Skip to main content

Isopropyl fluoroacetate

ADVERTISEMENT
Identification
Molecular formula
C5H9FO2
CAS number
558-86-7
IUPAC name
isopropyl 2-fluoroacetate
State
State

At room temperature, isopropyl fluoroacetate is typically present as a liquid. It is volatile and can evaporate at ambient conditions.

Melting point (Celsius)
-95.00
Melting point (Kelvin)
178.15
Boiling point (Celsius)
109.00
Boiling point (Kelvin)
382.15
General information
Molecular weight
122.12g/mol
Molar mass
122.1100g/mol
Density
1.0530g/cm3
Appearence

Isopropyl fluoroacetate is a clear liquid. It is often colorless but may appear slightly yellow if it is impure or has been exposed for some time to sunlight or air due to potential degradation.

Comment on solubility

Solubility of Isopropyl 2-Fluoroacetate

The solubility of isopropyl 2-fluoroacetate (C5H9F1O2) is a key characteristic that influences its behavior in various applications. Understanding its solubility can provide insights into its reactivity and potential uses.

Here are some important points about its solubility:

  • Polar Nature: Isopropyl 2-fluoroacetate is a polar molecule due to the presence of both the fluorine atom and the ester functional group, which tend to engage in hydrogen bonding and dipole-dipole interactions.
  • Solvent Compatibility: It is generally soluble in organic solvents such as ethanol and acetone, but its solubility in water is limited. This indicates that while it can dissolve well in non-polar or slightly polar solvents, it shows poor affinity for water, a property often summarized by the phrase "like dissolves like."
  • Temperature Dependence: The solubility can also be affected by temperature; higher temperatures may increase solubility in organic solvents.

In summary, while isopropyl 2-fluoroacetate demonstrates certain solubility tendencies in organic media, it is essential to consider the context of its application to understand how solubility influences its reactivity and usability effectively. Observations in various solvents can aid in determining the optimal conditions for its use.

Interesting facts

Interesting Facts About Isopropyl 2-Fluoroacetate

Isopropyl 2-fluoroacetate is a fascinating compound with a range of applications, particularly in the field of organic chemistry. Here are some intriguing insights:

  • Versatile Applications: This compound is often utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its ability to introduce fluorine into organic molecules makes it valuable in drug design and development.
  • Fluorine’s Unique Properties: The presence of fluorine in organic compounds typically enhances their metabolic stability and can modulate biological activity. This characteristic is one reason why fluorinated compounds, including isopropyl 2-fluoroacetate, are of great interest in medicinal chemistry.
  • Mechanistic Insights: Understanding the reactivity of isopropyl 2-fluoroacetate can provide valuable insights into nucleophilic substitution reactions. The presence of the fluorine atom influences the electron density and can impact reaction pathways.
  • Environmental Considerations: As with many fluorinated compounds, scientists are studying the environmental impact and degradation pathways of isopropyl 2-fluoroacetate. Awareness of its fate in ecological systems is essential for sustainable chemical practices.
  • Chemical Education: This compound serves as an excellent example for chemistry students learning about functional groups, reaction mechanisms, and the significance of halogens in organic compounds. Its unique structure and reactivity can spark discussions in various chemistry courses.

In summary, isopropyl 2-fluoroacetate is much more than a simple compound; it embodies the complexities of halogenated organic chemistry and serves various practical applications, making it a subject of interest for chemists and researchers alike. Exciting ongoing research continues to reveal its potential!

Synonyms
406-06-4
ACETIC ACID, FLUORO-, ISOPROPYL ESTER
Isopropyl fluoroacetate
propan-2-yl 2-fluoroacetate
TL 630
BRN 1744814
SCHEMBL24083543
DTXSID60193604
fluoroacetic acid, 1-methylethyl ester