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Indolizine

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Identification
Molecular formula
C8H7N
CAS number
271-28-5
IUPAC name
indolizine
State
State

At room temperature, indolizine is a solid.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.00
Boiling point (Celsius)
268.00
Boiling point (Kelvin)
541.00
General information
Molecular weight
117.16g/mol
Molar mass
117.1590g/mol
Density
1.0900g/cm3
Appearence

Indolizine is a white to pale yellow crystalline solid.

Comment on solubility

Solubility of Indolizine

Indolizine, with its molecular formula C8H7N, is a nitrogen-containing heterocyclic aromatic compound that exhibits some interesting solubility characteristics.

In general, the solubility of indolizine can be summarized as follows:

  • Polar Solvents: Indolizine is relatively soluble in polar solvents such as methanol and dimethyl sulfoxide (DMSO). This is primarily due to the ability to form hydrogen bonds with solvent molecules.
  • Non-Polar Solvents: It shows better solubility in non-polar solvents, including hexane and chloroform. The hydrophobic character of the compound enhances its interaction with non-polar environments.
  • Water Solubility: Indolizine's solubility in water is quite limited, which is typical for many organic molecules with low molecular weights that contain nitrogen.

As with many organic compounds, **temperature and concentration** can significantly influence solubility. It's important to note that:

  • Increased temperature typically enhances solubility.
  • Concentration can affect saturation levels, thus influencing precipitation or crystallization.

In summary, the solubility of indolizine showcases its ability to interact with various solvents, reflecting its structural characteristics while also demonstrating the broader principles of solubility in organic chemistry.

Interesting facts

Interesting Facts about Indolizine

Indolizine is a fascinating heterocyclic compound that occupies a unique position in the study of organic chemistry. This compound is notable for several reasons:

  • Structure and Isomerism: Indolizine comprises a fusion of a 5-membered and a 6-membered ring, which grants it one of the simplest structures among nitrogen-containing bicyclic compounds. Its structural complexity allows for various isomeric forms, further enriching its chemical behavior.
  • Biological Relevance: This compound and its derivatives have demonstrated significant biological activity. For instance, some indolizines exhibit antimicrobial and antitumor properties, making them subjects of interest in pharmaceutical research.
  • Research Applications: Indolizines are used in the synthesis of various organic compounds, especially in creating dyes, agrochemicals, and as molecular building blocks in organic synthesis.
  • Fluorescent Properties: Certain derivatives of indolizine exhibit strong fluorescent properties, which make them potential candidates for applications in optical devices and fluorescent sensors.

In the words of a renowned chemist, “Understanding compounds like indolizine not only expands our knowledge of organic chemistry but also unveils new avenues for innovation in drug design and materials science.”

Continuing exploration into the properties and applications of indolizine promises valuable insights that could lead to the development of more advanced materials and therapeutic agents.

Synonyms
INDOLIZINE
274-40-8
Pyrrolo[1,2-a]pyridine
Pyrrocoline
Indolizin
Pyrrocolin
4-Azaindene
Pyrrolo(1,2-a)pyridine
B48FMH8YFQ
MFCD00030189
CHEMBL3622747
CHEBI:35583
DTXSID50181818
4H-indolizine
UNII-B48FMH8YFQ
SCHEMBL7913
DTXCID90104309
BDBM50123663
AKOS005254677
AB01491
AS-77407
DB-047222
CS-0155664
P1943
D94752
EN300-209020
Q910641
691-518-1