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Chlorambucil

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Identification
Molecular formula
C14H19Cl2N1O2
CAS number
305-03-3
IUPAC name
isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate
State
State

At room temperature, chlorambucil exists as a solid. It is stable under normal conditions but should be protected from moisture and light to maintain its efficacy.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
340.00
Boiling point (Kelvin)
613.15
General information
Molecular weight
304.21g/mol
Molar mass
304.2050g/mol
Density
1.3010g/cm3
Appearence

Chlorambucil is typically a yellow-tan crystalline powder. It may appear as white or off-white depending on the level of purity. It is not highly soluble in water but can dissolve in organic solvents.

Comment on solubility

Solubility of Isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate

The solubility of isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate can be characterized as a complex phenomenon due to its unique chemical structure. Understanding its solubility is critical for various applications, particularly in the fields of pharmaceuticals and agrochemicals. Here are some key points to consider:

  • Solvent Polarity: The solubility of this compound may vary significantly with the polarity of the solvent used. Generally, it is more soluble in polar organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • Temperature Effects: As with many chemical compounds, an increase in temperature tends to enhance solubility. Therefore, heating the solvent can provide better dissolution.
  • pH Influence: The solubility can also be affected by the pH of the solution, which influences the ionization of certain functional groups within the molecule.
  • Crystallization Potential: Due to its structure, isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate may have a tendency to crystallize, affecting its effective concentration in solution.

Overall, it can be said that the solubility of this compound is influenced by a multitude of factors; hence, extensive experimentation may be essential to determine optimal conditions for its use in different applications. As often stated in the realm of chemistry, "the solution to problems lies in understanding solubility."

Interesting facts

Interesting Facts about Isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate

Isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate is a fascinating compound with a variety of applications, particularly in pharmaceuticals and chemical research. Here are some noteworthy aspects:

  • Pharmaceutical Relevance: This compound is often explored in the field of medicinal chemistry for its potential use as an anticancer agent. The presence of the bis(2-chloroethyl)amino group suggests that it may operate by alkylating DNA, a mechanism commonly utilized by chemotherapeutic agents.
  • Structural Complexity: The structure includes a carbamate moiety, which is known for its ability to enhance the lipophilicity and bioavailability of drugs. This design allows for improved absorption and distribution within biological systems.
  • Mechanism of Action: The bis(2-chloroethyl)amino group plays a critical role in the compound's mechanism of action. Its ability to form reactive intermediates capable of binding to DNA is crucial for inducing cell death in rapidly dividing cancer cells.
  • Research Potential: Scientists are continuously investigating derivatives of this compound, aiming to optimize its effectiveness and reduce potential side effects. Structure-activity relationship (SAR) studies are key in this regard, helping researchers identify which modifications yield greater therapeutic benefits.
  • Safety Considerations: As with many compounds featuring chloroethyl groups, careful consideration must be given to the toxicity and safety profiles of isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate. Ongoing research is essential to ensure that any therapeutic applications are both effective and safe for patients.

In summary, isopropyl N-[4-[bis(2-chloroethyl)amino]phenyl]carbamate stands out not only for its intricate molecular structure and potential as a therapeutic agent but also for the ongoing research that seeks to unlock its full capabilities in the fight against cancer.

Synonyms
2045-44-5
CARBANILIC ACID, p-(BIS(2-CHLOROETHYL)AMINO)-, ISOPROPYL ESTER
BRN 2817008
Isopropyl p-(bis(2-chloroethyl)amino)carbanilate
DTXSID70174409