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Imidazo[1,2-a]quinoxaline

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Identification
Molecular formula
C10H7N3
CAS number
253-88-9
IUPAC name
imidazo[1,2-a]quinoxaline
State
State

At room temperature, imidazo[1,2-a]quinoxaline is typically in a solid state. Its stability and structure make it ideal for storage and usage in research labs and pharmaceutical formulations.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.15
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.15
General information
Molecular weight
168.19g/mol
Molar mass
168.1910g/mol
Density
1.3100g/cm3
Appearence

Imidazo[1,2-a]quinoxaline is typically a pale yellow or off-white solid. It appears as a crystalline powder and is known for its use as a core structure in the synthesis of various pharmaceutical compounds. Its color and form may vary slightly depending on purity and specific derivation processes.

Comment on solubility

Solubility of Imidazo[1,2-a]quinoxaline

Imidazo[1,2-a]quinoxaline, a fused heterocyclic compound, presents intriguing characteristics when it comes to its solubility properties. Understanding the solubility of this compound is essential, as it plays a crucial role in various chemical and biological applications.

In general, the solubility of imidazo[1,2-a]quinoxaline can be summarized as follows:

  • Solvent Compatibility: This compound is known to be soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).
  • Water Solubility: Imidazo[1,2-a]quinoxaline exhibits limited solubility in water, which suggests that it is primarily hydrophobic in nature.
  • Influence of Substituents: The solubility can vary significantly depending on the incorporation of various substituents on the imidazo and quinoxaline rings, which can either enhance or reduce solubility.

As stated, “Like dissolves like,” and thus, the molecular structure implies that it prefers to dissolve in similar polar environments rather than in aqueous medium. This solubility behavior is fundamental in applications such as drug formulation, where solubility influences bioavailability.

In conclusion, while imidazo[1,2-a]quinoxaline shows promising solubility in certain solvents, challenges in water solubility highlight the importance of considering solvent choice in its practical usage.

Interesting facts

Interesting Facts about Imidazo[1,2-a]quinoxaline

Imidazo[1,2-a]quinoxaline is an intriguing heterocyclic compound that has garnered attention in the field of medicinal chemistry and organic synthesis. Here are some fascinating insights into this compound:

  • Structure and Chemistry: Imidazo[1,2-a]quinoxaline is characterized by a bicyclic framework, which includes an imidazole and quinoxaline moiety. This unique structure imparts distinctive chemical properties and reactivity patterns.
  • Biological Activity: A notable aspect of imidazo[1,2-a]quinoxaline is its potential biological activity. Research has indicated that derivatives of this compound exhibit various pharmacological effects, such as:
    • Antimicrobial properties
    • Anticancer effects
    • Neuroprotective capabilities
  • Applications: Its intriguing properties have led to a range of applications in:
    • Drug discovery
    • Development of fluorescent probes
    • Material science
  • Synthetic Routes: The synthesis of imidazo[1,2-a]quinoxaline can be approached through several methodologies, including:
    • Condensation reactions
    • Cyclization processes
    • Multicomponent reactions
  • Research Significance: Ongoing studies continue to explore its potential:
    "Compounds like imidazo[1,2-a]quinoxaline are essential in the quest for next-generation pharmaceuticals." - A leading researcher in medicinal chemistry.

As a compound bridging organic synthesis and pharmacology, imidazo[1,2-a]quinoxaline exemplifies the importance of heterocycles in modern science, making it a subject of interest for many researchers.

Synonyms
imidazo[1,2-a]quinoxaline
235-05-2
IMIDAZO(1,2-a)QUINOXALINE
BRN 0608447
SCHEMBL1417158
VTNBGTYLJIUATL-UHFFFAOYSA-
DTXSID70178063
AKOS006277660
InChI=1/C10H7N3/c1-2-4-9-8(3-1)12-7-10-11-5-6-13(9)10/h1-7H