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Phthalide

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Identification
Molecular formula
C8H6O2
CAS number
87-41-2
IUPAC name
isochromane-1,3-dione
State
State

At room temperature, phthalide is typically in a solid state.

Melting point (Celsius)
72.00
Melting point (Kelvin)
345.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
134.13g/mol
Molar mass
134.1310g/mol
Density
1.3480g/cm3
Appearence

Phthalide typically appears as a colorless to pale yellow crystalline solid. It may have a weak almond-like aroma. When pure, it is often found in white crystalline form.

Comment on solubility

Solubility of isochromane-1,3-dione

Isochromane-1,3-dione, a compound characterized by its unique structure, exhibits specific solubility properties that can be quite intriguing. Understanding the solubility of this compound can provide insights into its behavior in various solvents.

Key Solubility Characteristics:

  • Solvent Dependence: Isochromane-1,3-dione tends to be soluble in a variety of organic solvents, including ethyl acetate and dimethyl sulfoxide (DMSO), due to its polar functional groups.
  • Temperature Influence: Increased temperatures generally enhance solubility; therefore, warming the solvent can facilitate the dissolution process.
  • Polarity Consideration: Given its structure, isochromane-1,3-dione is more likely to dissolve in solvents with similar polar characteristics, showing limited solubility in non-polar solvents.

As one might conclude, the solubility of isochromane-1,3-dione is influenced by several factors, promoting its behavior as a polar compound. Notably, when attempting to dissolve this compound, a good practice is to:

  1. Start with polar solvents to achieve better solubility.
  2. Adjust temperature as needed to enhance the dissolution.

In summary, the solubility of isochromane-1,3-dione is a critical property that not only affects its practical applications but also drives interesting chemical interactions, making it a compound worth exploring in various scientific contexts.

Interesting facts

Interesting Facts about Isochromane-1,3-dione

Isochromane-1,3-dione is a fascinating compound within the realm of organic chemistry. This compound is characterized by its unique structural features and potential applications. Here are some intriguing aspects of isochromane-1,3-dione:

  • Cyclic Structure: Isochromane-1,3-dione possesses a bicyclic structure that combines elements of both isochromane and dione functionalities. This makes it an interesting subject for exploration in chemical synthesis.
  • Diverse Applications: Due to its unique reactivity, isochromane-1,3-dione can be a precursor in the synthesis of various biologically active compounds, including pharmaceuticals and agrochemicals.
  • Potential Biological Activity: Research has indicated that derivatives of isochromane compounds may exhibit significant biological activity, potentially making them useful in the development of new medicinal agents.
  • Reactivity Insights: The presence of keto groups within the compound can enhance its electrophilic character, making it an interesting candidate for further studies in reactivity and mechanistic pathways.
  • Synthetic Routes: Various synthetic methods have been developed to create isochromane derivatives, showcasing the compound's versatility and enabling further functionalization.

In conclusion, isochromane-1,3-dione stands out as an exceptional compound in organic chemistry, bridging the gap between simple cyclic structures and complex synthetic applications. Its potential in medicinal chemistry is particularly exciting for scientists and researchers alike, inspiring continued investigation into its reactivity and functional uses.

Synonyms
HOMOPHTHALIC ANHYDRIDE
703-59-3
Homophthalic acid anhydride
Benzoglutaric anhydride
DZ8M2RM8MF
NSC 2825
NSC-2825
EINECS 211-873-4
NSC 401693
NSC-401693
3,4-2H-Isocoumarin-3-one
DTXSID00220569
DTXCID80143060
akhsbavqpirvag-uhfffaoysa-n
Isochroman-1,3-dione
1,3-Isochromandione
1H-2-Benzopyran-1,3(4H)-dione
4H-isochromene-1,3-dione
MFCD00006894
3,4-dihydro-1H-2-benzopyran-1,3-dione
4H-2-benzopyran-1,3-dione
1H-Isochromene-1,3(4H)-dione
isochromane-1,3-dione
homophtalic anhydride
o-Carboxyphenylacetic acid cyclic anhydride
UNII-DZ8M2RM8MF
2-benzopyran-1,3(4H)dione
SCHEMBL149855
Homophthalic anhydride (2-Carboxyphenylacetic anhydride)
NSC2825
1H-Isochromene-1,3(4H)-dione #
NSC401693
AKOS000120712
CS-W010863
FC54873
SY014662
DB-055408
H1346
NS00037049
EN300-21680
F21267
F0001-1819
Z104508708
1,3-Isochromandione;Homophthalic acid anhydride;Homophthalic anhydride