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Ferric protoporphyrin IX

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Identification
Molecular formula
C34H32FeN4O4
CAS number
16009-13-5
IUPAC name
iron;3-[7,12,18-tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-porphyrin-21,22,23,24-tetraid-2-yl]propanoic acid
State
State

At room temperature, ferric protoporphyrin IX is a solid. It remains stable under normal conditions and is known for its characteristic crystalline form, which influences its appearance and reflective properties.

Melting point (Celsius)
300.00
Melting point (Kelvin)
573.15
Boiling point (Celsius)
196.00
Boiling point (Kelvin)
469.15
General information
Molecular weight
652.79g/mol
Molar mass
652.7930g/mol
Density
1.2805g/cm3
Appearence

Ferric protoporphyrin IX, commonly known as hemin, appears as a dark red crystalline powder. It is often described as having a metallic sheen due to its crystalline structure. In solution, particularly aqueous solutions, it typically displays a deep red coloration.

Comment on solubility

Solubility of Iron (3-[7,12,18-tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-8,13-dimethyl-porphyrin-21,22,23,24-tetraid-2-yl]propanoic Acid)

The solubility of the compound with the formula C34H32FeN4O4 can be considered through several important aspects:

  • Water Solubility: Due to the presence of multiple carboxylic acid groups in its structure, this compound is likely to be relatively soluble in water. The ionic nature of carboxyl functional groups can lead to good solvation in polar solvents.
  • Solvent Interaction: The solubility may significantly improve in environments rich in organic solvents, as the hydrophobic regions of the molecule can interact favorably with nonpolar solvents.
  • pH Dependence: The solubility could vary with changes in pH. In acidic conditions, protonation of the carboxylic groups may alter the solubility characteristics, making it less soluble at low pH.
  • Complex Formation: Iron(III) in this compound may engage in coordination with various ligands, which can impact solubility and dissociation in solution.

In summary, the compound's solubility is influenced by factors such as the presence of polar functional groups, the environment in which it is dissolved, and external conditions like pH. Understanding the solubility profile is crucial for applications in biological systems where solubility can affect bioavailability and activity.

Interesting facts

Iron Complex with Porphyrin Derivative

This intriguing compound combines the essential element iron with a complex porphyrin framework, showcasing the intricate relationships between inorganic and organic chemistry. Porphyrins are cyclic molecules that play critical roles in various biological systems, particularly in the transport of oxygen and electrons in living organisms. The structure of this specific iron porphyrin highlights a few noteworthy aspects:

  • Porphyrin Structure: The porphyrin core is comprised of a large, conjugated ring system that allows for extensive electron delocalization, which contributes significantly to its stability and reactivity.
  • Iron's Role: Iron ions are vital for numerous biochemical functions. By coordinating to the porphyrin, the iron ion becomes capable of both donating and accepting electrons, essential for redox reactions.
  • Carboxylic Acids: The presence of multiple carboxyethyl and carboxymethyl groups enhances solubility and can significantly affect the compound's interaction with biological systems, increasing its potential as a drug or imaging agent.
  • Applications in Medicine: Due to its structural characteristics, this compound is of interest in the development of metalloporphyrin-based drugs, which may offer therapeutic benefits in treating disorders such as cancer or anemia.

As noted by chemists, the coordination of metal ions to ligands like porphyrins exemplifies the fascinating interplay between structure and function in bioinorganic chemistry. Such compounds not only help us understand fundamental biological processes but also inspire new approaches in medicinal chemistry.

Overall, the study of iron complexes, particularly those with porphyrins, continues to be a vibrant field, contributing to advances in both theoretical and applied chemistry.