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Thiotepa

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Identification
Molecular formula
C6H12N3OPS
CAS number
52-24-4
IUPAC name
ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate
State
State

At room temperature, Thiotepa is in a solid state, appearing as a white crystalline powder.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
228.00
Boiling point (Kelvin)
501.15
General information
Molecular weight
189.20g/mol
Molar mass
189.1980g/mol
Density
1.1900g/cm3
Appearence

Thiotepa appears as a white crystalline solid. It is typically odorless and may have a slightly bitter taste. This solid form is stable under recommended storage conditions and is usually presented as powder for pharmaceutical use.

Comment on solubility

Solubility of Ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate

Ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate is a fascinating compound with unique solubility characteristics. Understanding its solubility can be crucial for applications in biochemical processes and synthesis. Here are some key points regarding its solubility:

  • Solvent Specificity: This compound may exhibit variable solubility depending on the solvent due to its distinct functional groups.
  • Apolar vs Polar Solvents: It is likely to be more soluble in polar solvents because of its polar phosphoryl group, facilitating dissolution.
  • Temperature Influence: Like many chemical compounds, solubility is often affected by temperature. Higher temperatures may increase solubility.
  • pH Dependency: The solubility could be influenced by the pH of the solution, as protonation of the amino groups can enhance solubility.

Moreover, the presence of aziridine rings suggests that solubility might also be impacted by steric effects and intermolecular interactions such as hydrogen bonding. Understanding these factors is essential for optimizing conditions in synthetic and pharmacological applications.

In conclusion, while specific solubility data for ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate may be limited, exploring its solubility profile can lead to valuable insights in its practical uses and effectiveness.

Interesting facts

Interesting Facts about Ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate

Ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate is a fascinating compound that draws significant interest in the field of chemical science due to its unique structural characteristics and potential applications. Below are some intriguing points regarding this compound:

  • Unique Composition: This compound features a phosphoric acid derivative that incorporates aziridine rings, which are three-membered cyclic amines. The presence of aziridine units can impart interesting reactivity and the potential for polymerization.
  • Biological Relevance: Compounds that contain aziridine rings often show promising biological activities, including antitumor and antibacterial properties. Researchers are continually exploring their efficacy in drug development.
  • Synthetic Utility: The versatile nature of aziridines allows chemists to use them as intermediate reagents. This makes the compound valuable for synthetically building more complex structures, including pharmaceuticals and agrochemicals.
  • Potential Applications: The functionalities present in ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate may lead to applications in areas such as:
    • Medicinal chemistry
    • Organic synthesis
    • Pesticide formulation
  • Research Interest: Due to the compound's intriguing scaffold, it has garnered attention in academic circles, prompting a plethora of studies focused on its properties, reactivity, and potential applications.

As a compound on the cutting edge of both organic chemistry and medicinal research, ethyl N-[bis(aziridin-1-yl)phosphoryl]ethanimidate exemplifies how structure can lead to varied functionalities and applications. Its interplay between aziridine and phosphorous chemistry continues to open new avenues for exploration in the chemical sciences.