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isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate

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Identification
Molecular formula
C19H28N4O4
CAS number
142873-38-1
IUPAC name
isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate
State
State

At room temperature, the compound is in a solid state.

Melting point (Celsius)
212.00
Melting point (Kelvin)
485.20
Boiling point (Celsius)
646.30
Boiling point (Kelvin)
919.30
General information
Molecular weight
388.45g/mol
Molar mass
388.4530g/mol
Density
1.2300g/cm3
Appearence

The compound typically appears as a solid powder. It is often white or off-white in color and may have a crystalline structure.

Comment on solubility

Solubility of Isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate

The solubility of isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate can be influenced by several factors, making it an interesting subject of study. Due to its complex structure, the compound exhibits varied solubility characteristics in different solvents.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups such as carboxylate affects its solubility in polar solvents like water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can enhance its solubility in polar solvents.
  • Temperature: Increased temperature typically enhances the solubility of many compounds, including this one.

In general, it is expected that:

  • Isobutyl groups can contribute to its lipophilicity, potentially making it less soluble in water.
  • Solubility may increase in organic solvents, particularly those that can provide compatible interactions.

Several studies might report varying degrees of solubility, emphasizing that understanding the solubility profile is crucial for applications in pharmaceuticals and material science. Careful examination of solvent interactions can also help in predicting behavior in biological systems and facilitate formulation development.

Interesting facts

Interesting Facts about Isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate

Isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate is a fascinating compound with significant implications in medicinal chemistry and pharmacology. This compound belongs to the class of quinazoline derivatives, which are known for their broad range of biological activities. Here's why scientists and students find it intriguing:

  • Biological Significance: Quinazoline derivatives, including this compound, are often studied for their potential anti-cancer, anti-inflammatory, and anti-viral properties. They have a unique ability to interact with specific enzymes and receptors in the body.
  • Structure Functionality: The presence of both the piperazine and the quinazoline moieties provides a versatile scaffold for chemical modification. This structural diversity allows for the design of novel derivatives that can enhance therapeutic effectiveness.
  • Research Potential: Continuous research into compounds of this nature could lead to the discovery of new pharmaceutical agents. Scientists are eager to explore how modifications to the isobutyl group or other functional groups can influence the compound’s activity and selectivity.
  • Synthetic Pathways: The synthesis of such complex molecules is a thrilling challenge for chemists. The methodologies involved often include multi-step reactions and strategic functionalization, making it a perfect study subject for organic synthesis.

In addition to its practical applications, isobutyl 4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazine-1-carboxylate represents the intersection of chemistry and medicine, embodying the potential for small molecules to make a big impact in therapeutic areas. As we delve deeper into the study of such compounds, a quote by Nobel Laureate Ahmed Zewail rings true: “The future of chemistry is indeed exciting and broad, and this compound is a testament to that.”

This intriguing compound not only sparks curiosity among chemists but also serves as a reminder of the limitless possibilities inherent in chemical research.

Synonyms
CYZ88J9LRT
2-methylpropyl 4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carboxylate
19216-55-8
1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-, isobutyl ester
2-Methylpropyl 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxylate
1-Piperazinecarboxylic acid, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-, 2-methylpropyl ester