Skip to main content

Fenofibrate

ADVERTISEMENT
Identification
Molecular formula
C20H21ClO4
CAS number
49562-28-9
IUPAC name
isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate
State
State

Fenofibrate is typically encountered as a solid in its pure state at room temperature. It is usually in the form of a powder, which necessitates formulation enhancements to increase its dissolution for therapeutic purposes.

Melting point (Celsius)
79.00
Melting point (Kelvin)
352.15
Boiling point (Celsius)
473.90
Boiling point (Kelvin)
747.05
General information
Molecular weight
360.83g/mol
Molar mass
360.8290g/mol
Density
1.1698g/cm3
Appearence

Fenofibrate is a white or almost white crystalline powder. It is practically insoluble in water, but soluble in acetone, ethanol, and methanol. Due to its low solubility in water, fenofibrate formulations often require specific strategies like micronization to improve its bioavailability as a pharmaceutical product.

Comment on solubility

Solubility of Isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate

Isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate, often referred to in scientific literature for its unique properties, displays a fascinating profile when it comes to solubility.

Generally, the solubility of this compound can be influenced by several factors, including:

  • Polarity: Isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate exhibits moderate polarity due to its ester functional group, which can affect its behavior in various solvents.
  • Temperature: As with many organic compounds, an increase in temperature typically enhances solubility, enabling greater dissolution in organic solvents.
  • Solvent Type: The choice of solvent is critical. This compound tends to be more soluble in nonpolar or weakly polar solvents, such as hexane or ethyl acetate, rather than in highly polar solvents like water.

In practical applications, it is often noted that:

  • This compound demonstrates an ability to dissolve effectively in organic mixtures, which is beneficial for various chemical reactions and formulations.
  • Its limited solubility in water is a notable characteristic, specifying the need for careful selection of solvents in laboratory and industrial processes.

As researchers and chemists delve into the utilization of isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate, understanding its solubility traits will undoubtedly play a key role in optimizing its applications in the field.

Interesting facts

Interesting Facts about Isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate

Isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate is a fascinating compound that often captures the attention of chemists and researchers alike. Here are some insightful aspects of this complex structure:

  • Functional Groups: This compound contains multiple functional groups, including an ester and a phenyl propene moiety, which can significantly influence its chemical reactivity and properties.
  • Synthetic Applications: It serves as an important intermediate in synthetic organic chemistry, particularly in the development of pharmaceuticals and agrochemicals, due to its unique structural characteristics.
  • Drug Development: Researchers are investigating its potential as a drug delivery agent. The incorporation of the bulky isobutyl group may enhance the compound's lipophilicity, making it useful for transporting drugs across biological membranes.
  • Photoresponsive Properties: The presence of the alkenyl group allows for studies on photoresponsive behavior. This characteristic could lead to innovative applications in materials science and photochemistry.
  • Structure-Activity Relationship (SAR): Analyses of similar compounds can help in understanding how changes in the structure affect biological activity, which is vital for medicinal chemistry.

As illustrated, the compound isobutyl 2-(3-phenylprop-2-enoyloxy)benzoate is not just a simple structure; it holds numerous possibilities for research and innovation in multiple scientific fields. Its intriguing combination of various functional groups creates a platform for exploring new avenues in both theoretical and applied chemistry.