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Tafenoquine

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Identification
Molecular formula
C24H28N2O5
CAS number
106635-80-7
IUPAC name
ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] carbonate
State
State

At room temperature, Tafenoquine is typically found in a solid state. Being a medicinal compound, it might be processed and stored in this form for pharmaceutical manufacturing and formulation into tablets or capsules, which are then distributed for therapeutic use.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
463.57g/mol
Molar mass
463.5650g/mol
Density
1.3300g/cm3
Appearence

Tafenoquine, the compound with the given IUPAC name, typically appears as a white to off-white powder. It is a synthetic quinoline derivative used primarily for its antimalarial properties. The powder may have a slight yellow tinge depending on its purity and processing, but is generally uniform in its texture and color.

Comment on solubility

Solubility of Ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] Carbonate

The solubility of ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] carbonate presents an intriguing profile. Understanding the solubility of such a compound is essential as it can significantly influence its effectiveness and application in various contexts.

Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The polarity of molecules plays a crucial role in determining how well they dissolve in various solvents. Ethyl carbonate groups tend to be polar, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The presence of functional groups capable of hydrogen bonding can also increase solubility in specific solvents, particularly in alcohols and some ethers.
  • Molecular Interactions: The unique structure of this compound may foster interactions with solvent molecules, either stabilizing the solute or leading to aggregative behavior that affects solubility.

Solvent Compatibility

In general, for this type of compound, one might find:

  • High solubility in polar organic solvents such as ethanol or acetone.
  • Limited solubility in non-polar solvents due to its complex structure.
  • Possible insolubility in water, influenced by the hydrophobic regions present in its composition.

As a result, understanding the solubility properties is vital for predicting the behavior of ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] carbonate in practical applications, particularly in pharmaceutical contexts where solubility directly impacts bioavailability and therapeutic efficacy. Always remember, "like dissolves like."

Interesting facts

Interesting Facts about Ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] Carbonate

Ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] carbonate, often referred to in scientific literature by its more complex structure, presents a fascinating compound for exploration within the realm of medicinal chemistry.

Highlights and Applications

  • Pharmaceutical Potential: This compound is part of a class of molecules known for their biological activity, particularly in neuropharmacology. It is of interest in the development of treatments for various neurological disorders.
  • Unique Structural Features: The presence of both a quinoline structure and a quinuclidine system within its molecular architecture introduces distinct stereochemical characteristics that can influence the compound's interaction with biological targets.
  • Research Relevance: Many studies focus on similar compounds to understand their mechanisms of action, with potential implications in drug design and medicinal efficacy.

Scientific Exploration

Researchers are intrigued by the ability of compounds like this to modulate biological pathways, as indicated by several studies that explore:

  • Antioxidant properties which can help protect cells from oxidative stress.
  • Allosteric modulation of neurotransmitter receptors, thereby influencing synaptic transmission.
  • Pharmacokinetic profiles that can inform dosing regimens in clinical applications.

As we delve deeper into the world of complex organic molecules, the need for understanding the interplay between structure and function becomes increasingly vital. This compound embodies the intricate balance of chemical design and therapeutic potential, drawing attention from both chemists and pharmacologists alike.

In summary, ethyl [(R)-(6-methoxy-4-quinolyl)-[(2S,4R,5R)-5-vinylquinuclidin-2-yl]methyl] carbonate is not just a compound to study but a stepping stone to significant scientific advances in the fields of chemistry and medicine. Its evolution continues to inspire curiosity and innovation.

Synonyms
CHEBI:177568
AKOS026749909
[(R)-[(2S,4R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] ethyl carbonate
NS00001840
Ethyl (4beta,8alpha,9R)-6'-methoxycinchonan-9-yl carbonate