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Coumarin

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Identification
Molecular formula
C9H6O2
CAS number
91-64-5
IUPAC name
furo[2,3-h]chromen-2-one
State
State
Coumarin is a solid at room temperature, typically occurring in crystalline form.
Melting point (Celsius)
70.00
Melting point (Kelvin)
343.15
Boiling point (Celsius)
301.00
Boiling point (Kelvin)
574.15
General information
Molecular weight
146.14g/mol
Molar mass
146.1410g/mol
Density
0.9354g/cm3
Appearence

Coumarin is a crystalline solid with a strong, sweet odor reminiscent of vanilla and almonds. It appears white to light beige in color. This compound is often found in its crystalline form when pure.

Comment on solubility

Solubility of Furo[2,3-h]chromen-2-one

The solubility of furo[2,3-h]chromen-2-one is a fascinating topic worth exploring. This compound, known for its unique structure, exhibits specific solubility characteristics:

  • Polar Solvents: Generally, furo[2,3-h]chromen-2-one displays increased solubility in polar solvents such as methanol and ethanol. These solvents help to stabilize the molecular structure, facilitating better dissolution.
  • Non-Polar Solvents: Conversely, the solubility tends to decrease significantly in non-polar solvents like hexane. This is often attributed to the compound’s aromatic and heterocyclic features, which favor interactions with more polar environments.
  • Temperature Relation: Interestingly, increased temperatures can improve solubility in certain solvents, allowing more of the compound to dissolve.
  • pH Influence: The pH of the solution can also play a role in solubility behavior, particularly if any ionizable or functional groups are present on the molecule.

In summary, the solubility of furo[2,3-h]chromen-2-one can be influenced by various factors, highlighting the importance of selecting appropriate solvents and conditions for effective dissolution. This versatility makes it an intriguing subject for further study in chemical applications.

Interesting facts

Furo[2,3-h]chromen-2-one: An Intriguing Compound

Furo[2,3-h]chromen-2-one, a fascinating organic compound, belongs to the class of molecules known as chromones. This compound type is particularly interesting due to its diverse biological activities and their potential applications in medicinal chemistry.

Unique Properties and Applications

  • Natural Sources: Furo[2,3-h]chromen-2-one can be found in various plants, illustrating nature's ingenuity in producing compounds with intriguing structures and pharmacological properties.
  • Pharmacological Potential: This compound has drawn attention for its biological activities, including antifungal, antibacterial, and antioxidant properties. Researchers are actively studying these effects for potential therapeutic applications.
  • Chemical Structure: The unique furan and chromene moieties in its structure contribute to its reactivity and the versatility of synthesis, making it a valuable compound in organic synthesis.
  • Mechanistic Studies: Understanding how furo[2,3-h]chromen-2-one interacts with biological systems can shed light on new drug development pathways.

Cultural and Historical Significance

This compound has not only piqued scientific interest but also cultural relevance. Compounds like furo[2,3-h]chromen-2-one serve as essential lead compounds in natural product chemistry, leading to the discovery of novel drugs and treatments. As one researcher noted, “The journey from nature to the lab is where the magic of discovery and innovation truly happens.”

In summary, furo[2,3-h]chromen-2-one exemplifies the beauty of chemistry through its complex structure, natural occurrence, and promising biological activities. As more research unfolds, this compound may hold the key to new scientific advancements and medical breakthroughs.

Synonyms
Angelicin
523-50-2
ISOPSORALEN
2H-Furo[2,3-H]chromen-2-one
Angecin
Furo(2,3-h)coumarin
2H-Furo[2,3-H]-1-benzopyran-2-one
Angelicin (coumarin derivative)
Angelicin (coumarin deriv)
CCRIS 4276
Furo(5',4':7,8)coumarin
NSC 404563
2H-Furo(2,3-H)-1-benzopyran-2-one
HSDB 3554
UNII-CZZ080D7BD
CZZ080D7BD
4-Hydroxy-5-benzofuranacrylic acid gamma-lactone
BRN 0153970
CHEBI:28928
3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone
NSC-404563
2H-Furo(2,3-h)(1)benzopyran-2-one
Furo[5',4':7,8]coumarin
2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, delta-lactone
DTXSID00200321
5-19-04-00447 (Beilstein Handbook Reference)
Furo[2,3-h]coumarin
2H-furo(2,3-h)chromen-2-one
DTXCID00122812
furo[2,3-h]chromen-2-one
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
Isopsoralin
Angelecin
Angelicin (Isopsoralen)
MFCD00064930
CHEMBL53569
Angelicin (Standard)
Furo[5',8]coumarin
ISOPSORALEN [HSDB]
Oprea1_022970
SCHEMBL376379
Furo(5',4',7,8)coumarin
Furo[2,3-h]benzopyran-2-one
NIOSH/LV0940100
HY-N0763R
pyrano[6,5-e]benzofuran-2-one
XDROKJSWHURZGO-UHFFFAOYSA-N
HMS1645D18
BCP29934
HY-N0763
2H-Furo[2,3-H]chromen-2-one #
BDBM50331545
NSC404563
s3892
STL564561
AKOS006281380
Angelicin plus ultraviolet A radiation
CCG-266471
CS-3754
FA17920
Furo[2,3-h]chromen-2-one(angelicin)
NCGC00388372-01
AC-33978
AS-35334
A2573
LV09401000
NS00094600
C09060
EN300-6730963
AA-504/20833001
AA-504/21027016
4-Hydroxy-5-benzofuranacrylic acid .gamma.-lactone
Q2849857
Isopsoralen pound>>2-Oxo-(2H)-furo(2,3-h)-1-benzopyran
3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid .gamma.-lactone
2-Propenoic acid, 3-(4-hydroxy-5-benzofuranyl)-, .delta.-lactone
2H-Furo(2,3-h)(1)benzopyran-2-one, plus ultraviolet A radiation
Furo[2,3-h]chromen-2-one;2-Oxo-(2H)-furo(2,3-H)-1-benzopyran;Isopsoralen
InChI=1/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6