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Isoquinoline-5,8-dione

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Identification
Molecular formula
C9H5NO2
CAS number
130-06-5
IUPAC name
isoquinoline-5,8-dione
State
State

At room temperature, isoquinoline-5,8-dione is a solid. Its crystalline nature and distinct yellow color contribute to its recognizability and handling ease at ambient conditions.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
254.00
Boiling point (Kelvin)
527.15
General information
Molecular weight
159.14g/mol
Molar mass
159.1420g/mol
Density
1.3660g/cm3
Appearence

Isoquinoline-5,8-dione appears as a yellow crystalline solid. The compound exhibits a distinct and vibrant color which is often used as an identifying feature. Its crystalline nature contributes to its solid state at room temperature.

Comment on solubility

Solubility of isoquinoline-5,8-dione (C9H5NO2)

Isoquinoline-5,8-dione exhibits interesting solubility characteristics that are important for its practical applications. Here are key points regarding its solubility:

  • Solvent Dependence: Isoquinoline-5,8-dione is known to be soluble in organic solvents such as dichloromethane and ethanol. This makes it easier to handle in various chemical processes.
  • Water Solubility: The compound has limited solubility in water, attributed to its relatively non-polar isoquinoline structure and the presence of a carbonyl group which does not interact favorably with water.
  • Temperature Effects: Temperature can play a significant role in solubility; generally, an increase in temperature may enhance solubility in organic solvents.
  • pH Effects: The solubility of isoquinoline-5,8-dione can be affected by the pH of the solution, particularly as ionization occurs in varying pH values, which may increase aqueous solubility under certain conditions.

In conclusion, while isoquinoline-5,8-dione has limited aqueous solubility, its compatibility with organic solvents opens up a range of possibilities for its use in synthetic and analytical chemistry. As with many chemical compounds, understanding the solubility can lead to more effective applications in a variety of fields.

Interesting facts

Interesting Facts about Isoquinoline-5,8-Dione

Isoquinoline-5,8-dione is a fascinating compound that belongs to the family of isoquinoline derivatives, which have garnered significant interest in the fields of medicinal chemistry and organic synthesis. Here are some compelling highlights about this intriguing compound:

  • Structure and Significance: Isoquinoline-5,8-dione features a bicyclic structure that is central to numerous biological activities. Its unique arrangement contributes to its reactivity and solubility properties.
  • Biological Activities: Compounds containing the isoquinoline skeleton have been found to exhibit a wide range of pharmacological activities, including:
    • Antimicrobial
    • Antitumor
    • Anti-inflammatory
  • Research Applications: Scientists are investigating isoquinoline-5,8-dione for its potential in drug development. The compound has shown promise in the synthesis of novel drugs targeting various diseases.
  • Natural Occurrence: Several naturally occurring isoquinoline alkaloids, derived from plants, share structural characteristics with isoquinoline-5,8-dione, highlighting its significance in nature. Some of these alkaloids have been used in traditional medicine.
  • Reactivity: The diketone functional groups of isoquinoline-5,8-dione allow it to participate in various chemical reactions, including condensation reactions and Michael additions, making it a valuable intermediate in organic synthesis.

In essence, isoquinoline-5,8-dione not only exemplifies an interesting molecular structure but also serves as a pivotal compound influencing modern scientific research. As the field of chemistry continues to evolve, the exploration of such compounds will undoubtedly lead to exciting discoveries and advancements.

Synonyms
5,8-ISOQUINOLINEDIONE
Isoquinoline-5,8-dione
50-46-4
NSC 76882
BRN 1525151
5-21-11-00263 (Beilstein Handbook Reference)
DTXSID10198164
NSC-76882
NSC76882
CF6NRA2TVB
isoquinoline-5,8-quinone
NCIOpen2_000894
CHEMBL81679
SCHEMBL6186385
DTXCID40120655
CUPFSRUOCULQSY-UHFFFAOYSA-N
AKOS006276227