Skip to main content

Fenofibrate

ADVERTISEMENT
Identification
Molecular formula
C20H21Cl2O4
CAS number
49562-28-9
IUPAC name
isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate
State
State

At room temperature, fenofibrate is typically found as a solid.

Melting point (Celsius)
80.00
Melting point (Kelvin)
353.15
Boiling point (Celsius)
314.00
Boiling point (Kelvin)
587.15
General information
Molecular weight
360.83g/mol
Molar mass
360.8330g/mol
Density
1.2010g/cm3
Appearence

Fenofibrate appears as a white solid powder that is crystalline in nature. It is mostly known for its use as a lipid-lowering medication in the treatment of high cholesterol. The powder is odorless and stable under normal storage conditions.

Comment on solubility

Solubility Characteristics of Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate

Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate, a complex organic compound, exhibits unique solubility properties that are worthy of discussion. Understanding its solubility behavior can be pivotal for various applications, especially in pharmaceuticals and industrial formulations.

General Solubility Behavior

While specific solubility values can be influenced by factors such as temperature and pH, some general trends can be noted:

  • Solvent Influence: This compound tends to be more soluble in organic solvents, such as ethanol and acetone, than in water. This is due to the hydrophobic nature imparted by the chlorophenyl groups.
  • Hydrogen Bonding: The presence of the hydroxy group in its structure can engage in hydrogen bonding, which may enhance solubility in polar solvents to a certain extent.
  • Temperature Dependency: Like many compounds, solubility generally increases with temperature; hence, heating might improve its dissolution in less ideal solvents.

Key Considerations

When working with isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate, consider the following:

  • Stability: Ensure that the solvent used does not react with the compound.
  • Concentration: Higher concentrations may lead to precipitation, especially in less favorable solvents.
  • Environmental Impact: As it demonstrates limited water solubility, proper disposal methods should be adhered to when dealing with waste.

In summary, the solubility of isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate is a multifaceted subject, requiring careful attention to solvent choice and environmental considerations. Understanding these solubility characteristics can facilitate better utilization in various applications.

Interesting facts

Interesting Facts about Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate

Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate, commonly known within the realm of chemistry for its unique structural features and applications, is a fascinating compound that showcases the versatility of organic chemistry.

Key Features

  • Chlorophenyl Groups: This compound contains two 4-chlorophenyl groups which contribute to its biological activity. Chlorine atoms can significantly enhance the properties of organic molecules by altering their reactivity and solubility.
  • Hydroxy and Acetate Functionalities: The presence of both the hydroxy (-OH) and acetate (-OCOCH₃) groups makes this compound an interesting candidate for various chemical reactions, such as esterification and nucleophilic substitutions.

Applications in the Field

Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate has garnered attention due to its applications, which include:

  • Pesticide Development: Its structure implies potential use in agrochemicals, especially in the creation of herbicides or insecticides.
  • Pharmaceutical Research: The compound's unique properties make it a candidate for research in medicinal fields, particularly in developing new therapeutics.

Noteworthy Characteristics

From a scientific perspective, the examination of this compound is compelling for several reasons:

  • Biological Activity: Studies have shown that many chlorinated compounds exhibit significant antimicrobial or herbicidal properties due to their ability to disrupt cellular functions.
  • Green Chemistry: The synthesis techniques employed in producing derivatives of this compound are increasingly aligned with the principles of green chemistry, aiming to reduce hazardous substances in chemical reactions.

In conclusion, Isopropyl 2,2-bis(4-chlorophenyl)-2-hydroxy-acetate is not only a remarkable example of organic compound synthesis but also a testament to the evolving field of chemistry where functional groups dictate potency and application in real-world scenarios.

Synonyms
CHLOROPROPYLATE
Rospine
Caswell No. 511B
GI03ROM7HQ
DTXSID5041778
CHEBI:39411
HSDB 1732
Isopropyl-4,4'-dichlorobenzilate
Chloropropylate [ANSI:BSI:ISO]
EINECS 227-421-4
UNII-GI03ROM7HQ
EPA Pesticide Chemical Code 026801
BRN 2757308
CHLOROPROPYLATE [ISO]
CHLOROPROPYLATE [HSDB]
AI3-26999
DTXCID3021778
propan-2-yl bis(4-chlorophenyl)(hydroxy)acetate
ENT-26999
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxy-1-methylethyl ester
4-10-00-01276 (Beilstein Handbook Reference)
Chloropropylate (ANSI:BSI:ISO)
Propyl p,p'dichlorobenzilate
Isopropyl4,4'dichlorobenzilate
Isopropyl 4,4'dichlorobenzilate
ENT 26999
USEPA/OPP Pesticide Code: 026801
Isopropylester kyseliny 4,4'dichlorbenzilove
Benzilic acid, 4,4'dichloro, isopropyl ester
Isopropyl 2(4,4'dichlorophenyl)2hydroxyacetate
isopropyl-2-hydroxy-2,2-di(p-chlorophenyl) acetate
1Methylethyl 4chloroalpha(4chlorophenyl)alphahydroxybenzeneacetate
Benzeneacetic acid, 4chloroalpha(4chlorophenyl)alphahydroxy1methylethyl ester
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxy-1-methylethyl ester (9CI)
Benzeneacetic acid, 4chloroalpha(4chlorophenyl)alphahydroxy, 1methylethyl ester
Benzeneacetic acid, 4chloroalpha(4chlorophenyl)alphahydroxy, 1methylethyl ester (9CI)
Benzeneacetic acid, 4chloroalpha(4chlorophenyl)alphahydroxy1methylethyl ester (9CI)
227-421-4
axgubxvwzbfqga-uhfffaoysa-n
un2761
Chlorpropylate
5836-10-2
Chlorpropylat
Acaralate
Rospin
Isopropyl 4,4'-dichlorobenzilate
Chlormite
Gesakur
Rospan
Geigy 24163
Benzilic acid, 4,4'-dichloro-, isopropyl ester
ENT 26,999
1-Methylethyl 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxybenzeneacetate
G 24,163
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxy-, 1-methylethyl ester
propan-2-yl 2,2-bis(4-chlorophenyl)-2-hydroxyacetate
Chloropropylate 10 microg/mL in Isooctane
Chloropropylate 1000 microg/mL in Acetone
Isopropylester kyseliny 4,4'-dichlorbenzilove
Benzeneacetic acid, 4-chloro-.alpha.-(4-chlorophenyl)-.alpha.-hydroxy-, 1-methylethyl ester
Chlorpropylat [Czech]
Propyl p,p'-dichlorobenzilate
G 24163
BIDD:ER0168
SCHEMBL164178
Isopropyl 2-(4,4'-dichlorophenyl)-2-hydroxyacetate
Isopropylester kyseliny 4,4'-dichlorbenzilove [Czech]
CHEMBL1552611
Tox21_301914
AKOS040748131
NCGC00166181-01
NCGC00255485-01
CAS-5836-10-2
NS00022422
C19027
Chlorpropylat, PESTANAL(R), analytical standard
Isopropyl bis(4-chlorophenyl)(hydroxy)acetate #
Q27119854
1-Methylethyl 4-chloro-.alpha.-(4-chlorophenyl)-.alpha.-hydroxybenzeneacetate