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Icariside II

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Identification
Molecular formula
C23H26N4O5
CAS number
58007-97-1
IUPAC name
isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate
State
State

At room temperature, Icariside II is in a solid state, existing as a crystalline powder.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
600.00
Boiling point (Kelvin)
873.15
General information
Molecular weight
500.57g/mol
Molar mass
500.5670g/mol
Density
1.3200g/cm3
Appearence

Icariside II typically appears as a pale yellow to off-white crystalline powder. It is often used in research contexts, especially in studies involving traditional medicine. The compound is sensitive to light and may degrade upon prolonged exposure.

Comment on solubility

Solubility of Isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate

The solubility of isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate exhibits characteristics influenced by its complex molecular structure. Understanding its solubility profile is crucial for its practical applications in pharmaceuticals and research.

Key Points on Solubility:

  • Polarity: The presence of functional groups, such as the carboxylate and the piperazine moiety, can increase the compound's polarity, potentially enhancing its solubility in polar solvents like water.
  • Hydrophobic Regions: Conversely, the isobutyl group contributes hydrophobic characteristics, which may lead to reduced solubility in aqueous environments.
  • Solvent Compatibility: Solubility may be greater in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), where non-polar characteristics become favorable.

As a rule of thumb, compounds that are more polar tend to be soluble in polar solvents, while non-polar substances prefer non-polar solvents. Therefore, investigations into the solubility of this compound should involve:

  1. Testing in various solvents to understand its solubility range.
  2. Considering temperature effects, as solubility can change with temperature fluctuations.
  3. Analyzing the impact of pH, particularly for ionizable groups.

In conclusion, the solubility of isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate is a multifaceted aspect that requires careful examination of structural features and environmental conditions.

Interesting facts

Interesting Facts about Isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate

Isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate is a fascinating compound that falls under the category of quinazoline derivatives. Here are some notable aspects that highlight its significance in the field of chemistry:

  • Pharmaceutical Potential: This compound exhibits a promising structural scaffold for drug discovery, particularly due to its potential development as an anti-cancer agent. Quinazoline derivatives have been extensively studied for their biological activities.
  • Mechanism Exploration: The presence of the piperazine moiety in the structure allows for unique interactions with biological targets. Researchers are actively investigating its mechanisms of action, hoping to unlock new pathways in disease treatment.
  • Synthetic Versatility: The synthesis of isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate can offer insights into various synthetic methodologies, aiding in the development of related compounds. Its derivation from readily available starting materials makes it an excellent candidate for further modifications.
  • Natural Product Inspiration: Quinazoline-containing compounds are often inspired by natural products, providing a bridge between synthetic chemistry and the treasures of nature. This inspires chemists to explore the biosynthetic pathways that can lead to novel derivatives.
  • Collaborative Research: Given its complexity, research on this compound often requires a multi-disciplinary approach, incorporating medicinal chemistry, pharmacology, and even computational chemistry to predict and model interactions.

In summary, isobutyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate not only highlights the complexity of organic synthesis but also serves as a pathway to unveil new therapeutic strategies. As John McCarthy once said, "The essential aspect of creativity is not being afraid to fail." This compound embodies that spirit, encouraging scientists to innovate and explore uncharted territories in chemistry.

Synonyms
PIQUIZIL
21560-58-7
Piquizil [INN]
piquizilo
1K46616F1O
UNII-1K46616F1O
DTXSID70175895
1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-METHYLPROPYL ESTER
piquizilum
RefChem:174501
DTXCID6098386
2-methylpropyl 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate
SCHEMBL1817479
CHEMBL2110991
NS00123924
Q27252521