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Ethyl 1-piperidinecarboxylate

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Identification
Molecular formula
C8H15NO2
CAS number
529-17-9
IUPAC name
ethyl piperidine-1-carboxylate
State
State

This compound is a liquid at room temperature.

Melting point (Celsius)
-40.00
Melting point (Kelvin)
233.15
Boiling point (Celsius)
188.00
Boiling point (Kelvin)
461.15
General information
Molecular weight
157.21g/mol
Molar mass
157.2140g/mol
Density
0.9830g/cm3
Appearence

Ethyl 1-piperidinecarboxylate appears as a colorless to pale yellow liquid. It may have a faint odor characteristic of amine or ester functional groups.

Comment on solubility

Solubility of Ethyl Piperidine-1-Carboxylate

Ethyl piperidine-1-carboxylate, a compound with the formula C9H15NO2, exhibits intriguing solubility characteristics. Understanding its solubility is essential for applications in various fields, including pharmaceuticals and synthetic chemistry. Here’s a closer look at its solubility:

  • Polar Nature: The presence of the carboxylate group contributes to the polar nature of the compound, enhancing its potential for solubility in polar solvents like water.
  • Solvent Compatibility: Ethyl piperidine-1-carboxylate is likely more soluble in organic solvents such as ethanol, methanol, and chloroform, due to its ethyl group that enhances interactions with similar non-polar environments.
  • Temperature Dependence: Like many organic compounds, solubility may vary with temperature; generally, higher temperatures can improve solubility in organic solvents.
  • Impurities Effect: The presence of impurities or other solutes might affect the solubility dynamics, causing potential variations in practical applications.

In summary, while ethyl piperidine-1-carboxylate demonstrates the capacity for solubility in both polar and non-polar solvents, its practical utility often depends on careful consideration of solvent attributes and conditions. Thus, experimenting with different solvents and conditions can yield valuable insights into its solubility behavior.

Interesting facts

Interesting Facts about Ethyl Piperidine-1-Carboxylate

Ethyl piperidine-1-carboxylate is a fascinating compound that falls under the category of piperidine derivatives, often explored in the field of organic chemistry for its unique properties and applications. Here are some intriguing aspects of this compound:

  • Reactivity: The ethyl piperidine-1-carboxylate molecule contains both ester and amine functional groups, which make it highly reactive. This reactivity opens the door for various chemical reactions, including nucleophilic substitutions and formation of more complex compounds.
  • Synthetic Applications: It plays a crucial role in the synthesis of pharmaceuticals and agrochemicals. The piperidine ring is a common motif in many bioactive compounds, making this derivative important for drug discovery and development.
  • Flexibility in Modifications: Due to the presence of the ethyl group and the piperidine structure, this compound can be modified to create a wide array of derivatives. Such modifications can lead to enhanced biological activity or altered physical properties.
  • Significance in Medicinal Chemistry: Research indicates that piperidine derivatives can exhibit varied pharmacological properties, including anti-inflammatory, analgesic, and antitumor activities. The ethyl piperidine-1-carboxylate structure serves as a scaffold for designing new medicinal agents.
  • Research Frontiers: Ongoing studies focus on the optimization of this compound for better efficacy and safety profiles in therapeutic contexts. “The exploration of piperidine derivatives opens endless possibilities in medicinal chemistry,” mentions a well-known researcher in the field.

In conclusion, ethyl piperidine-1-carboxylate embodies the essence of how simple structural modifications in organic compounds can lead to significant advancements in science and medicine.

Synonyms
ethyl piperidine-1-carboxylate
Ethyl 1-piperidinecarboxylate
1-PIPERIDINECARBOXYLIC ACID, ETHYL ESTER
NSC 236
NSC 100911
BRN 0118408
DTXSID90201362
5-20-02-00480 (Beilstein Handbook Reference)
DTXCID90123853
625-971-3
inchi=1/c8h15no2/c1-2-11-8(10)9-6-4-3-5-7-9/h2-7h2,1h
yspvhaujxlgzhp-uhfffaoysa-n
5325-94-0
N-Carbethoxypiperidine
Pentamethylene urethane
ethyl piperidinecarboxylate
MFCD00047470
WLN: T6NTJ AVO2
piperidine-1-carboxylic acid ethyl ester
N-ethoxycarbonylpiperidine
1-ethoxycarbonyl-piperidine
NCIOpen2_001719
SCHEMBL675456
NSC236
NSC-236
ethyl-1-PIPERIDINECARBOXYLATE
Ethyl 1-piperidinecarboxylate, 97%
NSC100911
piperidine carboxylic acid ethyl ester
piperidinecarboxylic acid, ethyl ester
AKOS003846724
CS-W017967
NSC-100911
SB41371
DS-16911
SY107338
DB-052281