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Isonicotinic acid

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Identification
Molecular formula
C6H5NO2
CAS number
55-22-1
IUPAC name
isonicotinic acid
State
State
At room temperature, isonicotinic acid is in a solid state, appearing as a white crystalline powder.
Melting point (Celsius)
310.00
Melting point (Kelvin)
583.15
Boiling point (Celsius)
301.00
Boiling point (Kelvin)
574.15
General information
Molecular weight
123.11g/mol
Molar mass
123.1100g/mol
Density
1.4000g/cm3
Appearence

Isonicotinic acid is a white crystalline powder.

Comment on solubility

Solubility of Isonicotinic Acid (C6H5NO2)

Isonicotinic acid is a heterocyclic aromatic carboxylic acid that exhibits interesting solubility properties. Understanding its solubility is crucial for its applications in pharmaceutical and chemical synthesis. Here are some key points about its solubility:

  • Water Solubility: Isonicotinic acid is moderately soluble in water, with solubility often cited around 3.1 g/100 mL at room temperature. This solubility makes it suitable for aqueous reactions and applications.
  • Solvent Compatibility: It dissolves well in organic solvents such as ethanol and methanol, which enhances its versatility in various chemical processes.
  • Influence of pH: The solubility of isonicotinic acid can increase in basic conditions due to the ionization of its carboxylic acid group, which makes it more soluble in aqueous environments.
  • Hydrogen Bonding: The presence of both the carboxylic acid group and the nitrogen in the pyridine ring facilitates hydrogen bonding, further influencing its solubility in different solvents.

As stated, "The structure and functional groups of a compound play a pivotal role in its solubility." For Isonicotinic acid, this is evidenced by its behavior in different solvents and pH levels, highlighting its significance in both research and industrial applications.

Interesting facts

Interesting Facts about Isonicotinic Acid

Isonicotinic acid, often recognized for its unique role in the world of chemistry, is a structural isomer of nicotinic acid. This compound has gained significant attention due to its diverse applications and industrial importance. Here are some captivating aspects of isonicotinic acid:

  • Biochemical Role: Isonicotinic acid is known to be a precursor for the synthesis of vitamin B6, which plays a crucial role in numerous biological processes, including amino acid metabolism.
  • Pharmaceutical Applications: This compound serves as a key building block in the manufacture of various drugs, notably in the development of antitubercular agents such as isoniazid, which is essential in tuberculosis treatment.
  • Research Interest: Scientists are actively researching isonicotinic acid for its potential utility in developing novel antimicrobial agents, owing to its structural advantages and biological activity.
  • Synthesis Techniques: There are several methods for synthesizing isonicotinic acid, including cyclization reactions of pyridine derivatives, showcasing the versatility of organic synthesis techniques.
  • Commercial Value: Beyond its pharmaceutical importance, isonicotinic acid is also utilized in the production of agrochemicals and dyes, reflecting its adaptability across different industries.

In essence, isonicotinic acid is not merely a compound of academic interest; it embodies a significant bridge between basic research and practical applications, making it a vital subject of study in both organic chemistry and medicinal science.

“Understanding the role of compounds like isonicotinic acid is essential for the advancement of modern medicine and chemistry.”

Synonyms
ISONICOTINIC ACID
55-22-1
4-Pyridinecarboxylic acid
Pyridine-4-carboxylic acid
4-Picolinic acid
4-Carboxypyridine
gamma-Picolinic acid
p-Pyridinecarboxylic acid
.gamma.-Picolinic acid
gamma-Pyridinecarboxylic acid
Acide iso-nicotinique
1,4-Dihydroisonicotinic acid
Acide iso-nicotinique [French]
MFCD00006429
AI3-19239
NSC 1483
NSC-1483
EINECS 200-228-2
Y8SYN761TQ
.gamma.-pyridinecarboxylic acid
CHEBI:6032
DTXSID8020757
isonicotinic-d4 acid
DTXCID80757
ISONICOTINIC ACID [MI]
ISONICOTINIC ACID [WHO-DD]
pyridine, 4-carboxy-
ISONIAZID IMPURITY A [EP IMPURITY]
Pyridine-4-carboxylic Acid (Isonicotinic Acid)
163751-04-0
isonicotinicacid
ISONIAZID IMPURITY A (EP IMPURITY)
UNII-Y8SYN761TQ
4Carboxypyridine
4Picolinic acid
isonicotonic acid
gammaPicolinic acid
Acide isonicotinique
MN1
Pyridine-4-carboxylic Acid; Nicotinic Acid Imp. E (EP); Isonicotinic Acid; Isoniazid Impurity A; Nicotinic Acid Impurity E
S3V
pPyridinecarboxylic acid
.alpha.-Picolinic acid
4Pyridinecarboxylic acid
Pyridine4carboxylic acid
Isonicotinic acid, 99%
4-pyridine-carboxylic acid
Biomol-NT_000289
bmse000133
gammaPyridinecarboxylic acid
SCHEMBL1108
CHEMBL1203
Pyridinecarboxylic acid-(4)
Oprea1_749724
4-Pyridinecarboxylic acid; Pyridine-4-carboxylic acid
BPBio1_001365
NSC1483
HY-I0736
STR00113
Tox21_200502
AC8088
s6014
STL168892
AKOS000118918
AB00757
BS-3754
CS-W020040
FI37886
CAS-55-22-1
NCGC00163295-01
NCGC00163295-02
NCGC00258056-01
SY002246
DB-013378
Isonicotinic acid, purum, >=99.0% (T)
I0207
NS00022363
EN300-19169
C07446
Isonicotinic acid, SAJ special grade, >=99.0%
AC-907/25014347
Q410465
F2191-0075
InChI=1/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9
200-228-2
Isonicotinic acid; Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid