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sulfaquinoxaline

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Identification
Molecular formula
C14H12N4O2S
CAS number
59-40-5
IUPAC name
isopropyl 4-amino-2-sulfamoyl-benzoate
State
State

Solid: Sulfaquinoxaline is in a solid state at room temperature. As a crystalline powder, it demonstrates stability under typical laboratory conditions but should be stored in a well-sealed container to prevent moisture uptake and degradation.

Melting point (Celsius)
253.50
Melting point (Kelvin)
526.60
Boiling point (Celsius)
596.30
Boiling point (Kelvin)
869.50
General information
Molecular weight
300.35g/mol
Molar mass
300.3470g/mol
Density
1.5900g/cm3
Appearence

Sulfaquinoxaline typically appears as a white or slightly yellowish crystalline powder. It is stable under normal conditions but should be kept away from strong oxidizing agents.

Comment on solubility

Solubility of Isopropyl 4-amino-2-sulfamoyl-benzoate

Isopropyl 4-amino-2-sulfamoyl-benzoate, a sulfonamide derivative, exhibits varying solubility characteristics that are important in both pharmaceutical and chemical applications. Understanding the solubility properties of this compound can be crucial for its effectiveness and usability. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the sulfamoyl group enhances the polar nature of isopropyl 4-amino-2-sulfamoyl-benzoate, which typically favors solubility in polar solvents such as water.
  • Solvent Dependency: Solubility is significantly influenced by the solvent used. In general, it is expected that this compound is soluble in water due to the presence of hydrogen bonding capability.
  • pH Influence: The solubility may increase in more alkaline conditions as deprotonation of the amino group can occur, leading to improved solubility in the aqueous phase.
  • Concentration Matters: As with many compounds, solubility can also be concentration-dependent, where lower concentrations may lead to increased solubility at ambient temperatures.

In summary, the solubility of isopropyl 4-amino-2-sulfamoyl-benzoate is influenced by a variety of factors including its polar character, the choice of solvent, pH levels, and concentration. Thus, for practical applications, testing for solubility in specific conditions is essential to predict behavior effectively and ensure proper formulation.

Interesting facts

Interesting Facts about Isopropyl 4-Amino-2-Sulfamoyl-Benzoate

Isopropyl 4-amino-2-sulfamoyl-benzoate is an intriguing compound that belongs to the class of sulfanilamide derivatives. This compound holds significance mainly in medicinal chemistry and offers various applications:

  • Medicinal Use: It is known for its antibacterial properties, making it a valuable component in the development of antimicrobial agents.
  • Sulfamoyl Group: The presence of the sulfamoyl functional group can enhance biological activity, as it can interact with bacterial dihydropteroate synthase, a key enzyme involved in folate synthesis.
  • Structure-Activity Relationship: The structure of this compound is essential for its efficacy. The amino and sulfamoyl groups are crucial for its ability to inhibit microbial growth.
  • Research Significance: Scientists are actively exploring derivatives of sulfanilamides like this compound for their potential to combat antibiotic resistance, which is a growing global health concern.

Additionally, the compound is used as a model system in pharmacological research to study metabolic pathways and enzyme inhibition. As the field of medicinal chemistry progresses, compounds like isopropyl 4-amino-2-sulfamoyl-benzoate provide a foundation for understanding the pharmacodynamics and pharmacokinetics of sulfonamide drugs.

In summary, this compound not only showcases the complexity of chemical interactions but also stands as a testament to the continuous evolution of drug discovery and development.

Synonyms
320-90-1
GHH-SC2
Isopropyl 4-amino-2-sulfamoylbenzoate
propan-2-yl 4-amino-2-sulfamoylbenzoate
4-Amino-2-sulfamoylbenzoic acid isopropyl ester
NSC 114739
BRN 2699248
DTXSID90185830
BENZOIC ACID, 4-AMINO-2-SULFAMOYL-, ISOPROPYL ESTER
Benzoic acid,4-amino-2-(aminosulfonyl)-, 1-methylethyl ester
Benzoic acid, 4-amino-2-(aminosulfonyl)-, 1-methylethyl ester
Benzoic acid, 4-amino-2-(aminosulfonyl)-, 1-methylethyl ester (9CI)
NSC114739
NSC-114739
DS-007180