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Roflumilast

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Identification
Molecular formula
C17H27N3O4S
CAS number
162401-32-3
IUPAC name
methanesulfonate;[3-methoxy-4-(4-phenylbutoxy)phenyl]ammonium
State
State

Roflumilast is typically in a solid state at room temperature.

Melting point (Celsius)
158.50
Melting point (Kelvin)
431.65
Boiling point (Celsius)
325.00
Boiling point (Kelvin)
598.15
General information
Molecular weight
482.95g/mol
Molar mass
482.9470g/mol
Density
1.2600g/cm3
Appearence

Roflumilast is a white to off-white, crystalline powder.

Comment on solubility

Solubility of Methanesulfonate; 3-methoxy-4-(4-phenylbutoxy)phenyl Ammonium

The solubility of the compound methanesulfonate; 3-methoxy-4-(4-phenylbutoxy)phenyl ammonium can be quite intriguing due to its unique chemical structure. In general, the solubility of ionic compounds is influenced by several key factors:

  • Ionic Strength: The presence of methanesulfonate, a known anionic group, tends to enhance solubility in polar solvents.
  • Hydrophobic Interactions: The bulky phenylbutoxy group can lead to decreased solubility in non-polar solvents due to hydrophobic interactions.
  • Temperature: Increasing temperature usually enhances solubility for many compounds, making it a useful parameter to consider.
  • pH Levels: Changes in pH can affect the ionization state of the ammonium group, further influencing solubility behavior.

Experts often state, "The solubility of a compound in water can provide critical insights into its biological activity and interaction with other molecules." For this compound, it is reasonable to expect it to have moderate solubility in aqueous solutions, especially considering methanesulfonate's favorable properties. However, further experimental data would be necessary to fully characterize the extent of this solubility across various solvents and conditions.


In conclusion, while the anticipated solubility profile can be speculated based on molecular structure and known behaviors of similar compounds, empirical testing will yield the most reliable results.

Interesting facts

Interesting Facts About Methanesulfonate; [3-Methoxy-4-(4-phenylbutoxy)phenyl]ammonium

Methanesulfonate; [3-methoxy-4-(4-phenylbutoxy)phenyl]ammonium is a fascinating compound with a variety of applications and properties:

  • Application in Pharmaceuticals: This compound has been studied for its potential use in drug formulations due to its ability to enhance solubility and bioavailability of active pharmaceutical ingredients.
  • Role as a Surfactant: It exhibits surfactant properties which make it beneficial in the formulation of cleaning agents and detergents.
  • Chemical Structure: The presence of a methoxy group and a long phenylbutoxy chain results in unique interaction characteristics, allowing it to participate in diverse chemical reactions and applications.
  • Importance in Research: Scientists are particularly interested in the compound's ammonium functionality, which plays a crucial role in its interaction with biological membranes and cellular systems.

This compound demonstrates the versatility that can arise from modifying simple molecules. As noted by researchers, "The thoughtful design of synthetic compounds like methanesulfonate can unlock new pathways in both chemistry and medicine."

Whether you are exploring its biochemical potentials or investigating its utility in material science, methanesulfonate; [3-methoxy-4-(4-phenylbutoxy)phenyl]ammonium showcases the intricate relationships between chemical structure and function.

Synonyms
15382-74-8
m-ANISIDINE, 4-(4-PHENYLBUTOXY)-, METHANESULFONATE
methanesulfonate;[3-methoxy-4-(4-phenylbutoxy)phenyl]azanium
M & B 4583
4-(4-Phenylbutoxy)-m-anisidine methanesulfonate