyl [bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamate
43255365IF
(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)carbamic acid, ethyl ester
Ethyl (bis(2,2-dimethyl-1-aziridinyl)phosphinyl)carbamate
Ethyl N-(bis(2,2-dimethylethylenimido)phosphoro)carbamate
Ethyl N-[bis(2,2-dimethylethylenimido)phosphoro]carbamate
Meturedepum
Carbamic acid, (bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-, ethyl ester
Carbamic acid, [bis(2,2-dimethyl-1-aziridinyl)phosphinyl]-, ethyl ester
Meturedepa [USAN:INN]
Meturedepum [INN-Latin]
[Bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamic acid, ethyl ester
UNII-43255365IF
NSC 51325
METUREDEPA [MI]
AI3-50452
METUREDEPA [INN]
Meturedepa (USAN/INN)
METUREDEPA [USAN]
SCHEMBL11711
CHEMBL280685
DTXSID60862727
CHEBI:135138
AKOS040748911
HY-117980
CS-0068775
NS00124803
D05018
Q27258602
Ethyl bis(2,2-dimethyl-1-aziridinyl)phosphorylcarbamate
Ethyl [bis(2,2-dimethylaziridin-1-yl)phosphoryl]carbamate
[Bis(2,2-dimethyl-1-aziridinyl)phosphinyl]carbamic acid ethyl ester
Carbamic acid,2-dimethyl-1-aziridinyl)-phosphinyl]-, ethyl ester
Carbamic acid, [bis(2,2-dimethyl-1-aziridinyl)-phosphinyl]-, ethyl ester